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CAS No 56995-20-1 , ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate

  • Name: ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate
  • Synonyms: EINECS 260-503-8; Flupirtinum [INN-Latin];Flupirtine [INN:BAN]; flupirtin maleate; Flupirtino [INN-Spanish];ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate; D 9998; 56995-20-1;
  • CAS Registry Number:
  • Melting Point: 115 - 116
  • Flash Point: 216.8°C
  • Boiling Point: 434.9°Cat760mmHg
  • Density: 1.35g/cm3
  • Refractive index: 1.661
  • Flash Point: 216.8°C
  • EINECS: 260-503-8
  • Molecular Weight: 304.319483
  • InchiKey: JUUFBMODXQKSTD-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H17FN4O2/c1-2-22-15(21)19-12-7-8-13(20-14(12)17)18-9-10-3-5-
    11(16)6-4-10/h3-8H,2,9H2,1H3,(H,19,21)(H3,17,18,20)
  • Molecular Formula: C15H17FN4O2
  • Molecular Structure:CAS No:56995-20-1 ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate

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56995-20-1 FLUPIRTINE

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56995-20-1 Carbamic acid,N-[2-amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-, ethyl ester

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56995-20-1 Flupirtine

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56995-20-1 Flupirtine

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56995-20-1 Flupirtine, 99%

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56995-20-1 FLUPIRTINE

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56995-20-1 Flupirtine

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References of ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate
Title: Flupirtine
CAS Registry Number: 56995-20-1
CAS Name: [2-Amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamic acid ethyl ester
Synonyms: 2-amino-6-[(p-fluorobenzyl)amino]-3-pyridinecarbamic acid ethyl ester
Trademarks: D-9998
Molecular Formula: C15H17FN4O2
Molecular Weight: 304.32
Percent Composition: C 59.20%, H 5.63%, F 6.24%, N 18.41%, O 10.51%
Literature References: Substituted pyridine with central analgesic properties. Prepn: K. Thiele, W. von Bebenburg, ZA 6902364 (1970 to Degussa); W. von Bebenburg et al., Chem. Ztg. 103, 387 (1979); eidem, ibid. 105, 217 (1981). Prepn of maleate: W. von Bebenburg, S. Pauluhn, BE 890331; eidem, US 4481205 (1980, 1984 both to Degussa). Comparison of pharmacology with other analgesics: V. Jakovlev et al., Arzneim.-Forsch. 35, 30 (1985). Pharmacokinetic studies: K. Obermeier et al., ibid. 60. Effect on driving ability: B. Biehl, ibid. 77. Clinical trials in treatment of cancer pain: W. Scheef, D. Wolf-Gruber, ibid. 75. Efficacy in treatment of pain after hysterectomy: R. A. Moore et al., Br. J. Anaesth. 55, 429 (1983). Symposium on pharmacology and clinical efficacy: Postgrad. Med. J. 63, Suppl. 3, 1-113 (1987).
Properties: Crystals from isopropanol, mp 115-116°. 5% ethanol soln is colorless, turns green on exposure to air for 20 hours. LD50 orally in mice, rats: 617, 1660 mg/kg (Jakovlev).
Melting point: mp 115-116°
Toxicity data: LD50 orally in mice, rats: 617, 1660 mg/kg (Jakovlev)
 
Derivative Type: Hydrochloride
Molecular Formula: C15H17FN4O2.HCl
Molecular Weight: 340.78
Percent Composition: C 52.87%, H 5.32%, F 5.57%, N 16.44%, O 9.39%, Cl 10.40%
Properties: Crystals from water, mp 214-215°. When prepd industrially contains intensely blue by-product.
Melting point: mp 214-215°
 
Derivative Type: Maleate
CAS Registry Number: 75507-68-5
Trademarks: Katadolon (AWD)
Molecular Formula: C15H17FN4O2.C4H4O4
Molecular Weight: 420.39
Percent Composition: C 54.28%, H 5.04%, F 4.52%, N 13.33%, O 22.84%
Properties: Colorless crystals from isopropanol, mp 175.5-176°. Formed as mixture of two crystalline forms A and B; mixtures containing 60-90% A are preferred.
Melting point: mp 175.5-176°
 
Therap-Cat: Analgesic.
Keywords: Analgesic (Non-Narcotic).