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CAS No 58066-85-6 , hexadecyl 2-(trimethylazaniumyl)ethyl phosphate

  • Name: hexadecyl 2-(trimethylazaniumyl)ethyl phosphate
  • Synonyms: Miltefosinum; Impavido; HePC; Miltefosina; 58066-85-6; Hexadecylphosphorylcholine; HDPC;Hexadecylphosphocholine; Miltex;hexadecyl 2-(trimethylazaniumyl)ethyl phosphate;
  • CAS Registry Number:
  • Melting Point: 232-234ºC
  • Water Solubility: Insoluble in water.Soluble in methanol.
  • Safety Statements: A poison by ingestion. When heated to decomposition it emits toxic vapors of NOx and POx.
  • Molecular Weight: 407.568002
  • InchiKey: PQLXHQMOHUQAKB-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,
    24)26-21-19-22(2,3)4/h5-21H2,1-4H3
  • Molecular Formula: C21H46NO4P
  • Molecular Structure:CAS No:58066-85-6 hexadecyl 2-(trimethylazaniumyl)ethyl phosphate
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58066-85-6 hexadecylphosphocholine

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58066-85-6 N-Hexadecyl-phosphocholine

  • N-Hexadecyl-phosphocholine
  • United States INDOFINE Chemical Co., Inc. [Manufacturer]
  • Tel: (908) 359-6778
  • Fax: (908) 359-1179
  • Address: 121 Stryker Lane
    Bldg 30, Suite 1
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58066-85-6 Miltefosine

  • Miltefosine
  • China Sunkingchem Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-28-88007744
  • Fax: +86-28-85193812
  • Address: A-703, Gaofa Building, Jiuxing Road 6#, Hi-Tech Zone 610041, Chengdu, Sichuan, China.610041 ChengduCHINA Chengdu,China
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58066-85-6 MILTEFOSINE

  • MILTEFOSINE, 97%
  • China Suzhou Rovathin Foreign Trade Co.,Ltd [Manufacturer]
  • Tel: 86-512-65816829/ 86-512-61978430
  • Fax: 86-512-65816839
  • Address: Suzhou Rovathin Foreign Trade Co.,Ltd
    (Sales Company of Affiliated Plant in China)
    Room 603, 327 of ShiZi Street,
    Suzhou, Jiangsu, China 215006 ,China
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58066-85-6 Miltefosine

  • Miltefosine, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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58066-85-6 Miltefosine

  • Miltefosine, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,China
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58066-85-6 Miltefosine

  • MiltefosineHexadecylphosphocholine; Choline hexadecyl phosphateHePC
  • Switzerland Biosynth AG [Manufacturer]
  • Tel: +41 71 858 20 20/ 630.305.8400 (USA)
  • Fax: +41 71 858 20 30
  • Address: BIOSYNTH AG
    Rietlistrasse 4
    9422 Staad / Switzerland
    Phone: +41 (0)71 858 20 20
    Fax: +41 (0)71 858 20 30 ,Switzerland
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58066-85-6 Miltefosin

  • China Simag Chemicals [Manufacturer]
  • Tel: +86 592 2680277
  • Fax: +86 592 2680237
  • Address: Simag Chemicals
    A-9D Atlantic sea view city,
    No.9 Hubin West Rd.,
    Xiamen China. ,China
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58066-85-6 hexadecylphosphocholine

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58066-85-6 Miltefosine

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References of hexadecyl 2-(trimethylazaniumyl)ethyl phosphate
Title: Miltefosine
CAS Registry Number: 58066-85-6
CAS Name: 2-[[(Hexadecyloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethylethanaminium inner salt
Synonyms: choline phosphate hexadecyl ester, hydroxide, inner salt; hexadecyl 2-(N,N,N-trimethylamino)ethyl phosphate; n-hexadecylphosphorylcholine; hexadecylphosphocholine; HPC
Manufacturers' Codes: D-18506
Trademarks: Impavido (Zentaris); Miltex (Baxter)
Molecular Formula: C21H46NO4P
Molecular Weight: 407.57
Percent Composition: C 61.89%, H 11.38%, N 3.44%, O 15.70%, P 7.60%
Literature References: Synthetic phospholipid; affects cell-signaling pathways and membrane synthesis. Synthesis: U. Kaatze et al., Chem. Phys. Lipids 27, 263 (1980); W. J. Hansen et al., Lipids 17, 453 (1982). See also: H. Eibl, EP 225608; idem, US 4837023 (1987, 1989 both to Max-Planck Ges. Wissensch.). Toxicity and anticancer properties: C. Muschiol et al., Lipids 22, 930 (1987). Structure-activity study: M. R. Berger et al., Cancer Treat. Rev. 17, 143 (1990). HPTLC determn in plasma: I. Rustenbeck, S. Lenzen, J. Chromatogr. 525, 85 (1990). Clinical evaluation in topical treatment of cutaneous breast cancer metastases: C. Unger et al., Cancer Treat. Rev. 17, 243 (1990). Clinical trial in visceral leishmaniasis: S. Sundar et al., N. Engl. J. Med. 347, 1739 (2002). Review: H. Eibl, C. Unger, Cancer Treat. Rev. 17, 233-242 (1990).
Properties: mp 232-234° (dec); discoloration at 225°. LD50 in rats (mg/kg): 246 orally (Muschiol).
Melting point: mp 232-234° (dec)
Toxicity data: LD50 in rats (mg/kg): 246 orally (Muschiol)
Therap-Cat: Antineoplastic; antiprotozoal (Leishmania).
Keywords: Antineoplastic; Antiprotozoal (Leishmania).