Title: Flecainide
CAS Registry Number: 54143-55-4
CAS Name: N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
Molecular Formula: C17H20F6N2O3
Molecular Weight: 414.34
Percent Composition: C 49.28%, H 4.87%, F 27.51%, N 6.76%, O 11.58%
Literature References: Prepn: E. H. Banitt, W. R. Brown,
US 3900481 (1975 to Riker); of the acetate:
eidem, US 4005209 (1977 to Riker); E. H. Banitt
et al., J. Med. Chem. 20, 821 (1977). Preliminary pharmacological study: J. R. Schmid
et al., Fed. Proc. 34, 775 (1975).
In vitro electrophysiological study: A. B. Hodess
et al., J. Cardiovasc. Pharmacol. 1, 427 (1979). Antiarrhythmic effects: P. Somani,
Clin. Pharmacol. Ther. 27, 464 (1980). Use in acute exptl myocardial infarction: H. Gülker
et al., Z. Cardiol. 70, 124 (1981). Clinical study in ventricular arrhythmias: J. L. Anderson
et al., N. Engl. J. Med. 305, 473 (1981). Determn of acetate in human plasma by spectrophotofluorometry: S. F. Chang
et al., Arzneim.-Forsch. 33, 251 (1983). Review of pharmacology and clinical efficacy: D. M. Roden, R. L. Woosley,
N. Engl. J. Med. 315, 36-41 (1986). Symposium on clinical experience:
Am. J. Cardiol. 62, Suppl., 1D-67D (1988). Comprehensive description: S. Alessi-Severini
et al., Anal. Profiles Drug Subs. Excip. 21, 169-195 (1992).
Properties: uv max (ethanol): 205, 230, 300 nm (E1%1cm 521, 219, 59).
Absorption maximum: uv max (ethanol): 205, 230, 300 nm (E1%1cm 521, 219, 59)
Derivative Type: Monoacetate
CAS Registry Number: 54143-56-5
Manufacturers' Codes: R-818
Trademarks: Almarytm (Synthelabo); Apocard (Esteve); Ecrinal (Pharma Investi); Flécaine (3M Pharma); Tambocor (3M Pharma)
Molecular Formula: C17H20F6N2O3.C2H4O2
Molecular Weight: 474.39
Percent Composition: C 48.10%, H 5.10%, F 24.03%, N 5.91%, O 16.86%
Properties: White granular solid from isopropyl alcohol/isopropyl ether, mp 145-147°. Soly at 37° (mg/ml): water 48.4, alcohol 300.
Melting point: mp 145-147°
Therap-Cat: Antiarrhythmic (class IC).
Keywords: Antiarrhythmic.
