Title: Magnolol
CAS Registry Number: 528-43-8
CAS Name: 5,5￠-Di-2-propenyl-[1,1￠-biphenyl]-2,2￠-diol
Synonyms: 5,5￠-diallyl-2,2￠-biphenyldiol; 2,2￠-bichavicol; dehydrodichavicol; 2,2￠-dihydroxy-5,5￠-diallylbiphenyl
Molecular Formula: C18H18O2
Molecular Weight: 266.33
Percent Composition: C 81.17%, H 6.81%, O 12.01%
Literature References: Bioactive constituent of
Magnoliae Cortex, the bark of
Magnolia officinalis, Rehd. et Wils.,
Magnoliaceae, known in Chinese traditional medicine as
houpo, or of
M. obovata, Thunb., called
wakoboku in Japanese. Isoln: Y. Sugii,
Yakugaku Zasshi 50, 183 (1930),
C.A. 24, 3505 (1930). Synthesis: H. Erdtman, J. Runeberg,
Acta Chem. Scand. 11, 1060 (1957); J. Runeberg,
ibid. 12, 188 (1958). Isoln from seeds of
M. grandiflora L.: F. S. El-Feraly, W.-S. Li,
Lloydia 41, 442 (1978). CNS depressant effects: K. Watanabe
et al., Jpn. J. Pharmacol. 25, 605 (1975);
eidem, Planta Med. 49, 103 (1983). Anti-inflammatory and analgesic effects: J.-P. Wang
et al., Arch. Pharmacol. 346, 707 (1992). HPLC determn: T.-H. Tsai, C.-F. Chen,
J. Chromatogr. 598, 143 (1992).
Properties: mp 101.5-102°. uv max: 293 nm (log e 3.90). Sol in ethanol.
Melting point: mp 101.5-102°
Absorption maximum: uv max: 293 nm (log e 3.90)
