CAS No 58409-59-9 , 2H-1-Benzopyran-2-one,8-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-5-methyl-

Name: 2H-1-Benzopyran-2-one,8-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-5-methyl-
Synonyms: 2H-1-Benzopyran-2-one,8-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-5-methyl-;dl-Bucumolol;Bucumolol;
CAS Registry Number:58409-59-9
Flash Point: 250.6°C
Boiling Point: 490.7°Cat760mmHg
Density: 1.16g/cm³
Refractive index: 1.552
Flash Point: 250.6°C
Molecular Weight: 0
InChI: InChI=1/C17H23NO4/c1-11-5-7-14(16-13(11)6-8-15(20)22-16)21-10-12(19)9-18-17(2,3)4/h5-8,12,18-19H,9-10H2,1-4H3
Molecular Formula: C17H23 N O4
Molecular Structure:

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           58409-59-9 BUCUMOLOL HYDROCHLORIDE
           
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References of 2H-1-Benzopyran-2-one,8-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-5-methyl-

Title: Bucumolol
CAS Registry Number: 58409-59-9
CAS Name: 8-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-5-methyl-2H-1-benzopyran-2-one
Synonyms: (±)-8-[3-(t-butylamino)-2-hydroxypropoxy]-5-methylcoumarin; dl-8-(2-hydroxy-3-tert-butylaminopropoxy)coumarin
Molecular Formula: C17H23NO4
Molecular Weight: 305.37
Percent Composition: C 66.86%, H 7.59%, N 4.59%, O 20.96%
Literature References: b-Adrenergic blocker. Prepn: Y. Sato et al., DE 2021958; eidem, US 3663570 (1970, 1972 both to Sankyo); eidem, Chem. Pharm. Bull. 20, 905 (1972). Pharmacology: T. Oshima et al., Jpn. J. Pharmacol. 23, 497 (1973). Metabolic studies: R. Hayashi et al., Chem. Pharm. Bull. 23, 1173 (1975). Antiarrhythmic activity in dogs: K. Nakayama et al., Jpn. J. Pharmacol. 29, 935 (1979). Early clinical study: H. Kishida et al., Rinsho Yakuri 11, 99 (1980), C.A. 93, 107380w (1980).

Derivative Type: Hydrochloride
CAS Registry Number: 36556-75-9
Manufacturers' Codes: CS-359
Trademarks: Bucumarol (Sankyo)
Molecular Formula: C17H23NO4.HCl
Molecular Weight: 341.83
Percent Composition: C 59.73%, H 7.08%, N 4.10%, O 18.72%, Cl 10.37%
Properties: Colorless crystals from isopropanol, mp 226-228° (dec). LD50 in male, female mice (mg/kg): 676, 692 orally; 33.1, 31.6 i.v. (Oshima).
Melting point: mp 226-228° (dec)
Toxicity data: LD50 in male, female mice (mg/kg): 676, 692 orally; 33.1, 31.6 i.v. (Oshima)

Therap-Cat: Antianginal, antiarrhythmic.
Keywords: ?Adrenergic Blocker; Antianginal; Antiarrhythmic.