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CAS No 56180-94-0 , acarbose

  • Name: acarbose
  • Synonyms: acarbose;Glucobay;
  • CAS Registry Number:
  • Density: 1.74 g/cm3
  • Refractive index: 1.689
  • Water Solubility: very soluble in water, soluble in methanol, practically insoluble in methylene chloride
  • Safety Statements: Low toxicity by ingestion, subcutaneous, and intravenous routes. Human systemic effects: liver function impaired. When heated to decomposition it emits toxic vapors of NOx.
  • EINECS: 260-030-7
  • Molecular Weight: 645.61
  • InChI: InChI=1/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23u,24-,25-/m1/s1
  • Molecular Formula: C25H43NO18
  • Molecular Structure:CAS No:56180-94-0 acarbose

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56180-94-0 acarbose

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56180-94-0 ACARBOSE

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56180-94-0 O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-a-D-glucopyranosyl-(1-4)-O-a-D-glucopyranosyl-(1-4)-D-Glucose

  • O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-a-D-glucopyranosyl-(1-4)-O-a-D-glucopyranosyl-(1-4)-D-GlucoseAcarbose
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References of acarbose
Title: Acarbose
CAS Registry Number: 56180-94-0
CAS Name: O-4,6-Dideoxy-4-[[[1S-(1a,4a,5b,6a)]-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-a-D-glucopyranosyl-(1?4)-O-a-D-glucopyranosyl-(1?4)-D-glucose
Synonyms: 4￠￠,6￠￠-dideoxy-4￠￠-[(1S)-(1,4,6/5)-4,5,6-trihydroxy-3-hydroxymethyl-2-cyclohexenylamino]maltotriose
Manufacturers' Codes: Bay g 5421
Trademarks: Glucobay (Bayer); Prandase (Bayer); Precose (Bayer)
Molecular Formula: C25H43NO18
Molecular Weight: 645.60
Percent Composition: C 46.51%, H 6.71%, N 2.17%, O 44.61%
Literature References: Pseudotetrasaccharide containing an unsaturated cyclitol moiety. An a-glucosidase inhibitor that reduces sugar absorption in the gastrointestinal tract. Isoln from strains of Actinoplanes: W. Frommer et al., DE 2347782; eidem, US 4062950 (1975, 1977 both to Bayer). Total synthesis: S. Ogawa, Y. Shibata, Chem. Commun. 1988, 605; eidem, Carbohydr. Res. 189, 309 (1989). Biosynthetic studies: U. Degwert et al., J. Antibiot. 40, 855 (1987). Glucosidase inhibition studies: D. D. Schmidt et al., Naturwissenschaften 64, 535 (1977); W. Puls et al., ibid. 536. Use in treatment of diabetic adults: D. Sailor, G. Roder, Arzneim.-Forsch. 30, 2182 (1980); H. Laube et al., ibid. 1154. Long-term study in sulfonylurea-treated diabetics: H. Vierhapper et al., Diabetologia 20, 586 (1981). Potential use in prophylaxis of dental caries: N. E. Fiehn, D. Moe, Scand. J. Dent. Res. 90, 124 (1982). Review of pharmacodynamics, pharmacokinetics and therapeutic potential: S. P. Clissold, C. Edwards, Drugs 35, 214-243 (1988).
Properties: Amorphous powder. [a]D18 +165° (c = 0.4 in water).
Optical Rotation: [a]D18 +165° (c = 0.4 in water)
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; a-Glucosidase Inhibitor.