Home > Name List By 4 > 4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2, 3-e]thiazine-3-carboxamide

CAS No 59804-37-4 , 4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,
3-e]thiazine-3-carboxamide

  • Name: 4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,
    3-e]thiazine-3-carboxamide
  • Synonyms: Tilcotil; Tenoxicamum; Apo-Tenoxicam; Liman;Mobiflex;4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,
    3-e]thiazine-3-carboxamide; Tenoxicamum [INN-Latin]; Novo-Tenoxicam; 59804-37-4;
  • CAS Registry Number:
  • Transport: UN 2811
  • Density: 1.675 g/cm3
  • Refractive index: 1.741
  • Safety Statements: R23/24/25
  • Hazard Symbols: T: Toxic;
  • Molecular Weight: 337.37414
  • InchiKey: LZNWYQJJBLGYLT-UHFFFAOYSA-N
  • InChI: InChI=1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-
    21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)
  • Risk Statements: S36/37/39;S45
  • Molecular Formula: C13H11N3O4S2
  • Molecular Structure:CAS No:59804-37-4 4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,<br />3-e]thiazine-3-carboxamide

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References of 4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,
3-e]thiazine-3-carboxamide
Title: Tenoxicam
CAS Registry Number: 59804-37-4
CAS Name: 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide
Manufacturers' Codes: Ro-12-0068
Trademarks: Alganex (Roche); Dolmen (Sigma-Tau); Liman (Kali-Chemie); Mobiflex (Roche); Rexalgan (Domp?; Tilatil (Roche); Tilcotil (Roche)
Molecular Formula: C13H11N3O4S2
Molecular Weight: 337.37
Percent Composition: C 46.28%, H 3.29%, N 12.46%, O 18.97%, S 19.01%
Literature References: Nonsteroidal anti-inflammatory agent. Prepn: O. Hromatka et al., DE 2537070 (1976 to Hoffmann-La Roche), C.A. 85, 63077 (1976). Pharmacology: Y. Tanaka et al., Nippon Yakurigaku Zasshi 77, 531 (1981), C.A. 95, 35473 (1981). HPLC determn in plasma: M. E. Pickup et al., J. Chromatogr. 225, 493 (1981). Comparative study vs aspirin in normal volunteers: H. A. Bird et al., Curr. Med. Res. Opin. 8, 9 (1982). Preliminary review of pharmacology, therapeutic efficacy and mechanism of action: J. P. Gonzalez, P. A. Todd, Drugs 34, 289-310 (1987). Comprehensive description: A. M. Al-Obaid, M. S. Mian, Anal. Profiles Drug Subs. Excip. 22, 431-459 (1993).
Properties: Crystals from xylene, mp 209-213° (dec). Soly (mg/ml): water 0.045; ethanol <1; methanol <1; acetone 2; dichloromethane 10; chloroform 8; DMSO 63. uv max (ethanol): 205, 265, 360 nm (e 16422.12, 10127.42, 12544.21). pKa1 5.3, pKa2 1.1. Partition coefficient (octanol/water): 0.3 (pH 7.4); 3.5 (pH 1.2).
Melting point: mp 209-213° (dec)
pKa: pKa1 5.3, pKa2 1.1
Log P: Partition coefficient (octanol/water): 0.3 (pH 7.4); 3.5 (pH 1.2)
Absorption maximum: uv max (ethanol): 205, 265, 360 nm (e 16422.12, 10127.42, 12544.21)
Therap-Cat: Anti-inflammatory; analgesic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Thiazinecarboxamides.