Title: Triptorelin
CAS Registry Number: 57773-63-4
CAS Name: 6-D-Tryptophanluteinizing hormone-releasing factor (pig)
Synonyms: 6-D-tryptophan-LH-RH; D-trp6-LHRH; D-Trp6LRH; D-trp6-gonadorelin; détryptoréline
Manufacturers' Codes: AY-25650; Wy-42462; Wy-42422
Molecular Formula: C64H82N18O13
Molecular Weight: 1311.45
Percent Composition: C 58.61%, H 6.30%, N 19.22%, O 15.86%
Literature References: Synthetic peptide agonist analog of LH-RH,
q.v. Prepn: A. V. Schally, D. H. Coy,
DE 2625843;
eidem, US 4010125 (1976, 1977); D. H. Coy
et al., J. Med. Chem. 19, 423 (1976). Comparison with LH-RH of
in vitro activity: D. H. Coy
et al., Biochem. Biophys. Res. Commun. 67, 576 (1975). Pharmacokinetics and metabolism in humans: J. L. Barron
et al., J. Clin. Endocrinol. Metab. 54, 1169 (1982). HPLC analysis: D. C. Serti
et al., J. Liq. Chromatogr. 4, 1135 (1981). RIA in human serum: M. Mason-Garcia
et al., Proc. Natl. Acad. Sci. USA 82, 1547 (1985). Clinical trial for
in vitro fertilization: A. Hazout
et al., Fertil. Steril. 59, 596 (1993). Clinical trial in prostate cancer: C. F. Heyns
et al.,
BJU Int.
92, 226 (2003); in severe endometriosis: A. Y. K. Wong, L. Tang,
Fertil. Steril. 81, 1522 (2004).
Properties: Fluffy, white solid. [a]D23 -58.8° (c = 0.33 in acetic acid).
Optical Rotation: [a]D23 -58.8° (c = 0.33 in acetic acid)
Derivative Type: Acetate
CAS Registry Number: 140194-24-7
Trademarks: Gonapeptyl (Ferring)
Molecular Formula: C64H82N18O13.C2H4O2
Molecular Weight: 1371.50
Percent Composition: C 57.80%, H 6.32%, N 18.38%, O 17.50%
Derivative Type: Pamoate
CAS Registry Number: 124508-66-3
Trademarks: Decapeptyl (Ipsen); Trelstar (Watson)
Molecular Formula: C64H82N18O13.C23H16O6
Molecular Weight: 1699.82
Percent Composition: C 61.47%, H 5.81%, N 14.83%, O 17.88%
Therap-Cat: Antineoplastic (hormonal); in treatment of endometriosis and infertility.
Keywords: Antineoplastic (Hormonal); LH-RH Analogs; LH-RH Agonist.
