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CAS No 57773-63-4 , Triptorelin

  • Name: Triptorelin
  • Synonyms: AY25650;Triptorelin;BIM 21003;CL 118532;6-D-Tryptophan-LH-RH;D-Tryptophan6-LH-RH;Luteinizinghormone-releasing factor (pig), 6-D-tryptophan-;
  • CAS Registry Number:
  • Density: 1.52 g/cm3
  • Safety Statements: 53-22-36/37/39-45
  • Hazard Symbols: T: Toxic;
  • Molecular Weight: 1311.46
  • InChI: InChI=1/C64H82N18O13/c1-34(2)23-46(56(88)75-45(13-7-21-69-64(66)67)63(95)82-22-8-14-52(82)62(94)72-31-53(65)85)76-58(90)48(25-36-28-70-42-11-5-3-9-40(36)42)78-57(89)47(24-35-15-17-39(84)18-16-35)77-61(93)51(32-83)81-59(91)49(26-37-29-71-43-12-6-4-10-41(37)43)79-60(92)50(27-38-30-68-33-73-38)80-55(87)44-19-20-54(86)74-44/h3-6,9-12,15-18,28-30,33-34,44-52,70-71,83-84H,7-8,13-14,19-27,31-32H2,1-2H3,(H2,65,85)(H,68,73)(H,72,94)(H,74,86)(H,75,88)(H,76,90)(H,77,93)(H,78,89)(H,79,92)(H,80,87)(H,81,91)(H4,66,67,69)
  • Risk Statements: 60
  • Molecular Formula: C64H82N18O13
  • Molecular Structure:CAS No:57773-63-4 Triptorelin

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References of Triptorelin
Title: Triptorelin
CAS Registry Number: 57773-63-4
CAS Name: 6-D-Tryptophanluteinizing hormone-releasing factor (pig)
Synonyms: 6-D-tryptophan-LH-RH; D-trp6-LHRH; D-Trp6LRH; D-trp6-gonadorelin; détryptoréline
Manufacturers' Codes: AY-25650; Wy-42462; Wy-42422
Molecular Formula: C64H82N18O13
Molecular Weight: 1311.45
Percent Composition: C 58.61%, H 6.30%, N 19.22%, O 15.86%
Literature References: Synthetic peptide agonist analog of LH-RH, q.v. Prepn: A. V. Schally, D. H. Coy, DE 2625843; eidem, US 4010125 (1976, 1977); D. H. Coy et al., J. Med. Chem. 19, 423 (1976). Comparison with LH-RH of in vitro activity: D. H. Coy et al., Biochem. Biophys. Res. Commun. 67, 576 (1975). Pharmacokinetics and metabolism in humans: J. L. Barron et al., J. Clin. Endocrinol. Metab. 54, 1169 (1982). HPLC analysis: D. C. Serti et al., J. Liq. Chromatogr. 4, 1135 (1981). RIA in human serum: M. Mason-Garcia et al., Proc. Natl. Acad. Sci. USA 82, 1547 (1985). Clinical trial for in vitro fertilization: A. Hazout et al., Fertil. Steril. 59, 596 (1993). Clinical trial in prostate cancer: C. F. Heyns et al., BJU Int. 92, 226 (2003); in severe endometriosis: A. Y. K. Wong, L. Tang, Fertil. Steril. 81, 1522 (2004).
Properties: Fluffy, white solid. [a]D23 -58.8° (c = 0.33 in acetic acid).
Optical Rotation: [a]D23 -58.8° (c = 0.33 in acetic acid)
 
Derivative Type: Acetate
CAS Registry Number: 140194-24-7
Trademarks: Gonapeptyl (Ferring)
Molecular Formula: C64H82N18O13.C2H4O2
Molecular Weight: 1371.50
Percent Composition: C 57.80%, H 6.32%, N 18.38%, O 17.50%
 
Derivative Type: Pamoate
CAS Registry Number: 124508-66-3
Trademarks: Decapeptyl (Ipsen); Trelstar (Watson)
Molecular Formula: C64H82N18O13.C23H16O6
Molecular Weight: 1699.82
Percent Composition: C 61.47%, H 5.81%, N 14.83%, O 17.88%
 
Therap-Cat: Antineoplastic (hormonal); in treatment of endometriosis and infertility.
Keywords: Antineoplastic (Hormonal); LH-RH Analogs; LH-RH Agonist.