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CAS No 59-92-7 , (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid Search by region : China

  • Name: (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
  • Synonyms: (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid; Larodopa; Maipedopa; Bendopa;L-dopa; Levopa; Dopar; Dopaidan; Insulamina; Cidandopa;
  • CAS Registry Number:
  • Transport: OTH
  • Melting Point: 295 ºC
  • Density: 1.468g/cm3
  • Refractive index: -12 ° (C=5, 1mol/L HCl)
  • Alpha: -11.7 º (C=5.3, 1N HCL)
  • Safety Statements: R22
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 200-445-2
  • Molecular Weight: 197.18794
  • InchiKey: WTDRDQBEARUVNC-LURJTMIESA-N
  • InChI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,
    10H2,(H,13,14)/t6-/m0/s1
  • Risk Statements: S24/25
  • Molecular Formula: C9H11NO4
  • Molecular Structure:CAS No:59-92-7 (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid

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59-92-7 Levodopa

  • Alias: ;HYDROXYTYROSINEL-DOPA, L-3-HYDROXYTYROSINE Product Details: Place of Origin: China Certification: ISO9001 Brand:YuanCheng Payment & Shipping Terms: Minimum Order Quantity:1kg Supply Ability:500kg/month Delivery Time:within 24 hours after paym...
  • China Zhuzhou Yuancheng Hezhong Technology Development Co., Ltd. [Manufacturer, Trading Company]
  • Tel: 86-731-22292056
  • Address: No. 388, Huangshan Rd, Tianyuan District, Zhuzhou City, Hunan Province, P.R.China. zhuzhou,HunanChina
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59-92-7 Levodopa

  • Alias: ;HYDROXYTYROSINEL-DOPA, L-3-HYDROXYTYROSINE Product Details: Place of Origin: China Certification: ISO9001 Brand:YuanCheng Payment & Shipping Terms: Minimum Order Quantity:1kg Supply Ability:500kg/month Delivery Time:within 24 hours after paym...
  • China Zhuzhou Yuancheng Hezhong Technology Development Co., Ltd. [Manufacturer, Trading Company]
  • Tel: 86-027-50756185
  • Fax: --
  • Address: No. 388, Huangshan Rd, Tianyuan District, Zhuzhou City, Hunan Province, P.R.China. Zhuzhou,HunanChina
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  • 59-92-7 L-DOPA

    • L-DOPA Synonym: L-3-(3,4-Dihydroxyphenyl)alanine; Levodopa; L-DOPA 3,4-L-Dihydroxyphenylalanine; 3-Hydroxy-L-tyrosine; H-Tyr(3-OH)-OH; L-3-Hydroxytyrosine CAS: 59-92-7 EINECS: 200-445-2 Assay: 20% M.F: C9H11NO4 M.W: 197.1879 M.S: Specific Rotate: MP ...
    • Min. Order: 500
    • China Wuhan Yuancheng Group [Manufacturer, Trading Company]
    • Tel: 86-027-50756153
    • Address: Zhongshan Road Wuhan,HubeiChina
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    59-92-7 Levodopa

    • Levodopa Alias: ;HYDROXYTYROSINEL-DOPA, L-3-HYDROXYTYROSINE Product Details: Place of Origin: China Certification: ISO9001 Brand:YuanCheng Payment & Shipping Terms: Minimum Order Quantity:1kg Supply Ability:500kg/month Delivery Time:within 24 hours a...
    • Min. Order: 1400
    • China Zhuzhou Yuancheng Hezhong Technology Development Co., Ltd. [Manufacturer]
    • Tel: 86-731-22290217
    • Fax: --
    • Address: No. 388, Huangshan Rd zhuzhou,HunanChina
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    59-92-7 Levodopa

    • Levodopa Alias: ;HYDROXYTYROSINEL-DOPA, L-3-HYDROXYTYROSINE Product Details: Place of Origin: China Certification: ISO9001 Brand:YuanCheng Payment & Shipping Terms: Minimum Order Quantity:1kg Supply Ability:500kg/month Delivery Time:within 24 hours a...
    • Min. Order: 25
    • FOB Price: USD1 - 1 /
    • China Zhuzhou Yuancheng Hezhong Technology Development Co., Ltd. [Manufacturer]
    • Tel: 86-181-88938010
    • Address: No. 388, Huangshan Rd, Tianyuan District, Zhuzhou City, Hunan Province, P.R.China. Zhuzhou,HunanChina
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    59-92-7 59-92-7

    • Levodopa Alias: ;HYDROXYTYROSINEL-DOPA, L-3-HYDROXYTYROSINE Product Details: Place of Origin: China Certification: ISO9001 Brand:YuanCheng Payment & Shipping Terms: Minimum Order Quantity:1kg Supply Ability:500kg/month Delivery Time:within 24 hours a...
    • Min. Order: 25
    • FOB Price: USD1 - 1 /
    • China Zhuzhou Yuancheng Hezhong Technology Development C [Manufacturer]
    • Tel: 86-027-50756060
    • Address: No. 388, Huangshan Rd, Tianyuan District, Zhuzhou City, Hunan Province, P.R.China. Zhuzhou,HunanChina
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    59-92-7 Levodopa

    • Levodopa Levodopa (L-Dopa, L-Tyrosine, Larodopa, Dopar) CAS no.: 59-92-7 Molecular formula: C9H11NO4 Molecular weight: 197.19 Plant source: Seed of M.cochin chinensis(Lonr.). Action: a. improve the level of dopa aminein cerebral tissues. b. effect on...
    • China Wuhan Changland Technology Co.Ltd [Manufacturer]
    • Tel: 86-27-87290719
    • Fax: 86-27-68786490
    • Address: Changland Technology Co.,LTD Wuhan,HubeiChina
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    59-92-7 L-DOPA

