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CAS No 57576-44-0 , aclarubicin free base

  • Name: aclarubicin free base
  • Synonyms: Aclarubicin; Aclacinomycin A, Streptomycesgalilaeus;aclarubicin free base;
  • CAS Registry Number:
  • Transport: 3249
  • Density: 1.42 g/cm3
  • Refractive index: 1.629
  • Safety Statements: Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. An eye and subcutaneous irritant. When heated to decomposition it emits toxic fumes of NOx.
  • Hazard Symbols: T
  • EINECS: 260-824-3
  • Molecular Weight: 811.87
  • InChI: InChI=1/C42H53NO15/c1-8-42(51)17-28(33-22(35(42)41(50)52-7)14-23-34(38(33)49)37(48)32-21(36(23)47)10-9-11-26(32)45)56-30-15-24(43(5)6)39(19(3)54-30)58-31-16-27(46)40(20(4)55-31)57-29-13-12-25(44)18(2)53-29/h9-11,14,18-20,24,27-31,35,39-40,45-46,49,51H,8,12-13,15-17H2,1-7H3/t18-,19-,20-,24?,27-,28-,29-,30-,31-,35-,39+,40+,42+/m0/s1
  • Risk Statements: 25
  • Molecular Formula: C42H53NO15
  • Molecular Structure:CAS No:57576-44-0 aclarubicin free base
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57576-44-0 aclarubicin free base

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57576-44-0 Aclarubicin

  • Aclarubicin
  • China Sunkingchem Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-28-88007744
  • Fax: +86-28-85193812
  • Address: A-703, Gaofa Building, Jiuxing Road 6#, Hi-Tech Zone 610041, Chengdu, Sichuan, China.610041 ChengduCHINA Chengdu,nullChina
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57576-44-0 Aclarublcin

  • Aclarublcin, 99,00%
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
  • Fax: +86-25-85612276
  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,nullChina
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57576-44-0 Aclarubicin

  • China Trust&We Co., Ltd. [Manufacturer]
  • Tel: +86-21-61044582
  • Fax: +86-21-61044583
  • Address: 1-102,No.11,Dongjiaominxiang Alley,
    Dongcheng District,
    Beijing 100005,China null,nullChina
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57576-44-0 ACLARUBICIN

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong null,nullHong kong
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57576-44-0 Aclacinomycin A

  • Aclacinomycin A, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
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57576-44-0 Aclarubicin

  • Aclarubicin, 99%UP
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,nullChina
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57576-44-0 Aclarubicin

  • China Shanghai Xunxin Chemical Co., Ltd [Manufacturers]
  • Tel: +86-(21)-38218795
  • Fax: +86-(21)-38218795
  • Address: 580 Lane, Kanghong Road, Pudong New District, Shanghai 201315, Shanghai,ShanghaiChina
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57576-44-0 Aclarubicin

  • China Hangzhou Sage Chemical Co., Ltd. [Manufacturer]
  • Tel: +86-571-86818502
  • Fax: +86-571-86818503
  • Address: RM501 Tower A, New Youth Plaza, NO.8 Jia Shan Road, Hangzhou, Zhejiang 310014, null,ZhejiangChina
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57576-44-0 Aclarubicin

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 null,nullUnited States
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References of aclarubicin free base
Title: Aclacinomycins
Literature References: Antitumor antibiotic complex of the anthracycline group, produced by Streptomyces galilaeus. Thirteen yellow and seven red-colored components have been identified. Isoln of the major components, aclacinomycins A and B: H. Umezawa et al., DE 3532568; eidem, US 3988315 (1974, 1976 both to Microbiochem. Res. Found.). See also: T. Oki et al., J. Antibiot. 28, 830 (1975). Structure, taxonomy, production, properties: eidem, ibid. 32, 791, 801 (1979). The aglycone portion of aclacinomycin A is known as aklavinone. Isoln of aklavinone: J. J. Gordon et al., Tetrahedron Lett. 8, 28 (1960). Synthesis of racemic aklavinone: B. A. Pearlman et al., J. Am. Chem. Soc. 103, 4248 (1981); P. A. Confalone, G. Pizzolato, ibid. 4251; R. K. Boeckman, F. W. Sum, ibid. 104, 4604 (1982). Synthesis of optically active aklavinone: A. S. Kende, J. P. Rizzi, ibid. 103, 4247 (1981); J. M. McNamara, Y. Kishi, ibid. 104, 7371 (1982). In vitro metabolism of aclacinomycins: T. Komiyama et al., Gann 70, 395 (1979), C.A. 92, 15143x (1980). HPLC determn of aclacinomycin A and its metabolites: T. Ogasawara et al., J. Antibiot. 34, 47, 52 (1981). Pharmacokinetics: M. J. Egorin et al., Cancer Chemother. Pharmacol. 8, 41 (1982). Series of articles on absorption, excretion, distribution and general pharmacology: Jpn. J. Antibiot. 33, 169-213 (1980), C.A. 93, 19316, 125326, 125649, 142986 (1980). Immunological study: M. Ishizuka et al., J. Antibiot. 34, 331 (1981). Clinical studies: R. Maral, Drugs Exp. Clin. Res. 9, 375 (1983); R. P. Warrell, Jr., S. J. Kempin, Am. J. Clin. Oncol. 6, 81 (1983); A. Y. Bedikian et al., ibid. 187 (1983). Review of pharmacology of aclacinomycin A: T. Oki, Anthracyclines [Proc. Workshop], S. T. Crooke, S. D. Reich, Eds. (Academic Press, New York, 1980) pp 323-342, C.A. 93, 160778h (1980).
 
