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CAS No 569-65-3 , 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine Search by region : China

  • Name: 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine
  • Synonyms: Histametizine; Bonadettes; Parachloramine; Calmonal;Meclozine; Bonine; Chiclida;1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine; Histametizyne; Histamethizine;
  • CAS Registry Number:
  • Density: 1.159 g/cm3
  • Water Solubility: 1.03e-03 mg/mL in water
  • Safety Statements: R22;R36/37/38,
  • Hazard Symbols: Xn:;
  • EINECS: 209-323-3
  • Molecular Weight: 390.94828
  • InchiKey: OCJYIGYOJCODJL-UHFFFAOYSA-N
  • InChI: InChI=1S/C25H27ClN2/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-
    8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2-13,18,25H,14-17,19H2,1H3
  • Risk Statements: S26;S37/39,
  • Molecular Formula: C25H27ClN2
  • Molecular Structure:CAS No:569-65-3 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine

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References of 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine
Title: Meclizine
CAS Registry Number: 569-65-3
CAS Name: 1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine
Synonyms: 1-(p-chloro-a-phenylbenzyl)-4-(m-methylbenzyl)piperazine; 1-(p-chlorobenzhydryl)-4-(m-methylbenzyl)piperazine; 1-(p-chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine; meclozine; parachloramine
Molecular Formula: C25H27ClN2
Molecular Weight: 390.95
Percent Composition: C 76.80%, H 6.96%, Cl 9.07%, N 7.17%
Literature References: Synthesis: Morren, BE 502889 (1951); GB 705979 (1954), US 2709169 (1955 to U.C.B.). Outline of reactions: Grivsky, Ind. Chim. Belge 17, 735 (1952). Clinical evaluation in vertigo: B. Cohen, J. M. B. Vianney de Jong, Arch. Neurol. 27, 129 (1972).
Properties: bp2 230°.
Boiling point: bp2 230°
 
Derivative Type: Dihydrochloride monohydrate
CAS Registry Number: 31884-77-2
Manufacturers' Codes: UCB-5062
Trademarks: Ancolan (Boots); Antivert (Pfizer); Bonamine (Pfizer); Bonine (Insight); Calmonal (BMS); Peremesin (BMS); Postafen (UCB)
Molecular Formula: C25H27ClN2.2HCl.H2O
Molecular Weight: 481.89
Percent Composition: C 62.31%, H 6.48%, Cl 22.07%, N 5.81%, O 3.32%
Properties: Freely sol in chloroform, pyridine; slightly sol in dil acids, alc. Practically insol in water (0.1 gm/100 ml), ether.
 
Therap-Cat: Antiemetic.
Therap-Cat-Vet: Antiemetic.
Keywords: Antiemetic.