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CAS No 55268-75-2 , Cefuroxime

  • Name: Cefuroxime
  • Synonyms: Cefuroxime acid;Cefuroxime; (6R,7R)-3-[[(Aminocarbonyl)oxy]methyl]-7-[[(2E)-2-(2-furanyl)-2-(methoxyimino)-1-oxoethyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;CEFUROXIME,FREE ACID; Cefuroxime Acid;
  • CAS Registry Number:
  • Melting Point: 171.5-173 ºC
  • Density: 1.76
  • Refractive index: 1.665
  • Safety Statements: Mildly toxic by intravenous route. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.
  • Hazard Symbols: Xn
  • EINECS: 259-560-1
  • Molecular Weight: 424.39
  • InChI: InChI=1/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/b19-9-/t10-,14-/m1/s1
  • Risk Statements: 42/43
  • Molecular Formula: C16H16N4O8S
  • Molecular Structure:CAS No:55268-75-2 Cefuroxime

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References of Cefuroxime
Title: Cefuroxime
CAS Registry Number: 55268-75-2
CAS Name: (6R,7R)-3-[[(Aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-furanyl(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonyms: (6R,7R)-3-carbamoyloxymethyl-7-[2-(2-furyl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-3-carbamoyloxymethyl-7-[2-(2-furyl)-2-(methoxyimino)acetamido]ceph-3-em-4-carboxylic acid
Molecular Formula: C16H16N4O8S
Molecular Weight: 424.39
Percent Composition: C 45.28%, H 3.80%, N 13.20%, O 30.16%, S 7.56%
Literature References: Prepn: M. C. Cook et al., DE 2439880; eidem, US 3974153 (1973, 1976 both to Glaxo). Prepn of the 1-acetoxyethyl ester: M. Gregson, B. Sykes, DE 2706413; eidem, US 4267320 (1977, 1981 both to Glaxo). In vitro studies: C. H. O'Callaghan et al., Antimicrob. Agents Chemother. 9, 511 (1976); R. N. Jones et al., ibid. 12, 47 (1977). In vitro antibacterial activity, human pharmacokinetics: C. H. O'Callaghan et al., J. Antibiot. 29, 29 (1976). Pharmacology: H. Freiesleben et al., Proc. 10th Int. Congr. Chemother., Zürich, 1977 (Am. Soc. for Microbiol., Washington, 1978) II, pp 873-874. Pharmacokinetics: P. E. Gower, ibid. 877-878; J. Kosmidis et al., ibid. 875-876. Clinical studies: P. F. Wood et al., ibid. 1042-1044; R. Norrby et al., J. Antimicrob. Chemother. 3, 355 (1977). Review of antibacterial activity, pharmacology and therapeutic efficacy: R. N. Brogden et al., Drugs 17, 233-266 (1979). Comprehensive description: T. J. Wozniak, J. R. Hicks, Anal. Profiles Drug Subs. 20, 209-236 (1991).
Properties: White crystalline solid. [a]D20 +63.7° (c = 1.0 in 0.2M pH 7 phosphate buffer). uv max (pH 6 phosphate buffer): 274 nm (e 17600).
Optical Rotation: [a]D20 +63.7° (c = 1.0 in 0.2M pH 7 phosphate buffer)
Absorption maximum: uv max (pH 6 phosphate buffer): 274 nm (e 17600)
 
Derivative Type: Sodium salt
CAS Registry Number: 56238-63-2
Trademarks: Anaptivan (Help); Biociclin (Del Saz & Filippini); Biofurex (Lenza); Bioxima (Ital. Suisse); Cefamar (Firma); Cefoprim (Esseti); Cefumax (Locatelli); Cefurex (Sarm); Cefurin (Magis); Curocef (GSK); Curoxim (Elan); Duxima (Dukron); Gibicef (Metapharma); Ipacef (IPA); Kefurox (Lilly); Kesint (Proter); Lampsporin (Von Boch); Medoxim (Medici); Novocef (Pliva); Spectrazole (Mallinckrodt); Ultroxim (Duncan Flockhart); Zinacef (GSK)
Molecular Formula: C16H15N4NaO8S
Molecular Weight: 446.37
Percent Composition: C 43.05%, H 3.39%, N 12.55%, Na 5.15%, O 28.67%, S 7.18%
Properties: White solid. [a]D20 +60° (c = 0.91 in water). uv max (water): 274 nm (e 17400). Freely sol in water and buffered solutions; sol in methanol; very slightly sol in ethyl acetate, diethyl ether, octanol, benzene and chloroform. Soly in water: 500 mg/2.5 ml. pKa (water): 2.5; (DMF): 5.1. Solns are stable at room temp for 13 hrs; <10% decompn in 48 hrs at 25° (O'Callaghan, J. Antibiot.).
pKa: pKa (water): 2.5; (DMF): 5.1
Optical Rotation: [a]D20 +60° (c = 0.91 in water)
Absorption maximum: uv max (water): 274 nm (e 17400)
 
Derivative Type: 1-Acetoxyethyl ester
Synonyms: Cefuroxime axetil
Manufacturers' Codes: CCI-15641
Trademarks: Ceftin (GSK); Cefurax (Betapharm); Cepazine (Sanofi-Synthelabo); Elobact (Cascan); Oraxim (Menarini); Zinat (GSK); Zinnat (GSK)
Molecular Formula: C20H22N4O10S
Molecular Weight: 510.47
Percent Composition: C 47.06%, H 4.34%, N 10.98%, O 31.34%, S 6.28%
 
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.