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CAS No 57982-77-1 , Buserelin

  • Name: Buserelin
  • Synonyms: 1-9-(D-Ser(t-butyl))6-LH-releasing hormone ethylamide;? Buserelin;Buserelin;[D-Ser(tert-butyl)6,des-Gly-NH210]-LH-RH ethylamide;Luteinizinghormone-releasing factor (pig), 6-[O-(1,1-dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide-;Etilamide;Suprefact;Receptal;[D-Ser6(t-Bu),de-Gly10-NH2]-LH-RH ethylamide;
  • CAS Registry Number:
  • Density: 1.43 g/cmsup>3
  • Refractive index: 1.671
  • EINECS: 261-061-9
  • Molecular Weight: 1239.43
  • InChI: InChI=1/C60H86N16O13/c1-7-64-57(87)48-15-11-23-76(48)58(88)41(14-10-22-65-59(61)62)69-51(81)42(24-33(2)3)70-56(86)47(31-89-60(4,5)6)75-52(82)43(25-34-16-18-37(78)19-17-34)71-55(85)46(30-77)74-53(83)44(26-35-28-66-39-13-9-8-12-38(35)39)72-54(84)45(27-36-29-63-32-67-36)73-50(80)40-20-21-49(79)68-40/h8-9,12-13,16-19,28-29,32-33,40-48,66,77-78H,7,10-11,14-15,20-27,30-31H2,1-6H3,(H,63,67)(H,64,87)(H,68,79)(H,69,81)(H,70,86)(H,71,85)(H,72,84)(H,73,80)(H,74,83)(H,75,82)(H4,61,62,65)/t40-,41-,42-,43-,44-,45-,46-,47+,48-/m0/s1
  • Molecular Formula: C60H86N16O13
  • Molecular Structure:CAS No:57982-77-1 Buserelin

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References of Buserelin
Title: Buserelin
CAS Registry Number: 57982-77-1
CAS Name: 6-[O-(1,1-dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamideluteinizing hormone-releasing factor (pig)
Molecular Formula: C60H86N16O13
Molecular Weight: 1239.42
Percent Composition: C 58.14%, H 6.99%, N 18.08%, O 16.78%
Literature References: Synthetic nonapeptide agonist analog of LH-RH, q.v. Synthesis: W. Konig et al., DE 2438350; eidem, US 4024248 (1976, 1977 both to Hoechst); A. S. Dutta et al., J. Med. Chem. 21, 1018 (1978). Clinical pharmacology: A. Lemay et al., Fertil. Steril. 37, 193 (1982). Radioimmunoassay in plasma and urine: S. Saito et al., J. Immunol. Methods 79, 173 (1985). Veterinary use to increase conception rate: K. Moller, E. D. Fielden, N. Z. Vet. J. 29, 214 (1981). Clinical evaluation in prostatic carcinoma: J. H. Waxman, Br. J. Urol. 55, 737 (1983); as ovulatory stimulant for in vitro fertilization: V. MacLachlan et al., N. Engl. J. Med. 320, 1233 (1989). Review of pharmacokinetics and clinical profile: R. N. Brogden et al., Drugs 39, 399-437 (1990); of efficacy in prostatic carcinoma: H. J. de Voogt et al., Scand. J. Urol. Nephrol. Suppl 138, 131-136 (1991).
Properties: [a]D20 -40.4° (c = 1 in dimethylacetamide).
Optical Rotation: [a]D20 -40.4° (c = 1 in dimethylacetamide)
 
Derivative Type: Monoacetate
CAS Registry Number: 68630-75-1
Manufacturers' Codes: HOE-766
Trademarks: Receptal (Intervet); Suprecur (Sanofi-Aventis); Suprefact (Sanofi-Aventis)
Molecular Formula: C60H86N16O13.C2H4O2
Molecular Weight: 1299.48
Percent Composition: C 57.30%, H 6.98%, N 17.25%, O 18.47%
 
Therap-Cat: Antineoplastic (hormonal). Gonad-stimulating principle.
Therap-Cat-Vet: Gonad-stimulating principle.
Keywords: Antineoplastic (Hormonal); LH-RH Analogs; Gonad-Stimulating Principle; LH-RH Agonist.