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CAS No 53123-88-9 , Rapamycin

  • Name: Rapamycin
  • Synonyms: Sirolimus;sirolimus;23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine; Rapamycin;Rapamycin;
  • CAS Registry Number:
  • Flash Point: 542.261 ºC
  • Boiling Point: 973.017 ºC at 760 mmHg
  • Density: 1.182 g/cm3
  • Refractive index: 1.55
  • Water Solubility: Soluble in DMSO and Methanol
  • Safety Statements: Poison by intraperitoneal route. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
  • Hazard Symbols: Xi: Irritant;
  • Flash Point: 542.261 ºC
  • Molecular Weight: 914.18
  • InChI: InChI=1/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37?,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
  • Risk Statements: S22;S24/25
  • Molecular Formula: C51H79NO13
  • Molecular Structure:CAS No:53123-88-9 Rapamycin
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53123-88-9 Rapamycin

  • Rapamycin is a macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. https://www.creative-peptides.com/product/rapamycin-item-...
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  • United States Creative Peptides [Manufacturer]
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  • Fax: 1-631-6147828
  • Address: 45-16 Ramsey Road Shirley New York,New YorkUnited States
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53123-88-9 Rapamycin

  • Rapamycin Synonyms:23,27-epoxy-3h-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine;Nsc-226080;Rapa;Rapamune;Rapamycin;Rapamycin, streptomyces hygroscopicus;Rpm Cas:53123-88-9 Mf:C51h79no13 Mw:914.18 Einecs:262-640-9 Product categories:Active pharmaceutica...
  • Min. Order: 100000
  • FOB Price: USDfalse - false /
  • China Hubei Yuancheng Saichuang Technology Co.,Ltd. [Manufacturer]
  • Tel: 86-27-50756228
  • Fax: 86-27-88048077
  • Address: Wuchang wuhan,HubeiChina
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53123-88-9 Sirolimus

  • Tasteless, white to white crystalline powder 99% min
  • China Hangzhou Dingyan Chem Co.,Ltd [Manufacturer, Trading Company, Distributor/Wholesaler]
  • Tel: 86-571-88025800
  • Fax: 86-571-87156470
  • Address: Xiasha 571, 19TH Street E-COMMERCE 4A 601-602 , Jianggan Area hangzhou,ZhejiangChina

53123-88-9 rapamycin from streptomyces*hygroscopicus

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53123-88-9 rapamycin from streptomyces*hygroscopicus

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi ,ShanXiChina
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53123-88-9 Rapamycin

  • we can offer bulk pharmaceutical Rapamycin CAS NO.53123-88-9 which used as immunosuppressive agent. I also enclose you our product list as below and pls feel free to contact us for your any demands Naftopidil CAS no.57149-07-2, Rosiglitazone maleate ...
  • China Chengdu Yuyang High-Tech Development Co.,Ltd [Manufacturer]
  • Tel: 86-28-61777709
  • Address: No,88,West Guoning Road Chengdu,SichuanChina
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53123-88-9 rapamycin from streptomyces*hygroscopicus

  • United States Ivy Fine Chemicals [Manufacturer]
  • Tel: 856-465-8550
  • Fax: 856-616-1161
  • Address: Ivy Fine Chemicals
    1312 Bunker Hill Drive
    Cherry Hill, NJ 08003
    USA ,United States
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53123-88-9 rapamycin from streptomyces*hygroscopicus

  • China YiPeng Chemical [Manufacturers]
  • Tel: 571 85376369
  • Fax: 571 88233092
  • Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China ,ZheJiangChina
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53123-88-9 rapamycin from streptomyces*hygroscopicus

  • China Boronsyn Co.,Ltd [Manufacturer]
  • Tel: +86-21-58407925
  • Fax: +86-21-58408291
  • Address: 1213 JunMin Road,Pudong,China ,China
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53123-88-9 rapamycin from streptomyces*hygroscopicus

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References of Rapamycin
Title: Rapamycin
CAS Registry Number: 53123-88-9
Synonyms: Sirolimus; RAPA; RPM
Manufacturers' Codes: AY-22989; NSC-226080
Trademarks: Rapamune (Wyeth)
Molecular Formula: C51H79NO13
Molecular Weight: 914.17
Percent Composition: C 67.01%, H 8.71%, N 1.53%, O 22.75%
Literature References: Triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa Nui. Isoln: S. N. Sehgal et al., DE 2347682; eidem, US 3929992 (1974, 1975 both to Ayerst McKenna Harrison); purification and characterization: C. Vézina et al., J. Antibiot. 28, 721 (1975); S. N. Sehgal et al., ibid. 727. Inhibition of immune response: R. R. Martel et al., Can. J. Physiol. Pharmacol. 55, 48 (1977); of graft rejection in mice: C. P. Eng et al., Transplant. Proc. 23, 868 (1991). Total synthesis: K. C. Nicolaou et al., J. Am. Chem. Soc. 115, 4419 (1993); D. Romo et al., ibid. 7906. Series of articles on therapeutic monitoring and pharmacokinetics: Clin. Ther. 22, Suppl. 2, B1-B132 (2000); on pharmacology and clinical experience in transplantation: Transplant. Proc. 35, Suppl. 1, S1-S233 (2003). Clinical trial in prevention of coronary restenosis: D. R. Holmes, Jr. et al., Circulation 109, 634 (2004).
Properties: Colorless crystalline solid from ether, mp 183-185°. uv max (95% ethanol): 267, 277, 288 nm (E1%1cm 417, 541, 416). [a]D25 -58.2° (methanol). Sol in ether, chloroform, acetone, methanol and DMF; very sparingly sol in hexane and petr ether. Substantially insol in water. LD50 in mice (mg/kg): ?600 i.p.; >2,500 orally (Vézina).
Melting point: mp 183-185°
Optical Rotation: [a]D25 -58.2° (methanol)
Absorption maximum: uv max (95% ethanol): 267, 277, 288 nm (E1%1cm 417, 541, 416)
Toxicity data: LD50 in mice (mg/kg): ?600 i.p.; >2,500 orally (Vézina)
Use: Tool for immunochemistry.
Therap-Cat: Immunosuppressant; antirestenotic.
Keywords: Immunosuppressant; Antirestenotic.