Derivative Type: Aclacinomycin A
CAS Registry Number: 57576-44-0
CAS Name: [1R-(1a,2b,4b)]-2-Ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-a-L-lyxo-hexopyranosyl]-3-(dimethylamino)-a-L-lyxo-hexopyranosyl]oxy]-1-naphthacenecarboxylic acid methyl ester
Synonyms: aclarubicin; antibiotic MA 144A1
Manufacturers' Codes: NSC-208734
Trademarks: Jaclacin (Medac)
Molecular Formula: C42H53NO15
Molecular Weight: 811.87
Percent Composition: C 62.13%, H 6.58%, N 1.73%, O 29.56%
Properties: Yellow microcryst powder from chloroform/hexane, mp 151-153° (dec). [a]D24 -11.5° (c = 1 in methylene chloride). uv max (methanol): 229.5, 259, 289.5, 431 nm (E1%1cm 550, 326, 135, 161); (0.1N HCl) 229.5, 258.5, 290, 431 nm (E1%1cm 571, 338, 130, 161); (0.1N NaOH) 239, 287, 523 nm (E1%1cm 450, 113, 127). Sol in CHCl3, ethyl acetate. Insol in ethyl ether, n-hexane, petr ether. Addn of alkali to aq solns gives an intense reddish-purple color; in conc HCl the soln is yellow. LD50 in mice (mg/kg): 22.6 i.p., 33.7 i.v. (Oki).
Melting point: mp 151-153° (dec)
Optical Rotation: [a]D24 -11.5° (c = 1 in methylene chloride)
Absorption maximum: uv max (methanol): 229.5, 259, 289.5, 431 nm (E1%1cm 550, 326, 135, 161); (0.1N HCl) 229.5, 258.5, 290, 431 nm (E1%1cm 571, 338, 130, 161); (0.1N NaOH) 239, 287, 523 nm (E1%1cm 450, 113, 127)
Toxicity data: LD50 in mice (mg/kg): 22.6 i.p., 33.7 i.v. (Oki)
 
Derivative Type: Aclacinomycin A hydrochloride
Synonyms: Aclarubicin hydrochloride
Trademarks: Aclacin (Lundbeck); Aclacinon (Yamanouchi); Aclaplastin (Medac)
Molecular Formula: C42H53NO15.HCl
Molecular Weight: 848.33
Percent Composition: C 59.46%, H 6.42%, N 1.65%, O 28.29%, Cl 4.18%
 
Derivative Type: Aclacinomycin B
CAS Registry Number: 57596-79-9
CAS Name: [1R-(1a,2b,4b)]-4-[[[2¢¢¢,3¢¢-Anhydro]-O-3,6-dideoxy-a-L-erythro-hexopyranos-4-ulos-1-yl-(1?4)-O-2,6-dideoxy-a-L-lyxo-hexopyranosyl-(1?4)-2,3,6-trideoxy-3-(dimethylamino)-a-L-lyxo-hexopyranosyl]oxy]-2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-1-naphthacenecarboxylic acid methyl ester
Synonyms: antibiotic MA 144B1
Molecular Formula: C42H51NO15
Molecular Weight: 809.85
Percent Composition: C 62.29%, H 6.35%, N 1.73%, O 29.63%
Properties: Yellow microcryst powder from chloroform/hexane, mp 163-167° (dec). [a]D24 +3° (c = 1 in methylene chloride). Other physical properties similar to aclacinomycin A. LD50 in mice (mg/kg): 13.7 i.p., 16.4 i.v. (Oki).
Melting point: mp 163-167° (dec)
Optical Rotation: [a]D24 +3° (c = 1 in methylene chloride)
Toxicity data: LD50 in mice (mg/kg): 13.7 i.p., 16.4 i.v. (Oki)
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antibiotics and Analogs; Anthracyclines.