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CAS No 53643-48-4 , Vindesine

  • Name: Vindesine
  • Synonyms: DAVA; Vindesinum [INN-Latin]; Vindesina; Lilly 112531;Desacetylvinblastine amide;Vindesine; Vindesinum; Vindesina [INN-Spanish]; Eldesine; Vindesin;
  • CAS Registry Number:
  • Transport: 1544
  • Melting Point: 230-232 deg C
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.41g/cm3
  • Refractive index: 1.707
  • Safety Statements: Mutation data reported. When heated to decomposition it emits toxic vapors of NOx.
  • Flash Point: °C
  • EINECS: 258-682-2
  • Molecular Weight: 753.9261
  • InchiKey: HHJUWIANJFBDHT-KOTLKJBCSA-N
  • InChI: InChI=1S/C43H55N5O7/c1-6-39(52)21-25-22-42(38(51)55-5,
    33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32
    (29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,
    53)37(44)50/h8-12,14,19-20,25,34-36,45,49,52-53H,6-7,13,15-18,21-24H2,
    1-5H3,(H2,44,50)/t25-,34+,35-,36-,39+,40-,41-,42+,43+/m1/s1
  • Molecular Formula: C43H55N5O7
  • Molecular Structure:CAS No:53643-48-4 Vindesine

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53643-48-4 DESACETYLVINBLASTINEAMIDE

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
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53643-48-4 VINDESINE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
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53643-48-4 Vindesine

  • China Kouting Chemical Co.,Ltd [Importer/Exporter]
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  • Address: Hunan Road, Pudong New District, Shanghai, Shanghai 201318, shanghai,shanghaiChina
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53643-48-4 Vincaleukoblastine,3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)-

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53643-48-4 Vindesine

  • Vindesine 53643-48-4 C43H55N5O7 753.93 ??5%
  • China shanghai Tauto Biotech Co., Ltd [Manufacturer]
  • Tel: +86-21-51320588
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  • Address: No. 326, Aidisheng Rd , Zhangjiang Hi-tech Park, Shanghai , P.R.CHINA Shanghai,ShanghaiChina
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53643-48-4 VINDESINE

  • China IFFECT CHEMPHAR CO., LTD. null
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53643-48-4 Vindesine

  • China Lightchem Limited [Manufacturers]
  • Tel: +86-(571)-85983207, 56330213
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  • Address: Room 417, Liangyou Building, No. 64 Xinshi Street, Hangzhou, Zhejiang 310014, null,ZhejiangChina
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References of Vindesine
Title: Vindesine
CAS Registry Number: 53643-48-4
CAS Name: 3-(Aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine
Synonyms: desacetylvinblastine amide; VDS
Manufacturers' Codes: Compound 112531; NSC-245467
Molecular Formula: C43H55N5O7
Molecular Weight: 753.93
Percent Composition: C 68.50%, H 7.35%, N 9.29%, O 14.85%
Literature References: Synthetic deriv of the dimeric Catharanthus alkaloid vinblastine, q.v. Prepn: G. J. Cullinan, K. Gerzon, DE 2415980 (1974 to Lilly), C.A. 82, 72191r (1975); see also C. J. Burnett et al., J. Med. Chem. 21, 88 (1978). 13C-NMR spectroscopy: D. E. Dorman, J. W. Paschal, Org. Magn. Reson. 8, 413 (1976). Antitumor activity in rodents: M. J. Sweeney et al., Cancer Res. 38, 2886 (1978). Pharmacokinetics: R. J. Owellen et al., ibid. 37, 2603 (1977). Use in acute lymphocytic leukemia of childhood: W. Krivit et al., Cancer Chemother. Pharmacol. 2, 267 (1979). Brief review of preclinical and early clinical data: R. W. Dyke et al., ibid. 229. Toxicology: G. C. Todd et al., Toxicol. Environ. Health 1, 843 (1976); R. J. Owellen et al., Biochem. Pharmacol. 26, 1213 (1977).
Properties: Crystals from ethanol-methanol, mp 230-232°. [a]D25 +39.4° (c = 1.0 in methanol). uv max (methanol): 214, 266, 288, 296 nm (e 53400, 17450, 13950, 12500). pKa￠ (DMF 66%) 5.39, 7.36; (H2O) 6.04, 7.67.
Melting point: mp 230-232°
pKa: pKa￠ (DMF 66%) 5.39, 7.36; (H2O) 6.04, 7.67
Optical Rotation: [a]D25 +39.4° (c = 1.0 in methanol)
Absorption maximum: uv max (methanol): 214, 266, 288, 296 nm (e 53400, 17450, 13950, 12500)
 
Derivative Type: Sulfate salt
CAS Registry Number: 59917-39-4
Manufacturers' Codes: LY-099094
Trademarks: Eldisine (Lilly); Fildesin (Shionogi)
Molecular Formula: C43H55N5O7.H2SO4
Molecular Weight: 852.00
Percent Composition: C 60.62%, H 6.74%, N 8.22%, O 20.66%, S 3.76%
Properties: Amorphous solid from ethanol-isopropyl alcohol, mp >250° (solvated form). LD50 in mice, rats (mg/kg): 6.3 ± 0.6, 2.0 ± 0.2 i.v. (Todd); in mice: 8.8 ± 2.5 i.p. (Owellen, Biochem. Pharmacol.).
Melting point: mp >250° (solvated form)
Toxicity data: LD50 in mice, rats (mg/kg): 6.3 ± 0.6, 2.0 ± 0.2 i.v. (Todd); in mice: 8.8 ± 2.5 i.p. (Owellen, Biochem. Pharmacol.)
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkaloids/Natural Products; Vinca Alkaloids.