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CAS No 54-80-8 , 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol

  • Name: 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol
  • Synonyms: 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol; NETH; Nethalide; Inetol; Alderlin; Naphthylisoproterenol; Pronetalolo [DCIT]; Neathalide; ( -)-Pronethalol;Pronetalol;
  • CAS Registry Number:
  • Flash Point: 84.3°C
  • Boiling Point: 322.4°Cat760mmHg
  • Density: 1.074g/cm3
  • Safety Statements: Poison by ingestion, intravenous, and intraperitoneal routes. Questionable carcinogen with experimental carcinogenic and tumorigenic data. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 84.3°C
  • Molecular Weight: 229.31746
  • InchiKey: HRSANNODOVBCST-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H19NO/c1-11(2)16-10-15(17)14-8-7-12-5-3-4-6-13(12)9-14/h3-9,
    11,15-17H,10H2,1-2H3
  • Molecular Formula: C15H19NO
  • Molecular Structure:CAS No:54-80-8 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol

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References of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol
Title: Pronethalol
CAS Registry Number: 54-80-8
CAS Name: a-[[(1-Methylethyl)amino]methyl]-2-naphthalenemethanol
Synonyms: a-[(isopropylamino)methyl]-2-naphthalenemethanol; [2-hydroxy-2-(2-naphthyl)ethyl]isopropylamine; 2-isopropylamino-1-(2-naphthyl)ethanol; 1-(2￠-naphthyl)-2-isopropylaminoethanol; nethalide
Molecular Formula: C15H19NO
Molecular Weight: 229.32
Percent Composition: C 78.56%, H 8.35%, N 6.11%, O 6.98%
Literature References: b-Adrenergic blocker. Prepd by reduction of 2-naphthacyl bromide with NaBH4 followed by reaction with isopropylamine: Stephenson, GB 909357 (1962 to ICI). Pharmacology: Black et al., Br. J. Pharmacol. Chemother. 25, 577 (1965). Carcinogenicity in mice: R. Howe, Nature 207, 594 (1965). Metabolism: W. G. Stillwell, M. G. Horning, Res. Commun. Chem. Pathol. Pharmacol. 9, 601 (1974).
Properties: Crystals, mp 108°.
Melting point: mp 108°
 
Derivative Type: Hydrochloride
CAS Registry Number: 51-02-5
Manufacturers' Codes: ICI-38174
Trademarks: Alderlin (Zeneca)
Molecular Formula: C15H19NO.HCl
Molecular Weight: 265.78
Percent Composition: C 67.79%, H 7.58%, N 5.27%, O 6.02%, Cl 13.34%
Properties: Crystals, mp 184°. LD50 in mice (mg/kg): 512 orally, 46 i.v. (Black).
Melting point: mp 184°
Toxicity data: LD50 in mice (mg/kg): 512 orally, 46 i.v. (Black)
 
Therap-Cat: Antianginal; antiarrhythmic; antihypertensive.
Keywords: ?Adrenergic Blocker; Antianginal; Antiarrhythmic; Antihypertensive; Arylethanolamine Derivatives.