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CAS No 56287-74-2 , 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one

  • Name: 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one
  • Synonyms: HQ 495;Arofuto; Afloqualonum [INN-Latin]; BRN 0819769; Afloqualona [INN-Spanish]; Aroft; Afloqualon;6-amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one; 56287-74-2;
  • CAS Registry Number:
  • Melting Point: 195-196 ºC
  • Density: 1.31 g/cm3
  • Refractive index: 1.642
  • Safety Statements: Poison by ingestion and intraperitoneal routes. Moderately toxic by other routes. When heated to decomposition it emits toxic fumes of F− and NOx.
  • Molecular Weight: 283.300263
  • InchiKey: VDOSWXIDETXFET-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12
    (13)16(20)21/h2-8H,9,18H2,1H3
  • Molecular Formula: C16H14FN3O
  • Molecular Structure:CAS No:56287-74-2 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one

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56287-74-2 4(3H)-Quinazolinone,6-amino-2-(fluoromethyl)-3-(2-methylphenyl)-

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56287-74-2 Afloqualone

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References of 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one
Title: Afloqualone
CAS Registry Number: 56287-74-2
CAS Name: 6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)-4(3H)-quinazolinone
Synonyms: 6-amino-2-fluoromethyl-3-(o-tolyl)-4(3H)-quinazolinone
Manufacturers' Codes: HQ-495
Trademarks: Arofuto (Tanabe)
Molecular Formula: C16H14FN3O
Molecular Weight: 283.30
Percent Composition: C 67.83%, H 4.98%, F 6.71%, N 14.83%, O 5.65%
Literature References: A centrally acting muscle relaxant. Prepn: I. Inoue et al., DE 2449113; eidem, US 3966731 (1975, 1976 to Tanabe); J. Tani et al., J. Med. Chem. 22, 95 (1979). Pharmacology: T. Ochiai, R. Ishida, Jpn. J. Pharmacol. 31, 491 (1981); 32, 427 (1982). Metabolism: N. Otsuka et al., J. Pharmacobio-Dyn. 5, S-59 (1982); S. Furuuchi et al., Drug Metab. Dispos. 11, 371 (1983).
Properties: Pale yellow prisms from 2-propanol, mp 195-196°. LD50 in mice (mg/kg): 315.1 i.p. (Tani).
Melting point: mp 195-196°
Toxicity data: LD50 in mice (mg/kg): 315.1 i.p. (Tani)
Therap-Cat: Muscle relaxant (skeletal).
Keywords: Muscle Relaxant (Skeletal).