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CAS No 53714-56-0 , Leuprorelin

  • Name: Leuprorelin
  • Synonyms: A43818;PGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHC2H5;(D-Leu6,des-Gly-NH210)-LH-RH ethylamide;Lupron SR;D-Leu6-des-Gly10-LH-releasing hormone ethylamide;NSC 377526;1: PN: WO02087616 PAGE: 31 claimed protein;Leuprorelin;Des-Gly10-[D-Leu6]-LH-releasing hormone ethylamide;Luteinizinghormone-releasing factor (pig),6-D-leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide-;Leuprolide Acetate;1-9-Luteinizinghormone-releasing factor (swine), 6-D-leucine-9-(N-ethyl-L-prolinamide)-;Des-Gly10-[D-Leu6]LH-RHethylamide;
  • CAS Registry Number:
  • Density: 1.44 g/cm3
  • Refractive index: 1.681
  • Safety Statements: 22-24/25
  • Molecular Weight: 1209.41
  • InChI: InChI=1/C59H84N16O12/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64)/t40-,41-,42-,43+,44-,45-,46-,47-,48-/m0/s1
  • Molecular Formula: C59H84N16O12
  • Molecular Structure:CAS No:53714-56-0 Leuprorelin

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    References of Leuprorelin
    Title: Leuprolide
    CAS Registry Number: 53714-56-0
    CAS Name: 6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamideluteinizing hormone-releasing factor (pig)
    Synonyms: leuprorelin; (D-Leu6)-des-Gly10-LH-RH-ethylamide
    Molecular Formula: C59H84N16O12
    Molecular Weight: 1209.40
    Percent Composition: C 58.59%, H 7.00%, N 18.53%, O 15.88%
    Literature References: Synthetic nonapeptide agonist analog of LH-RH, q.v. Prepn: M. Fujino et al., DE 2446005 (1975 to Takeda), C.A. 83, 10895y (1975); R. L. Gendrich et al., US 4005063 (1977 to Abbott). Synthesis: J. A. Vilchez-Martinez et al., Biochem. Biophys. Res. Commun. 59, 1226 (1974); M. Fujino et al., ibid. 60, 406 (1974). Comparison of biological activity with natural LH-RH: D. H. Coy et al., ibid. 67, 576 (1975). Pharmacokinetics: L. T. Sennello et al., J. Pharm. Sci. 75, 158 (1986). Clinical efficacy in prostatic carcinoma: M. B. Garnick et al., N. Engl. J. Med. 311, 1281 (1984); in benign prostatic hypertrophy: L. M. Eri, K. J. Tveter, J. Urol. 150, 359 (1993). Clinical trial in endometriosis: J. M. Wheeler et al., Am. J. Obstet. Gynecol. 167, 1367 (1992).
    Properties: Fluffy solid. [a]D25 -31.7° (c = 1 in 1% acetic acid).
    Optical Rotation: [a]D25 -31.7° (c = 1 in 1% acetic acid)
     
    Derivative Type: Monoacetate (salt)
    CAS Registry Number: 74381-53-6
    Synonyms: Leuprolide acetate
    Manufacturers' Codes: Abbott 43818; A-43818; TAP-144
    Trademarks: Carcinil (Abbott); Eligard (Sanofi-Aventis); Enantone (Takeda); Leuplin (Takeda); Lucrin (Abbott); Lupron (TAP); Prostap (Wyeth); Viadur (Alza)
    Molecular Formula: C59H84N16O12.C2H4O2
    Molecular Weight: 1269.45
    Percent Composition: C 57.71%, H 6.99%, N 17.65%, O 17.64%
     
    Therap-Cat: Antineoplastic (hormonal); LH-RH agonist.
    Keywords: Antineoplastic (Hormonal); LH-RH Analogs; LH-RH Agonist.