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CAS No 56211-40-6 , 1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea

  • Name: 1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea
  • Synonyms: 56211-40-6; Luprac; Torasemida [INN-Spanish]; Torasemidum;1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea; Torasemida; Torasemidum [INN-Latin]; Demadex;Torasemide;
  • CAS Registry Number:
  • Melting Point: 163-164 ºC
  • Density: 1.283 g/cm3
  • Refractive index: 1.594
  • Safety Statements: 26-37/39
  • Hazard Symbols: Xi: Irritant;
  • Molecular Weight: 348.42
  • InchiKey: NGBFQHCMQULJNZ-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,
    23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,
    18,20,21)
  • Risk Statements: 36-36/37/38
  • Molecular Formula: C16H20N4O3S
  • Molecular Structure:CAS No:56211-40-6 1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea
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56211-40-6 Torsemide(Demadex)

  • Torsemide(Demadex) is a pyridine-sulfonyl urea type loop diuretic with an IC50 of 2.7 uM. Furosemide is the most widely prescribed loop diuretic in the setting of systolic heart failure (HF), yet torsemide has been shown to have less inter- and intra...
  • Min. Order: 10
  • United States Creative Enzymes [Manufacturer]
  • Tel: 1-516-6698109
  • Fax: 1-631-9388127
  • Address: 45-1 Ramsey Road, Shirley New York,New YorkUnited States
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56211-40-6 Torasemide

  • Product Name: Torasemide Synonyms: AC-4464;1-[4-(3-methylphenyl)aminopyridin-3-yl]sulfonyl-3-propan-2-yl-urea;DEMADEX;JDL-464;BM-02015;LUPLAC;N-[[(1-METHYLETHYL)AMINO]CARBONYL]-4-[(3-METHYLPHENYL)AMINO]-3-PYRIDINESULFONAMIDE;TORADIUR CAS: 56211-40-6 ...
  • Min. Order: 500
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  • China Wuhan Hezhong Bio-Chemical Manufature Co.,Ltd [Manufacturer]
  • Tel: 86-27-50756046
  • Address: Zhongshan Road No 496 Wuhan,HubeiChina
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56211-40-6 Torasemide

  • Product Name: Torasemide Synonyms: AC-4464;1-[4-(3-methylphenyl)aminopyridin-3-yl]sulfonyl-3-propan-2-yl-urea;DEMADEX;JDL-464;BM-02015;LUPLAC;N-[[(1-METHYLETHYL)AMINO]CARBONYL]-4-[(3-METHYLPHENYL)AMINO]-3-PYRIDINESULFONAMIDE;TORADIUR CAS: 56211-40-6 ...
  • Min. Order: 100
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  • China Wuhan Yuancheng Gongchuang Technology Co.Ltd. [Manufacturer]
  • Tel: 86-27-50756064
  • Address: No.496,Zhongshan Road, Wuhan, Hubei, China Wuhan,HubeiChina
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56211-40-6 Torasemide

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56211-40-6 Torasemide

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi ,ShanXiChina
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56211-40-6 Torasemide

  • United States HBCChem, Inc. [Manufacturers]
  • Tel: +1-510-219-6317
  • Fax: +1-510-675-0318
  • Address: Union City,CaliforniaUnited States
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56211-40-6 Torsemide

  • Torsemide
  • China Betapharma Shanghai Inc.Co., Ltd [Manufacturer]
  • Tel: 86-21-62951620
  • Fax: 86-21-32230794
  • Address: Jinming Building 12A No. 8 Zunyi(S) Rd. Shanghai China 200336 shanghaiCHINA shanghai,China
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56211-40-6 TORASEMIDE

  • TORASEMIDE
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
  • Fax: +86-25-85612276
  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,China
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56211-40-6 Torsemide

  • Torsemide
  • China Shanghai Synnad Chemical Co., Ltd. [Importer/Exporter]
  • Tel: 86 21 5109 7911
  • Fax: 86 21 5109 7955
  • Address: B-5 Ecust Science Park, No. 18, Lane 1305, Hua Jing Road, Shanghai 200231 China Shanghai,ShanghaiChina
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56211-40-6 Torasemide

  • Torasemide
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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References of 1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea
Title: Torsemide
CAS Registry Number: 56211-40-6
CAS Name: N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide
Synonyms: 1-isopropyl-3-[(4-m-toluidino-3-pyridyl)sulfonyl]urea; 3-isopropylcarbamylsulfonamido-4-(3¢-methylphenyl)aminopyridine; torasemide
Manufacturers' Codes: AC-4464; BM-02015; JDL-464
Trademarks: Demadex (Roche); Toradiur (Roche); Torem (Roche); Unat (Roche)
Molecular Formula: C16H20N4O3S
Molecular Weight: 348.42
Percent Composition: C 55.16%, H 5.79%, N 16.08%, O 13.78%, S 9.20%
Literature References: Sulfonylurea loop diuretic. Prepn: J. E. DeLarge et al., DE 2516025; eidem, US 4018929 (1975, 1977 both to A. Christiaens, S.A.); J. DeLarge, C. L. Lapiere, Ann. Pharm. Fr. 36, 369 (1978). Pharmacokinetics in humans: M. Lesne et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 20, 382 (1982). Preliminary evaluation in acute heart failure: R. Stroobandt et al., Arch. Int. Pharmacodyn. 260, 151 (1982). Clinical pharmacology: D. C. Brater et al., Clin. Pharmacol. Ther. 42, 187 (1987). Series of articles on pharmacology, mode of action and renal effects in animals: Arzneim.-Forsch. 35, 1520-1541 (1985); on pharmacology, pharmacokinetics and clinical studies: Eur. J. Clin. Pharmacol. 31, Suppl., 1-55 (1986); Arzneim.-Forsch. 38, 143-214 (1988). Clinical comparison with furosemide, q.v., in congestive heart failure: J. Cosin et al., Eur. J. Heart Fail. 4, 507 (2002).
Properties: mp 163-164°. pKa 6.44.
Melting point: mp 163-164°
pKa: pKa 6.44
Therap-Cat: Diuretic.
Keywords: Diuretic; Sulfonamide Derivatives.