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CAS No 59-92-7 , (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid

  • Name: (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
  • Synonyms: (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid; Larodopa; Maipedopa; Bendopa;L-dopa; Levopa; Dopar; Dopaidan; Insulamina; Cidandopa;
  • CAS Registry Number:
  • Transport: OTH
  • Melting Point: 295 ºC
  • Density: 1.468g/cm3
  • Refractive index: -12 ° (C=5, 1mol/L HCl)
  • Alpha: -11.7 º (C=5.3, 1N HCL)
  • Safety Statements: R22
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 200-445-2
  • Molecular Weight: 197.18794
  • InchiKey: WTDRDQBEARUVNC-LURJTMIESA-N
  • InChI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,
    10H2,(H,13,14)/t6-/m0/s1
  • Risk Statements: S24/25
  • Molecular Formula: C9H11NO4
  • Molecular Structure:CAS No:59-92-7 (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid

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References of (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
Title: Levodopa
CAS Registry Number: 59-92-7
CAS Name: 3-Hydroxy-L-tyrosine
Synonyms: (-)-3-(3,4-dihydroxyphenyl)-L-alanine; L-dopa; b-(3,4-dihydroxyphenyl)-L-alanine; (-)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
Trademarks: Bendopa (ICN); Deadopa (DeAngeli); Dopaflex (Medimpex); Dopal (Kyowa); Dopaidan (DeAngeli); Dopalina (Lepetit); Dopar; Doparkine (Armstrong); Doparl (Kyowa); Dopasol (Daiichi); Dopaston (Sankyo); Dopastral (Astra); Cidandopa (Cid¤); Doprin (SK & F); Eldopal (Yamanouchi); Eldopar (Weifa); Eldopatec (Labatec); Eurodopa (Europharma); Laradopa (Roche); Maipedopa (Maipe); Larodopa (Roche); Ledopa (Lepetit); Parda (Parke-Davis); Levopa (ICN); Veldopa (formerly Weldopa) (Smith & Nephew)
Molecular Formula: C9H11NO4
Molecular Weight: 197.19
Percent Composition: C 54.82%, H 5.62%, N 7.10%, O 32.45%
Literature References: Naturally occurring form of dopa, q.v., the biological precursor of the catecholamines. Prepn from l-3-nitrotyrosin: Wasser, Lewandowski, Helv. Chim. Acta 4, 657 (1921); from 3-(3,4-methylenedioxyphenyl)-L-alanine: Yamada et al., Chem. Pharm. Bull. 10, 693 (1962); from L-tyrosine: Vorbrüggen, Krolikiewicz, Ber. 105, 1168 (1972); Bretschneider et al., Helv. Chim. Acta 56, 2857 (1973); from Vicia faba beans: Wysong, US 3253023 (1966 to Dow Chem.); by fermentation of L-tyrosine: Sih et al., J. Am. Chem. Soc. 91, 6204 (1969); Florent, Renaut, DE 2102793 (1971 to Rh?ne-Poulenc), C.A. 75, 108505f (1971). Sepn from racemate: Vogler, Baumgartner, Helv. Chim. Acta 35, 1776 (1952); NL 6514950; US 3405159 (1966, 1968 both to Merck & Co.). Molecular conformation: Becker et al., Biochem. Biophys. Res. Commun. 41, 444 (1970). Metabolism studies: Shaw et al., J. Biol. Chem. 226, 255 (1957); Calne et al., Br. J. Pharmacol. 37, 57 (1969). Hemodynamic effects in congestive heart failure: S. I. Rajfer et al., N. Engl. J. Med. 310, 1357 (1984). Series of articles on clinical efficacy in Parkinson's disease: Adv. Neurol. 45, 457-510 (1986). Reviews on L-dopa and parkinsonism: Barbeau, Can. Med. Assoc. J. 101, 791 (1969); Pletscher et al., Schweiz. Med. Wochenschr. 100, 797 (1970); Calne, Sandler, Nature 226, 21 (1970); L-Dopa and Parkinsonism, A. Barbeau, Ed. (F. A. Davis, Philadelphia, 1970). Review of acute toxicity data: W. G. Clark et al., Toxicol. Appl. Pharmacol. 28, 1-7 (1974). Comprehensive description: R. Gomez et al., Anal. Profiles Drug Subs. 5, 189-223 (1976).
Properties: Colorless to white, odorless and tasteless crystals or crystalline powder. Needles from water, mp 276-278° (dec) (Yamada); also reported as mp 284-286° (Wysong). [a]D13 -13.1° (c = 5.12 in 1N HCl). uv max (0.001N HCl): 220.5, 280 nm (log e 3.79, 3.42). Readily sol in dil HCl and formic acid. Soly in water: 66 mg/40 ml. Practically insol in ethanol, benzene, chloroform and ethyl acetate. In the presence of moisture, L-dopa is rapidly oxidized by atmospheric oxygen and darkens. LD50 in mice (mg/kg): 3650 ±327 orally, 1140 ±66 i.p., 450 ±42 i.v., >400 s.c.; in male, female rats (mg/kg): >3000, >3000 orally; 624, 663 i.p.; >1500, >1500 s.c. (Clark).
Melting point: mp 276-278° (dec) (Yamada); mp 284-286° (Wysong)
Optical Rotation: [a]D13 -13.1° (c = 5.12 in 1N HCl)
Absorption maximum: uv max (0.001N HCl): 220.5, 280 nm (log e 3.79, 3.42)
Toxicity data: LD50 in mice (mg/kg): 3650 ±327 orally, 1140 ±66 i.p., 450 ±42 i.v., >400 s.c.; in male, female rats (mg/kg): >3000, >3000 orally; 624, 663 i.p.; >1500, >1500 s.c. (Clark)
Therap-Cat: Antiparkinsonian.
Keywords: Antiparkinsonian.