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CAS No 514-65-8 , 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol

  • Name: 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol
  • Synonyms: Biperidenum; Biperidene; Biperideno [INN-Spanish]; Biperidene [INN-French]; Beperiden; Biperidenum [INN-Latin]; Biperidine;1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol;Akineton;
  • CAS Registry Number:
  • Melting Point: 114 ºC
  • Flash Point: 224.5°C
  • Boiling Point: 462.1°Cat760mmHg
  • Density: 1.105g/cm3
  • Refractive index: 1.595
  • Water Solubility: 25.1 MG/L
  • Safety Statements: Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition, it emits toxic fumes of NOx.
  • Flash Point: 224.5°C
  • EINECS: 208-184-6
  • Molecular Weight: 311.46106
  • InchiKey: YSXKPIUOCJLQIE-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,
    11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,
    23H,2,5-6,11-16H2
  • Molecular Formula: C21H29NO
  • Molecular Structure:CAS No:514-65-8 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol

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  • IUPAC NAME-(1RS,2SR,4RS)-1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin- 1-yl)propan-1-ol MOLECULAR FORMULA-C21H29NO MOLAR MASS-311.461 g/mol Biperiden is used for the adjunctive treatment of all forms of Parkinson's disease and for reduced s...
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514-65-8 Biperiden

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514-65-8 Bipariden

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514-65-8 Biperiden HCL, Lactate

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References of 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol
Title: Biperiden
CAS Registry Number: 514-65-8
CAS Name: a-Bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl-1-piperidinepropanol
Synonyms: a-5-norbornen-2-yl-a-phenyl-1-piperidinepropanol; 3-piperidino-1-phenyl-1-bicycloheptenyl-1-propanol; 1-bicycloheptenyl-1-phenyl-3-piperidinopropanol; 3-piperidino-1-phenyl-(D5-bicyclo[2.2.1]hepten-2-yl)-1-propanol
Manufacturers' Codes: KL-373
Molecular Formula: C21H29NO
Molecular Weight: 311.46
Percent Composition: C 80.98%, H 9.38%, N 4.50%, O 5.14%
Literature References: Prepn: W. Klavehn, US 2789110 (1957 to Knoll). Toxicology study: C. Hanna, Toxicol. Appl. Pharmacol. 2, 379 (1960).
Properties: Crystals, mp 101°. Difficultly sol in water; slightly sol in ethanol; readily sol in methanol. LD50 in mice (mg/kg): 195 s.c., 56 i.v. (Klavehn).
Melting point: mp 101°
Toxicity data: LD50 in mice (mg/kg): 195 s.c., 56 i.v. (Klavehn)
 
Derivative Type: Hydrochloride
CAS Registry Number: 1235-82-1
Trademarks: Akineton (Knoll); Akinophyl (Knoll)
Molecular Formula: C21H29NO.HCl
Molecular Weight: 347.92
Percent Composition: C 72.50%, H 8.69%, N 4.03%, O 4.60%, Cl 10.19%
Properties: Fluffy white powder, mp 238°. Soly in water (mg/100 ml) at 30°: 220 (pH 3.8), 280 (pH 5.5), 290 (pH 6.7), 264 (pH 7.9), 244 (9.2-10.1). LD50 in rats, dogs (mg/kg): 750, 340 orally (Hanna).
Melting point: mp 238°
Toxicity data: LD50 in rats, dogs (mg/kg): 750, 340 orally (Hanna)
 
Therap-Cat: Antiparkinsonian.
Keywords: Antiparkinsonian; Antimuscarinic.