Home > Name List By 2 > 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-1,2, 4-triazol-3-one

CAS No 52942-31-1 , 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-1,2,
4-triazol-3-one

  • Name: 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-1,2,
    4-triazol-3-one
  • Synonyms: SureCN49314; Etoperidonum [INN-Latin]; Etoperidone [INN]; Etoperidonum; Etoperidona [Spanish]; Etoperidona;52942-31-1; UNII-KAI6MVO39Z;2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-1,2,
    4-triazol-3-one;
  • CAS Registry Number:
  • Flash Point: 255.6°C
  • Boiling Point: 499°Cat760mmHg
  • Density: 1.23g/cm3
  • Refractive index: 1.613
  • Flash Point: 255.6°C
  • EINECS: 260-942-5
  • Molecular Weight: 377.91152
  • InchiKey: IZBNNCFOBMGTQX-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H28ClN5O/c1-3-18-21-25(19(26)24(18)4-2)10-6-9-22-11-13-23
    (14-12-22)17-8-5-7-16(20)15-17/h5,7-8,15H,3-4,6,9-14H2,1-2H3
  • Molecular Formula: C19H28ClN5O
  • Molecular Structure:CAS No:52942-31-1 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-1,2,<br />4-triazol-3-one

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References of 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-1,2,
4-triazol-3-one
Title: Etoperidone
CAS Registry Number: 52942-31-1
CAS Name: 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one
Molecular Formula: C19H28ClN5O
Molecular Weight: 377.91
Percent Composition: C 60.39%, H 7.47%, Cl 9.38%, N 18.53%, O 4.23%
Literature References: Psychotropic drug related structurally to trazodone, q.v. Prepn: G. Palazzo, DE 2351739; idem, US 3857845 (both 1974 to Angelini). Pharmacology and acute toxicity: R. Lisciani et al., Arzneim.-Forsch. 28, 417 (1978); M. T. Ramacci et al., ibid. 29, 294 (1979). Clinical evaluation: P. Bertoletti, G. Clin. Med. 58, 393 (1977). Teratology study: S. Barcellona et al., Toxicology 8, 87 (1977). Acute cardiovascular toxicity study: R. Lisciani et al., ibid. 10, 151 (1978).
Properties: Liq, bp0.5 230°.
Boiling point: bp0.5 230°
 
Derivative Type: Hydrochloride
CAS Registry Number: 57775-22-1
Manufacturers' Codes: AF-1191; ST-1191
Trademarks: Axiomin (Promeco); Depracer (Lepori); Etoran (Il Dong); Staff (Sigma-Tau); Tropene (Degussa)
Molecular Formula: C19H28ClN5O.HCl
Molecular Weight: 414.37
Percent Composition: C 55.07%, H 7.05%, Cl 17.11%, N 16.90%, O 3.86%
Properties: Crystals from isopropanol, mp 197-198°. pH (2% aq soln): 4.1 ± 0.2. Sol in water, alc; slightly sol in chloroform. Practically insol in acetone, benzene, ether. LD50 in mice, rats (mg/kg): 580, 720 orally; 72, 62 i.v.; 135, 120 i.p. (Lisciani).
Melting point: mp 197-198°
Toxicity data: LD50 in mice, rats (mg/kg): 580, 720 orally; 72, 62 i.v.; 135, 120 i.p. (Lisciani)
 
Therap-Cat: Antidepressant.
Keywords: Antidepressant.