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CAS No 516-54-1 , Pregnan-20-one,3-hydroxy-, (3a,5a)-

  • Name: Pregnan-20-one,3-hydroxy-, (3a,5a)-
  • Synonyms: 3a,5a-Tetrahydroprogesterone;Pregnan-20-one,3-hydroxy-, (3a,5a)-; 3a,5a-THP; 5a-Pregnane-3a-ol-20-one; 3a,5a-Pregnanolone; Allopregnan-3a-ol-20-one; Allopregnanolone;5a-Pregnan-20-one, 3a-hydroxy- (6CI,8CI);Allotetrahydroprogesterone; (3a,5a)-3-Hydroxypregnan-20-one; (3a)-Allopregnanolone; 3a-Hydroxy-5a-dihydroprogesterone; 3a-Hydroxy-5a-pregnane-20-one; 3a-Hydroxy-5a-pregnan-20-one; (+)-3a-Hydroxy-5a-pregnan-20-one;
  • CAS Registry Number:
  • Flash Point: 183.9°C
  • Boiling Point: 431.2°Cat760mmHg
  • Density: 1.053g/cm3
  • Refractive index: 1.524
  • Water Solubility: chloroform: 20 mg/mL, clear, colorless
  • Safety Statements: 22-24/25
  • Flash Point: 183.9°C
  • Molecular Weight: 318.49
  • InChI: InChI=1/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16-,17+,18-,19-,20-,21+/m0/s1
  • Molecular Formula: C21H34 O2
  • Molecular Structure:CAS No:516-54-1 Pregnan-20-one,3-hydroxy-, (3a,5a)-

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516-54-1 ALLOPREGNANOLONE

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516-54-1 5alpha-Pregnan-3alpha-ol-20-one

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516-54-1 5alpha-Pregnan-3alpha-ol-20-one

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References of Pregnan-20-one,3-hydroxy-, (3a,5a)-
Title: Allopregnan-3a-ol-20-one
CAS Registry Number: 516-54-1
CAS Name: 3a-Hydroxy-5a-pregnan-20-one
Synonyms: 5a-pregnan-3a-ol-20-one; epiallopregnanolone; allotetrahydroprogesterone
Molecular Formula: C21H34O2
Molecular Weight: 318.49
Percent Composition: C 79.19%, H 10.76%, O 10.05%
Literature References: Naturally occurring metabolite of progesterone. Prototype of the neuroactive steroids known as epalons that allosterically modulate g-aminobutyric acid type A (GABAA) receptors in the CNS. Isoln from human pregnancy urine: R. E. Marker et al., J. Am. Chem. Soc. 59, 616 (1937). Prepn from pregnenolone: G. Fleischer et al., ibid. 60, 79 (1938). Chromatographic determn in urine: F. J. Bègue et al., J. Chromatogr. Sci. 12, 763 (1974). Synthesis, metabolism and pharmacology: R. H. Purdy et al., J. Med. Chem. 33, 1572 (1990). Review of pharmacology and therapeutic potential of epalons: K. W. Gee et al., Crit. Rev. Neurobiol. 9, 207-227 (1995).
Properties: Crystals from abs alc, mp 176-178°. [a]D +87.7° (abs alc).
Melting point: mp 176-178°
Optical Rotation: [a]D +87.7° (abs alc)
 
Derivative Type: Acetate
Molecular Formula: C23H36O3
Molecular Weight: 360.53
Percent Composition: C 76.62%, H 10.06%, O 13.31%
Properties: Crystals from aq ethanol, mp 141-142°. [a]D22 +94.5° (abs ethanol).
Melting point: mp 141-142°
Optical Rotation: [a]D22 +94.5° (abs ethanol)