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CAS No 55837-25-7 , 4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one Search by region : France

  • Name: 4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one
  • Synonyms: Buflomedilum [INN-Latin]; 4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone;55837-25-7;4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one;
  • CAS Registry Number:
  • Flash Point: 228.7°C
  • Boiling Point: 454.5°Cat760mmHg
  • Density: 1.09g/cm3
  • Refractive index: 1.519
  • Safety Statements: 26-36
  • Hazard Symbols: Xn
  • HS Code: 29339990
  • Flash Point: 228.7°C
  • EINECS: 259-851-3
  • Molecular Weight: 307.3847
  • InchiKey: OWYLAEYXIQKAOL-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H25NO4/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-
    8-4-5-9-18/h11-12H,4-10H2,1-3H3
  • Risk Statements: 20/21/22-36/37/38
  • Molecular Formula: C17H25NO4
  • Molecular Structure:CAS No:55837-25-7 4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one

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55837-25-7 BUFLOMEDIL HCL

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References of 4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one
Title: Buflomedil
CAS Registry Number: 55837-25-7
CAS Name: 4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone
Synonyms: 2￠,4￠,6￠-trimethoxy-4-(1-pyrrolidinyl)butyrophenone; (2,4,6-trimethoxyphenyl)-(3-pyrrolidinopropyl) ketone
Molecular Formula: C17H25NO4
Molecular Weight: 307.38
Percent Composition: C 66.43%, H 8.20%, N 4.56%, O 20.82%
Literature References: Prepn: L. Lafon, DE 2122144; idem, US 3895030 (both 1971 to Orsymonde). Pharmacology: J. Duteil et al., Therapie 30, 207 (1975); C. Debray et al., ibid. 259. HPLC determn: J. A. Badmin et al., J. Chromatogr. 172, 319 (1979). Clinical pharmacokinetics: U. Gundert-Remy et al., Eur. J. Clin. Pharmacol. 20, 459 (1981). Comparative safety and efficacy study: G. Rosas et al., Angiology 32, 291 (1981). Review of pharmacology and therapeutic effects: S. P. Clissold et al., Drugs 33, 430-460 (1987).
 
Derivative Type: Hydrochloride
CAS Registry Number: 35543-24-9
Manufacturers' Codes: LL-1656
Trademarks: Bufedil (Abbott); Buflan (Fournier); Buflocit (CT); Buflonat (Nattermann); Fonzylane (Orsymonde); Irrodan (Biomed. Foscama); Lofton (Abbott); Loftyl (Abbott); Provas (Sanol Schwarz)
Molecular Formula: C17H25NO4.HCl
Molecular Weight: 343.85
Percent Composition: C 59.38%, H 7.62%, N 4.07%, O 18.61%, Cl 10.31%
Properties: White crystals from isopropanol, mp 192-193°. LD50 in mice (mg/kg): 80 ±4.6 i.v. (Lafon).
Melting point: mp 192-193°
Toxicity data: LD50 in mice (mg/kg): 80 ±4.6 i.v. (Lafon)
 
Therap-Cat: Vasodilator (peripheral).
Keywords: Vasodilator (Peripheral).