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CAS No 58152-03-7 , Isepamicine

  • Name: Isepamicine
  • Synonyms: Isepamicine;(2S)-3-Amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-2-[(3R,4R,5R)-3,5-dihydroxy-5-methyl-4-methylaminooxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxypropanamide;
  • CAS Registry Number:
  • Flash Point: 514.3°C
  • Boiling Point: 926.8°Cat760mmHg
  • Density: 1.53g/cm3
  • Refractive index: 1.641
  • Safety Statements: Poison by intravenous route. Mildly toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 514.3°C
  • EINECS: 261-143-4
  • Molecular Weight: 569.61
  • InChI: InChI=1/C22H43N5O12/c1-22(35)6-36-20(15(33)18(22)26-2)39-17-8(27-19(34)9(28)4-23)3-7(25)16(14(17)32)38-21-13(31)12(30)11(29)10(5-24)37-21/h7-18,20-21,26,28-33,35H,3-6,23-25H2,1-2H3,(H,27,34)
  • Molecular Formula: C22H43N5O12
  • Molecular Structure:CAS No:58152-03-7 Isepamicine

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58152-03-7 Isepamicin

  • United States Tecoland Corporation null
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58152-03-7 Isepamicin

  • China Hwasun Biotechnology Co., Ltd. null
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  • Address: Rm.505, Bldg. 2,No. 245 Jiachuan RD. Xuhui Dist.,200237, Shanghai, China null,nullChina
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58152-03-7 Isepamicin

  • China Hwasun Biotechnology Co., Ltd [Manufacturers]
  • Tel: +86-21-64764896 64764113
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  • Address: Rm.411,415 Bldg. 2 No.2715 Longwu Rd., Xuhui Dist, Shanghai China 200231 null,ShanghaiChina
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58152-03-7 ISEPAMICIN SULFATE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
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References of Isepamicine
Title: Isepamicin
CAS Registry Number: 58152-03-7
CAS Name: O-6-Amino-6-deoxy-a-D-glucopyranosyl-(1?4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(1?6)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-D-streptamine
Synonyms: 1-N-[(S)-3-amino-2-hydroxypropionyl]gentamicin B; HAPA-B
Manufacturers' Codes: Sch-21420
Molecular Formula: C22H43N5O12
Molecular Weight: 569.60
Percent Composition: C 46.39%, H 7.61%, N 12.30%, O 33.71%
Literature References: Aminoglycoside antibiotic; semisynthetic derivative of gentamicin B. Prepn: M. J. Weinstein et al., BE 818431; J. J. Wright, P. J. L. Daniels, BE 824657 (both 1975 to Sherico); J. J. Wright et al., US 4002742 (1977 to Schering Corp.); T. L. Nagabhushan et al., J. Antibiot. 31, 681 (1978). Antibacterial spectrum in vitro and in vivo: G. H. Miller et al., ibid. 688. Comparison with amikacin of nephrotoxic potential: L. I. Rankin et al., Antimicrob. Agents Chemother. 16, 491 (1979). Series of articles on antibacterial activity, toxicology and clinical efficacy: Chemotherapy (Tokyo) 35, Suppl 5, 1-610 (1985); on toxicology: Jpn. J. Antibiot. 39, 3164-3328 (1986), C.A. 107, 32666r-32673r (1987). Acute toxicity: T. Morino et al., ibid. 3164, C.A. 107, 32667s (1987).
 
Derivative Type: Sulfate
CAS Registry Number: 67814-76-0
Trademarks: Exacin (Schering); Isepacin (Toyo Jozo); Isépalline (Schering)
Properties: [a]D26 +110.9° (c = 1 in water as the disulfate hydrate). LD50 in male, female mice, rats (mg/kg): 234, 236, 489, 476 i.v.; 3312, 3320, 3451, 3392 s.c.; >5000 orally both species (Morino).
Optical Rotation: [a]D26 +110.9° (c = 1 in water as the disulfate hydrate)
Toxicity data: LD50 in male, female mice, rats (mg/kg): 234, 236, 489, 476 i.v.; 3312, 3320, 3451, 3392 s.c.; >5000 orally both species (Morino)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Aminoglycosides.