Home > Name List By 4 > 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2, 2-diphenylbutanamide

CAS No 53179-11-6 , 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,
2-diphenylbutanamide

  • Name: 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,
    2-diphenylbutanamide
  • Synonyms: Loperamidum [INN-Latin]; Rho-Loperamide; Apo-Loperamide;4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,
    2-diphenylbutanamide; Nu-Loperamide;Ioperamide; Kaopectate II; Loperacap; PMS-Loperamide;
  • CAS Registry Number:
  • Density: 1.187g/cm3
  • Refractive index: 1.6
  • EINECS: 258-416-5
  • Molecular Weight: 477.03752
  • InchiKey: RDOIQAHITMMDAJ-UHFFFAOYSA-N
  • InChI: InChI=1S/C29H33ClN2O2/c1-31(2)27(33)29(24-9-5-3-6-10-24,
    25-11-7-4-8-12-25)19-22-32-20-17-28(34,
    18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3
  • Molecular Formula: C29H33ClN2O2
  • Molecular Structure:CAS No:53179-11-6 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,<br />2-diphenylbutanamide
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53179-11-6 1-Piperidinebutanamide,4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-

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53179-11-6 1-Piperidinebutanamide,4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-

  • China YiPeng Chemical [Manufacturers]
  • Tel: 571 85376369
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  • Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China ,ZheJiangChina
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53179-11-6 Loperamide

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
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  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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53179-11-6 Loperamide

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53179-11-6 LOPERAMIDE

  • India JAI RADHE SALES []
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  • Address: 309/310 HARIKRUPA TOWER,NR.OLD SHARDA MANDIR CHAR RASTA,ELLISBRIDGE ,AHMEDABAD,GUJRAT , INDIA. ,India
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53179-11-6 Loperamide

  • India Shreeji Pharma International [Manufacturers]
  • Tel: +91-265-3019110
  • Fax: +91-265-2465036
  • Address: FF/10, Narsinghdham Complex, Sangam Chararasta, Harni Road, Vadodara, Gujarat 390018, Vadodara,GujaratIndia
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53179-11-6 Loperamide

  • United States CBSCHEM LIMITED []
  • Fax: (888) 557-9843
  • Address: 621 South 48th Street, Suite 115,Tempe, AZ 85281 ,United States
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53179-11-6 Loperamide

  • Hong kong LEO CHEMICAL (HONG KONG) CO., LTD [Manufacturer]
  • Tel: 86-519-85098858/ 86-519-85098877
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53179-11-6 LOPERAMIDE

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53179-11-6 Loperamide

  • Hong kong Leawell International Limited [Importer/Exporter]
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References of 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,
2-diphenylbutanamide
Title: Loperamide
CAS Registry Number: 53179-11-6
CAS Name: 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidinebutanamide
Synonyms: 4-(p-chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidinebutyramide
Molecular Formula: C29H33ClN2O2
Molecular Weight: 477.04
Percent Composition: C 73.01%, H 6.97%, Cl 7.43%, N 5.87%, O 6.71%
Literature References: Prepn: Janssen et al., FR 2100711; eidem, US 3714159 (1972, 1973 to Janssen); Stokbroekx et al., J. Med. Chem. 16, 782 (1973). LC-MS/MS determn in plasma: B. Streel et al., J. Chromatogr. B 814, 263 (2005). Series of articles on pharmacology, toxicology, metabolism, and clinical studies: Arzneim.-Forsch. 24, 1640-1665 (1974). Toxicity studies: C. J. E. Niemegeers et al., ibid. 1633, 1636. Review: D. A. Shriver et al., in Pharmacological and Biochemical Properties of Drug Substances vol. 3, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1981) pp 461-476. Comprehensive description: J. Van Rompay, J. E. Carter, Anal. Profiles Drug Subs. 19, 341-365 (1990).
 
Derivative Type: Hydrochloride
CAS Registry Number: 34552-83-5
Manufacturers' Codes: PJ-185; R-18553
Trademarks: Arret (Janssen); Blox (Biomed. Foscama); Brek (Irbi); Dissenten (SPA); Fortasec (Esteve); Imodium (Janssen); Imosec (Janssen); Imossel (Janssen-Solucal); Lopemid (Gentili); Lopemin (Dainippon); Loperyl (Zambeletti); Suprasec (J & J); Tebloc (Dukron)
Molecular Formula: C29H33ClN2O2.HCl
Molecular Weight: 513.50
Percent Composition: C 67.83%, H 6.67%, Cl 13.81%, N 5.46%, O 6.23%
Properties: Crystals from isopropanol, mp 222-223°. uv max (0.1N HCl/2-propanol, 10/90 v/v): 253, 259, 265, 273 nm (e 532, 648, 581, 233). Soly (g/100ml): water (pH 1.7) 0.14; citrate-phosphate (pH 6.1) 0.008; citrate-phosphate (pH 7.9) <0.001; methanol 28.6; ethanol 5.37; 2-propanol 1.11; dichloromethane 35.1; acetone 0.20; ethyl acetate 0.035; diethyl ether <0.001; hexane <0.001; toluene 0.001; N,N-dimethylformamide 10.3; tetrahydrofuran 0.32; 4-methyl-2-pentanone 0.020; propylene glycol 5.64; polyethylene glycol 400 1.40; dimethylsulfoxide 20.5; 2-butanone 0.18. pKa 8.66. Practically insol in H2O at physiological pH (0.002%). Stable, can be stored for several years under normal conditions; not hygroscopic; not affected by light. LD50 in mice (mg/kg): 75 s.c.; 28 i.p.; 105 orally; in rats (mg/kg): 185 orally (Niemegeers).
Melting point: mp 222-223°
pKa: pKa 8.66
Absorption maximum: uv max (0.1N HCl/2-propanol, 10/90 v/v): 253, 259, 265, 273 nm (e 532, 648, 581, 233)
Toxicity data: LD50 in mice (mg/kg): 75 s.c.; 28 i.p.; 105 orally; in rats (mg/kg): 185 orally (Niemegeers)
 
Therap-Cat: Antidiarrheal.
Keywords: Antidiarrheal.