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CAS No 51781-06-7 , 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one

  • Name: 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one
  • Synonyms: 51781-06-7;5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one;Carteololum; Carteolol [INN:BAN]; Carteolol HCl; CHEBI:3437; Carteolol Monohydrochloride; Carteololum [INN-Latin];
  • CAS Registry Number:
  • Density: 1.13 g/cm3
  • Safety Statements: Poison by intravenous route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.
  • Molecular Weight: 292.37336
  • InchiKey: LWAFSWPYPHEXKX-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H24N2O3/c1-16(2,
    3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13/h4-6,11,17,19H,
    7-10H2,1-3H3,(H,18,20)
  • Molecular Formula: C16H24N2O3
  • Molecular Structure:CAS No:51781-06-7 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one
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51781-06-7 Carteolol

  • Carteolol
  • China Shanghai Synnad Chemical Co., Ltd. [Importer/Exporter]
  • Tel: 86 21 5109 7911
  • Fax: 86 21 5109 7955
  • Address: B-5 Ecust Science Park, No. 18, Lane 1305, Hua Jing Road, Shanghai 200231 China Shanghai,ShanghaiChina
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51781-06-7 Carteolol

  • Carteolol, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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51781-06-7 Carteolol

  • Carteolol, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,China
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51781-06-7 Carteolol

  • Carteolol
  • Switzerland BIOTREND Chemicals AG [Manufacturer]
  • Tel: +41 44 805 76 76
  • Fax: +41 44 805 76 77
  • Address: BIOTREND Chemicals AG
    Unterdorfstr. 21b
    CH-8602 Wangen/Zuerich
    Switzerland ,Switzerland
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51781-06-7 Carteolol

  • United States CBSCHEM LIMITED []
  • Fax: (888) 557-9843
  • Address: 621 South 48th Street, Suite 115,Tempe, AZ 85281 ,United States
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51781-06-7 Carteolol

  • China suchem pharma co.,limited [Manufacturers]
  • Tel: 86-57781172668
  • Fax: 8657785505511
  • Address: wenzhou, China Wenzhou,ZhejiangChina
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51781-06-7 Carteolol

  • Carteolol
  • United States AvaChem Scientific LLC [Manufacturer]
  • Tel: 210-667-3815
  • Fax: 210-764-2240
  • Address: P.O.Box 78044278278 San Antonio, TexasUNITED STATES 78278 San Antonio, Texas,United States
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51781-06-7 Carteolol

  • Hong kong Leawell International Limited [Importer/Exporter]
  • Tel: +852-(2576)-0298
  • Fax: +852-(2895)-4635
  • Address: 18/F Catic Plaza, 8 Causeway Road Causeway Bay, Guangzhou,GuangdongHong kong
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51781-06-7 Carteolol HCl

  • Carteolol HCl
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany ,Germany
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51781-06-7 CARTEOLOL

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China ,China
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References of 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one
Title: Carteolol
CAS Registry Number: 51781-06-7
CAS Name: 5-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-2(1H)-quinolinone
Synonyms: 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydrocarbostyril
Molecular Formula: C16H24N2O3
Molecular Weight: 292.37
Percent Composition: C 65.73%, H 8.27%, N 9.58%, O 16.42%
Literature References: b-Adrenergic blocker. Prepn: K. Nakagawa et al., DE 2302027; Y. Tamura et al., US 3910924 (1973, 1975 both to Otsuka); K. Nakagawa, J. Med. Chem. 17, 529 (1974). Pharmacological evaluation in rats: S. Morita et al., Biochem. Pharmacol. 25, 1836 (1976). HPLC determn in plasma and urine: S. Y. Chu, J. Pharm. Sci. 67, 1623 (1978). In vitro study: S. Chiba, Arzneim.-Forsch. 29, 895 (1979). Carcinogenicity study: M. Kurosomi et al., Farmaco Ed. Prat. 34, 202 (1979). Series of articles on pharmacology, toxicology and clinical studies: Arzneim.-Forsch. 33, 277-345 (1983). Acute toxicity data: W. Lang, ibid. 290. Review of clinical experience in glaucoma and ocular hypertension: P. Chrisp, E. M. Sorkin, Drugs Aging 2, 58-77 (1992).
 
Derivative Type: Hydrochloride
CAS Registry Number: 51781-21-6
Manufacturers' Codes: Abbott 43326; OPC-1085
Trademarks: Arteoptic (Novartis); Carteol (Otsuka); Endak (Madaus); Mikelan (Otsuka); Ocupress (Novartis); Teoptic (Novartis)
Molecular Formula: C16H24N2O3.HCl
Molecular Weight: 328.83
Percent Composition: C 58.44%, H 7.66%, N 8.52%, O 14.60%, Cl 10.78%
Properties: Crystals from ethanol, mp 278°. LD50 in male mice, rats (mg/kg): 810, 1380 orally; 54.5, 158 i.v.; 380, 400 i.p. (Lang).
Melting point: mp 278°
Toxicity data: LD50 in male mice, rats (mg/kg): 810, 1380 orally; 54.5, 158 i.v.; 380, 400 i.p. (Lang)
 
Therap-Cat: Antihypertensive; antianginal; antiarrhythmic; antiglaucoma.
Keywords: ?Adrenergic Blocker; Antianginal; Antiarrhythmic; Antiglaucoma; Antihypertensive; Aryloxypropanolamine Derivatives.