Title: Honokiol
CAS Registry Number: 35354-74-6
CAS Name: 3￠,5-Di-2-propenyl-[1,1￠-biphenyl]-2,4￠-diol
Synonyms: 3￠,5-diallyl-2,4￠-biphenyldiol; 5,3￠-diallyl-2,4￠-dihydroxydiphenyl
Molecular Formula: C18H18O2
Molecular Weight: 266.33
Percent Composition: C 81.17%, H 6.81%, O 12.01%
Literature References: Bioactive principle isolated from the bark of
Magnolia obovata, Thunb.,
Magnoliaceae and other
Magnolia species used in Japanese and Chinese traditional medicine. Name derived from "Honoki", the Japanese name of
M. obovata. Isomeric with magnolol,
q.v. Identification in methanolic extracts of
M. obovata bark: M. Fujita
et al., Chem. Pharm. Bull. 20, 212 (1972). Isoln from seeds of
M. grandiflora L.: F. S. El-Feraly, W.-S. Li,
Lloydia 41, 442 (1978). Synthesis: T. Takeya
et al., Chem. Pharm. Bull. 34, 2066 (1986). CNS depressant effects
in vivo: K. Watanabe
et al., Planta Med. 49, 103 (1983). HPLC determn in
M. officinalis extracts: T.-H. Tsai, C.-F. Chen,
J. Chromatogr. 598, 143 (1992).
Properties: Colorless needles, mp 86-86.5° (El-Feraly, Li); also reported as mp 87.5° (Fujita). Sol in usual organic solvents and caustic alkali. uv max (ethanol): 294 nm (e 8200).
Melting point: mp 86-86.5° (El-Feraly, Li); mp 87.5° (Fujita)
Absorption maximum: uv max (ethanol): 294 nm (e 8200)
