Home > Name List By 3 > 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl] oxyethyl]piperazin-1-yl]propyl 4-benzamido-5-(dipropylam...

CAS No 57132-53-3 , 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]
oxyethyl]piperazin-1-yl]propyl
4-benzamido-5-(dipropylamino)-5-oxopentanoate

  • Name: 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]
    oxyethyl]piperazin-1-yl]propyl
    4-benzamido-5-(dipropylamino)-5-oxopentanoate
  • Synonyms: Proglumetacinum; Proglumetacina; proglumetacin maleate; Proglumetacine; NCGC00183024-01; Bruxel (TN);57132-53-3; Proglumetacin (INN);3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]
    oxyethyl]piperazin-1-yl]propyl
    4-benzamido-5-(dipropylamino)-5-oxopentanoate;
  • CAS Registry Number:
  • Density: 1.22 g/cm3
  • Refractive index: 1.592
  • EINECS: 261-656-3
  • Molecular Weight: 844.43442
  • InchiKey: PTXGHCGBYMQQIG-UHFFFAOYSA-N
  • InChI: InChI=1S/C46H58ClN5O8/c1-5-21-51(22-6-2)46(57)40(48-44(55)34-11-8-7-9-
    12-34)18-20-42(53)59-29-10-23-49-24-26-50(27-25-49)28-30-60-43(54)32-38-
    33(3)52(41-19-17-37(58-4)31-39(38)41)45(56)35-13-15-36(47)16-14-35/h7-9,
    11-17,19,31,40H,5-6,10,18,20-30,32H2,1-4H3,(H,48,55)
  • Molecular Formula: C46H58ClN5O8
  • Molecular Structure:CAS No:57132-53-3 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]<br />oxyethyl]piperazin-1-yl]propyl<br />4-benzamido-5-(dipropylamino)-5-oxopentanoate

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57132-53-3 1H-Indole-3-aceticacid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-,2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethylester

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57132-53-3 proglumetacin

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57132-53-3 PROGLUMETACIN

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
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References of 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]
oxyethyl]piperazin-1-yl]propyl
4-benzamido-5-(dipropylamino)-5-oxopentanoate
Title: Proglumetacin
CAS Registry Number: 57132-53-3
CAS Name: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester
Synonyms: (±)-N-[2-[1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetoxy]ethyl]-N￠-[3-(N-benzoyl-N￠,N￠-di-n-propyl-DL-isoglutaminoyl)oxypropyl]piperazine
Molecular Formula: C46H58ClN5O8
Molecular Weight: 844.43
Percent Composition: C 65.43%, H 6.92%, Cl 4.20%, N 8.29%, O 15.16%
Literature References: Deriv of indomethacin, q.v. Prepn: F. Makovec et al., DE 2535799 corresp to US 3985878 (both 1976 to Rotta). Series of articles on pharmacology, mechanism of action, safety: Arzneim.-Forsch. 29, 1116-1129 (1979). Bioavailability study: A. A. Bignamini, P. L. Casula, Curr. Med. Res. Opin. 6, 299 (1979). Clinical evaluation: J. Münzenberg, S. Tachibana, Pharmatherapeutica 2, 279 (1980); P. Loizzi et al., ibid. 285. Mutagenicity study: R. Vidal y Plana et al., Farmaco Ed. Prat. 33, 543 (1978). Toxicity data for dimaleate: A. L. Rovati et al., Arzneim.-Forsch. 29, 1116 (1979).
 
Derivative Type: Dimaleate
CAS Registry Number: 59209-40-4
Synonyms: Protacine
Manufacturers' Codes: CR-604
Trademarks: Afloxan (Rottapharm); Miridacin (Taiho); Protaxon (Opfermann); Proxil (Rottapharm)
Molecular Formula: C46H58ClN5O8.2C4H4O4
Molecular Weight: 1076.58
Percent Composition: C 60.24%, H 6.18%, Cl 3.29%, N 6.51%, O 23.78%
Properties: Crystals from ethanol, mp 146-148°. LD50 in male mice, rats (mg/kg): 262, 450 orally (Rovati).
Melting point: mp 146-148°
Toxicity data: LD50 in male mice, rats (mg/kg): 262, 450 orally (Rovati)
 
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives.