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CAS No 59729-31-6 , N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide

  • Name: N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide
  • Synonyms: Lorcainida [INN-Spanish]; BRN 0497568; 59729-31-6;N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide; Lorcainidum [INN-Latin];Lorcainide [INN:BAN];
  • CAS Registry Number:
  • Flash Point: 258°C
  • Boiling Point: 503°C at 760 mmHg
  • Density: 1.161g/cm3
  • Refractive index: 1.594
  • Flash Point: 258°C
  • Molecular Weight: 370.91558
  • InchiKey: XHOJAWVAWFHGHL-UHFFFAOYSA-N
  • InChI: InChI=1S/C22H27ClN2O/c1-17(2)24-14-12-21(13-15-24)25(20-10-8-19(23)9-11-
    20)22(26)16-18-6-4-3-5-7-18/h3-11,17,21H,12-16H2,1-2H3
  • Molecular Formula: C22H27ClN2O
  • Molecular Structure:CAS No:59729-31-6 N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide

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References of N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide
Title: Lorcainide
CAS Registry Number: 59729-31-6
CAS Name: N-(4-Chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]benzeneacetamide
Synonyms: 4￠-chloro-N-(1-isopropyl-4-piperidyl)-2-phenylacetanilide
Molecular Formula: C22H27ClN2O
Molecular Weight: 370.92
Percent Composition: C 71.24%, H 7.34%, Cl 9.56%, N 7.55%, O 4.31%
Literature References: Prepn: S. Sanczuk, H. K. F. Hermans, DE 2642856 (1977 to Janssen), C.A. 87, 53094 (1977); eidem, US 4126689 (1978 to Janssen). Determn of lorcainide and its metabolites by GLC: R. Woestenborghs et al., J. Chromatogr. 164, 169 (1979). Disposition and anti-arrhythmic effects: U. Klotz et al., Int. J. Clin. Pharmacol. Biopharm. 17, 152 (1979). Pharmacokinetics and tissue distribution: U. Klotz, E. Golbs, Arzneim.-Forsch. 30, 619 (1980). Clinical study: P. Somani, S. di Giorgi, Chest 78, 658 (1980). Toxicology: G. J. Barton, R. Marsboom, "A Brief Summary of Animal Toxicology Studies on Lorcainide", in Prognosis and Pharmacotherapy of Life-Threatening Arrhythmias, J?hnchen et al., Eds. (Royal Soc. Med. London, 1981) pp 23-25. Review of pharmacology and efficacy: C. E. Eriksson, R. N. Brogden, Drugs 27, 279-300 (1984). Symposium: Am. J. Cardiol. 54, 1B-54B (1984).
Properties: LD50 in male mice, male and female rats (mg/kg): 18.8, 19.3, 18.6 i.v.; 483, 395, 435 orally (Barton, Marsboom).
Toxicity data: LD50 in male mice, male and female rats (mg/kg): 18.8, 19.3, 18.6 i.v.; 483, 395, 435 orally (Barton, Marsboom)
 
Derivative Type: Hydrochloride
CAS Registry Number: 58934-46-6
Manufacturers' Codes: R-15889; Ro-13-1042
Trademarks: Lopantrol (Janssen); Lorivox (Srbolek); Remivox (Janssen)
Molecular Formula: C22H27ClN2O.HCl
Molecular Weight: 407.38
Percent Composition: C 64.86%, H 6.93%, Cl 17.41%, N 6.88%, O 3.93%
Properties: Crystals from 2-propanone and 2-propanol, mp 263°.
Melting point: mp 263°
 
Therap-Cat: Antiarrhythmic (class IC).
Keywords: Antiarrhythmic.