    • China Taiyuan RHF CO., ltd. [Manufacturers]
    • Tel: 0351-7436719
    • Fax: +86-351-7436719
    • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi null,ShanXiChina
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    59-92-7 L-DOPA

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    59-92-7 L-Dopa

    • L-DopaL-Dopa, 98%
    • China PMIDA AGROCHEMICAL CO.,LTD [Manufacturer]
    • Tel: +86-023-67030808-8010
    • Fax: +86-023-67030809
    • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone401121 ChongqingCHINA Chongqing,nullChina
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    References of (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
    Title: Levodopa
    CAS Registry Number: 59-92-7
    CAS Name: 3-Hydroxy-L-tyrosine
    Synonyms: (-)-3-(3,4-dihydroxyphenyl)-L-alanine; L-dopa; b-(3,4-dihydroxyphenyl)-L-alanine; (-)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
    Trademarks: Bendopa (ICN); Deadopa (DeAngeli); Dopaflex (Medimpex); Dopal (Kyowa); Dopaidan (DeAngeli); Dopalina (Lepetit); Dopar; Doparkine (Armstrong); Doparl (Kyowa); Dopasol (Daiichi); Dopaston (Sankyo); Dopastral (Astra); Cidandopa (Cid¤); Doprin (SK & F); Eldopal (Yamanouchi); Eldopar (Weifa); Eldopatec (Labatec); Eurodopa (Europharma); Laradopa (Roche); Maipedopa (Maipe); Larodopa (Roche); Ledopa (Lepetit); Parda (Parke-Davis); Levopa (ICN); Veldopa (formerly Weldopa) (Smith & Nephew)
    Molecular Formula: C9H11NO4
    Molecular Weight: 197.19
    Percent Composition: C 54.82%, H 5.62%, N 7.10%, O 32.45%
    Literature References: Naturally occurring form of dopa, q.v., the biological precursor of the catecholamines. Prepn from l-3-nitrotyrosin: Wasser, Lewandowski, Helv. Chim. Acta 4, 657 (1921); from 3-(3,4-methylenedioxyphenyl)-L-alanine: Yamada et al., Chem. Pharm. Bull. 10, 693 (1962); from L-tyrosine: Vorbrüggen, Krolikiewicz, Ber. 105, 1168 (1972); Bretschneider et al., Helv. Chim. Acta 56, 2857 (1973); from Vicia faba beans: Wysong, US 3253023 (1966 to Dow Chem.); by fermentation of L-tyrosine: Sih et al., J. Am. Chem. Soc. 91, 6204 (1969); Florent, Renaut, DE 2102793 (1971 to Rh?ne-Poulenc), C.A. 75, 108505f (1971). Sepn from racemate: Vogler, Baumgartner, Helv. Chim. Acta 35, 1776 (1952); NL 6514950; US 3405159 (1966, 1968 both to Merck & Co.). Molecular conformation: Becker et al., Biochem. Biophys. Res. Commun. 41, 444 (1970). Metabolism studies: Shaw et al., J. Biol. Chem. 226, 255 (1957); Calne et al., Br. J. Pharmacol. 37, 57 (1969). Hemodynamic effects in congestive heart failure: S. I. Rajfer et al., N. Engl. J. Med. 310, 1357 (1984). Series of articles on clinical efficacy in Parkinson's disease: Adv. Neurol. 45, 457-510 (1986). Reviews on L-dopa and parkinsonism: Barbeau, Can. Med. Assoc. J. 101, 791 (1969); Pletscher et al., Schweiz. Med. Wochenschr. 100, 797 (1970); Calne, Sandler, Nature 226, 21 (1970); L-Dopa and Parkinsonism, A. Barbeau, Ed. (F. A. Davis, Philadelphia, 1970). Review of acute toxicity data: W. G. Clark et al., Toxicol. Appl. Pharmacol. 28, 1-7 (1974). Comprehensive description: R. Gomez et al., Anal. Profiles Drug Subs. 5, 189-223 (1976).
    Properties: Colorless to white, odorless and tasteless crystals or crystalline powder. Needles from water, mp 276-278° (dec) (Yamada); also reported as mp 284-286° (Wysong). [a]D13 -13.1° (c = 5.12 in 1N HCl). uv max (0.001N HCl): 220.5, 280 nm (log e 3.79, 3.42). Readily sol in dil HCl and formic acid. Soly in water: 66 mg/40 ml. Practically insol in ethanol, benzene, chloroform and ethyl acetate. In the presence of moisture, L-dopa is rapidly oxidized by atmospheric oxygen and darkens. LD50 in mice (mg/kg): 3650 ±327 orally, 1140 ±66 i.p., 450 ±42 i.v., >400 s.c.; in male, female rats (mg/kg): >3000, >3000 orally; 624, 663 i.p.; >1500, >1500 s.c. (Clark).
    Melting point: mp 276-278° (dec) (Yamada); mp 284-286° (Wysong)
    Optical Rotation: [a]D13 -13.1° (c = 5.12 in 1N HCl)
    Absorption maximum: uv max (0.001N HCl): 220.5, 280 nm (log e 3.79, 3.42)
    Toxicity data: LD50 in mice (mg/kg): 3650 ±327 orally, 1140 ±66 i.p., 450 ±42 i.v., >400 s.c.; in male, female rats (mg/kg): >3000, >3000 orally; 624, 663 i.p.; >1500, >1500 s.c. (Clark)
    Therap-Cat: Antiparkinsonian.
    Keywords: Antiparkinsonian.