Title: Norelgestromin
CAS Registry Number: 53016-31-2
CAS Name: (17a)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one oxime
Synonyms: 17-deacetylnorgestimate; 18-methylnorethindrone oxime; levonorgestrel 3-oxime
Manufacturers' Codes: RWJ-10553
Molecular Formula: C21H29NO2
Molecular Weight: 327.46
Percent Composition: C 77.02%, H 8.93%, N 4.28%, O 9.77%
Literature References: Bioactive metabolite of norgestimate,
q.v. Prepd as intermediate of norgestrel,
q.v.:
NL 7306609 (1973 to Richter Gedeon). Prepn and identification as norgestimate metabolite: S. F. Sisenwine
et al., Contraception 15, 25 (1977). Pharmacology: J. L. McGuire
et al., Am. J. Obstet. Gynecol. 163, 2127 (1990). Use as contraceptive patch: J. Jona
et al., WO 9640355;
eidem,
US 5876746 (1996, 1999 both to Cygnus). Clinical pharmacokinetics: L. S. Abrams
et al., Br. J. Clin. Pharmacol. 53, 141 (2002). Review of clinical pharmacology and efficacy: R. T. Burkman,
Int. J. Fertil. 47, 69-76 (2002); B. L. Sicat,
Pharmacotherapy 23, 472-480 (2003).
Properties: Crystals, mp 112°.
Melting point: mp 112°
Derivative Type: Combination with ethinyl estradiol
CAS Registry Number: 396715-57-4
Trademarks: Evra (Janssen-Cilag); Ortho Evra (Ortho)
Therap-Cat: Progestogen; in combination with estrogen as transdermal contraceptive.
Keywords: Progestogen; Contraceptive (Transdermal).