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CAS No 55779-06-1 , Astromicin Search by region : Germany

  • Name: Astromicin
  • Synonyms: fortimicin;Astromicin;
  • CAS Registry Number:
  • Flash Point: 329.4°C
  • Boiling Point: 621.1°Cat760mmHg
  • Density: 1.31g/cm3
  • Safety Statements: Poison by subcutaneous and intravenous routes. Moderately toxic by intraperitoneal and intramuscular routes. Mildly toxic by ingestion. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 329.4°C
  • Molecular Weight: 405.492
  • InChI: InChI=1/C17H35N5O6/c1-7(19)9-5-4-8(20)17(27-9)28-15-11(21)13(24)16(26-3)12(14(15)25)22(2)10(23)6-18/h7-9,11-17,24-25H,4-6,18-21H2,1-3H3/t7-,8+,9-,11-,12-,13-,14+,15+,16+,17+/m0/s1
  • Molecular Formula: C17H35N5O6
  • Molecular Structure:CAS No:55779-06-1 Astromicin

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55779-06-1 Fortimicin

  • Fortimicin
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany null,nullGermany
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References of Astromicin
Title: Fortimicins
Literature References: Aminoglycoside antibiotic complex produced by Micromonospora olivoasterospora. The main components, fortimicins A and B, both exhibit broad-spectrum antibacterial activity. Isoln of A: T. Nara et al., JP Kokai 75 29789 (to Kyowa); eidem, US 3976768 (1976 to Abbott). Isoln of B: eidem, DE 2418349 (1974 to Kyowa); eidem, US 3931400 (1976 to Abbott). Isoln and biological properties of A and B: eidem, J. Antibiot. 30, 533 (1977); physical and chromatographic properties: R. Okachi et al., ibid. 541. Structures of A and B: R. S. Egan et al., ibid. 552. In vitro activity: R. Girolami, J. S. Stamm, ibid. 564. Isoln and properties of minor components, fortimicins C, D, KE: M. Sugimoto et al., ibid. 32, 868 (1979). Synthesis of B: T. Suami, Y. Honda, Chem. Lett. 1980, 641; Y. Honda, T. Suami, Bull. Chem. Soc. Jpn. 55, 1156 (1982).
 
Derivative Type: Fortimicin A
CAS Registry Number: 55779-06-1
CAS Name: 4-Amino-1-[(aminoacetyl)methylamino]-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-b-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositol
Synonyms: astromicin
Manufacturers' Codes: Abbott 44747
Molecular Formula: C17H35N5O6
Molecular Weight: 405.49
Percent Composition: C 50.35%, H 8.70%, N 17.27%, O 23.67%
Properties: White amorphous powder, mp >200° (dec). [a]D25 +87.5° (c = 0.1 in water). Sol in water and lower alcohols. Insol in organic solvents. LD50 (of the sulfate salt) in mice (mg/kg): 380 i.v.; 400 s.c. (Nara, 1977).
Melting point: mp >200° (dec)
Optical Rotation: [a]D25 +87.5° (c = 0.1 in water)
Toxicity data: LD50 (of the sulfate salt) in mice (mg/kg): 380 i.v.; 400 s.c. (Nara, 1977)
 
Derivative Type: Fortimicin B
CAS Registry Number: 54783-95-8
CAS Name: 4-Amino-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-b-L-lyxo-heptopyranosyl)-6-O-methyl-1-(methylamino)-L-chiro-inositol
Molecular Formula: C15H32N4O5
Molecular Weight: 348.44
Percent Composition: C 51.70%, H 9.26%, N 16.08%, O 22.96%
Properties: White amorphous powder, mp 101-103°. [a]D25 +22.2° (c = 0.1 in water). Sol in water and lower alcohols. Insol in organic solvents.
Melting point: mp 101-103°
Optical Rotation: [a]D25 +22.2° (c = 0.1 in water)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Aminoglycosides.