Title: Ethopabate
CAS Registry Number: 59-06-3
CAS Name: 4-Acetamido-2-ethoxybenzoic acid methyl ester
Synonyms: methyl 4-acetamido-2-ethoxybenzoate; 2-ethoxy-4-acetamidobenzoic acid methyl ester; ethyl pabate
Molecular Formula: C12H15NO4
Molecular Weight: 237.25
Percent Composition: C 60.75%, H 6.37%, N 5.90%, O 26.97%
Literature References: Prepn: Grimme, Schmitz,
Ber. 87, 179 (1954); E. F. Rogers, R. L. Clark,
BE 613166;
eidem, US 3211610 (1962, 1965 both to Merck & Co.);
FR 1407055; M. L. Thominet,
US 3357978 (1965, 1967 both to Soc. d'Etudes Sci. Ind. de l'Ile-de-France). Anticoccidial activity studies: Rogers
et al., Proc. Soc. Exp. Biol. Med. 117, 488 (1964). Metabolism in chickens: Buhs
et al., J. Pharmacol. Exp. Ther. 154, 357 (1966).
Properties: White to pinkish-white, practically odorless crystals from methanol and water, mp 148-149°. uv max (methanol): 298, 267 nm (A1%1cm 805, 365). Sol in methanol, ethanol, acetone, acetonitrile. Sparingly sol in isopropanol,
p-dioxane, ethyl acetate, methylene chloride; very slightly sol in water and isooctane.
Melting point: mp 148-149°
Absorption maximum: uv max (methanol): 298, 267 nm (A1%1cm 805, 365)
Derivative Type: Mixture with amprolium
Trademarks: Amprol Plus (Merck & Co.)
Therap-Cat-Vet: Mixture as coccidiostat.
