References of 1-[2-(3,4-dimethoxyphenyl)ethylamino]-3-(3-methylphenoxy)propan-2-ol
Title: Bevantolol
CAS Registry Number: 59170-23-9
CAS Name: 1-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol
Synonyms: 1-[(3,4-dimethoxyphenethyl)amino]-3-(
m-tolyloxy)-2-propanol
Molecular Formula: C20H27NO4
Molecular Weight: 345.43
Percent Composition: C 69.54%, H 7.88%, N 4.05%, O 18.53%
Literature References: Cardioselective b1-adrenergic blocker. Prepn:
BE 790165; A. Holmes, R. F. Meyer,
US 3857891 (1973, 1974 both to Parke, Davis & Co.); M. L. Hoefle
et al., J. Med. Chem. 18, 148 (1975). Pharmacology in animals: S. G. Hastings
et al., Arch. Int. Pharmacodyn. Ther. 226, 81 (1977). Cardiovascular effects in animals: I. D. Dukes, E. M. Vaughan Williams,
Br. J. Pharmacol. 84, 365 (1985). Cardioselectivity in asthmatic patients: C.-G. L?fdahl
et al., Pharmacotherapy 4, 205 (1984). GC determn in plasma: E. J. Randinitis
et al., J. Chromatogr. 308, 345 (1984). Pharmacokinetics in humans: P. Vermeij, P. van Brummelen,
Eur. J. Clin. Pharmacol. 30, 375 (1986). Comparative clinical trial with hydrochlorothiazide in hypertension: C. P. Lucas
et al., Clin. Ther. 8, 49 (1985). Symposium on pharmacology and clinical efficacy:
Am. J. Cardiol. 58, 1E-44E (1986).
Derivative Type: Hydrochloride
CAS Registry Number: 42864-78-8
Manufacturers' Codes: CI-775
Trademarks: Ranestol (Parke-Davis); Sentiloc (Benzon); Vantol (Parke-Davis)
Molecular Formula: C20H27NO4.HCl
Molecular Weight: 381.89
Percent Composition: C 62.90%, H 7.39%, N 3.67%, O 16.76%, Cl 9.28%
Properties: Crystals from acetonitrile, mp 137-138°.
Melting point: mp 137-138°
Therap-Cat: Antianginal; antihypertensive; antiarrhythmic.
Keywords: ?Adrenergic Blocker; Antianginal; Antiarrhythmic; Antihypertensive; Aryloxypropanolamine Derivatives.