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CAS No 56377-79-8 , Nosiheptide

  • Name: Nosiheptide
  • Synonyms: Nosiheptide;N-[1-(Aminocarbonyl)ethenyl]-2-[(11S,14Z,21S,23S,29S)-14-ethylidene-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-3,23-dihydroxy-11-[(1R)-1-hydroxyethyl]-31-methyl-9,12,19,24,33,43-hexaoxo-30,32-imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endo-thiazolomethanimino)-5H,15H,37H-pyrido[3,2-w][2,11,21,27,31,7,14,17]benzoxatetrathiatriazacyclohexatriacontin-2-yl]-4-thiazolecarboxamide;
  • CAS Registry Number:
  • Density: 1.534 g/cm3
  • Refractive index: 1.698
  • EINECS: 260-138-4
  • Molecular Weight: 1222.36
  • InChI: InChI=1/C51H43N13O12S6/c1-5-23-46-60-28(14-79-46)41(70)56-25-10-33(67)50(74)76-11-21-7-6-8-24-34(21)18(2)35(54-24)51(75)82-17-31(57-42(71)29-15-80-47(25)61-29)48-58-26(12-78-48)37-22(45-59-30(13-77-45)43(72)64-36(20(4)65)44(73)55-23)9-32(66)38(63-37)49-62-27(16-81-49)40(69)53-19(3)39(52)68/h5-9,12-16,20,25,31,33,36,54,65-67H,3,10-11,17H2,1-2,4H3,(H2,52,68)(H,53,69)(H,55,73)(H,56,70)(H,57,71)(H,64,72)/b23-5-
  • Molecular Formula: C51H43N13O12S6
  • Molecular Structure:CAS No:56377-79-8 Nosiheptide

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56377-79-8 NOSIHEPTIDE (MULTHIOMYCIN, TAITOMYCIN)

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56377-79-8 Nosiheptide

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56377-79-8 NOSIHEPTIDE

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References of Nosiheptide
Title: Nosiheptide
CAS Registry Number: 56377-79-8
Synonyms: Multhiomycin
Manufacturers' Codes: RP-9671
Trademarks: Primofax (Rh>e-Poulenc)
Molecular Formula: C51H43N13O12S6
Molecular Weight: 1222.36
Percent Composition: C 50.11%, H 3.55%, N 14.90%, O 15.71%, S 15.74%
Literature References: Polythiazole antibiotic produced by Streptomyces actuosus. Isoln and characterization: S. Pinnert et al., FR 1392453; eidem, US 3155581 (1961, 1964 both to Rh?ne-Poulenc); F. Benazet et al., Experientia 36, 414 (1980). NMR determination of mol wt and elemental formula: H. Depaire et al., Tetrahedron Lett. 1977, 1397, 1401. Structure and configuration: T. Prange et al., Nature 265, 189 (1977); C. Pascard et al., J. Am. Chem. Soc. 99, 6418 (1977). Biosynthetic study: D. P. Houck et al., ibid. 109, 1250 (1987). Identity with multhiomycin: T. Endo, H. Yonehara, J. Antibiot. 31, 623 (1978). Mode of action: E. Cundliffe, J. Thompson, J. Gen. Microbiol. 126, 185 (1981). Review: F. Benazet et al., Experientia 36, 414-416 (1980).
Properties: Yellow needles, mp 310-320° (dec). [a]D20 +38° (c = 1 in pyridine). uv max (water/DMF): 242, 322 nm (E1%1cm 525, 229). Sol in chloroform, dioxane, pyridine, DMF, DMSO; slightly sol in methanol, ethanol, ethyl acetate, benzene. Insol in water and petr ether.
Melting point: mp 310-320° (dec)
Optical Rotation: [a]D20 +38° (c = 1 in pyridine)
Absorption maximum: uv max (water/DMF): 242, 322 nm (E1%1cm 525, 229)
Therap-Cat-Vet: Antibacterial; growth promotant.