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CAS No 51012-32-9 , N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide

  • Name: N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide
  • Synonyms: FLO 1347;tiapride; Tiapridum [INN-Latin]; Tiapridal; SBB058186; EINECS 256-907-9; 51012-32-9; Thiapride; Tiaprida [INN-Spanish];N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide;
  • CAS Registry Number:
  • Melting Point: 120
  • Density: 1.15 g/cm3
  • EINECS: 256-907-9
  • Molecular Weight: 328.42706
  • InchiKey: JTVPZMFULRWINT-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H24N2O4S/c1-5-17(6-2)10-9-16-15(18)13-11-12(22(4,
    19)20)7-8-14(13)21-3/h7-8,11H,5-6,9-10H2,1-4H3,(H,16,18)
  • Molecular Formula: C15H24N2O4S
  • Molecular Structure:CAS No:51012-32-9 N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide

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References of N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide
Title: Tiapride
CAS Registry Number: 51012-32-9
CAS Name: N-[2-(Diethylamino)ethyl]-2-methoxy-5-(methylsulfonyl)benzamide
Synonyms: N-[2-(diethylamino)ethyl]-5-(methylsulfonyl)-o-anisamide; thiapride
Manufacturers' Codes: FLC-1374
Molecular Formula: C15H24N2O4S
Molecular Weight: 328.43
Percent Composition: C 54.86%, H 7.37%, N 8.53%, O 19.49%, S 9.76%
Literature References: Dopamine receptor antagonist structurally related to sulpiride, q.v. Prepn: G. Bulteau et al., DE 2327192; GB 1394563 (1973, 1975 both to Soc. d'Etudes Sci. Ind. de L'Ile-de-France). Crystal structure: C. Houttemane et al., Acta Crystallogr. C39, 585 (1983). Dopamine receptor binding studies: T. Arima et al., Jpn. J. Pharmacol. 41, 419 (1986). Pharmacokinetics: E. Rey et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 20, 62 (1982). Clinical evaluation in neuroleptic-induced dyskinesia: W. Greil et al., Neuropsychobiology 14, 17 (1985); in alcohol withdrawal syndrome: R. Agricola et al., J. Int. Med. Res. 10, 160 (1982); G. K. Shaw et al., Br. J. Psychiatry 150, 164 (1987).
Properties: Crystals, mp 123-125°.
Melting point: mp 123-125°
 
Derivative Type: Hydrochloride
CAS Registry Number: 51012-33-0
Trademarks: Gramalil (Fujisawa); Italprid (Teofarma); Luxoben (Chinoin); Sereprile (Synthelabo); Tiapridal (Delagrange); Tiapridex (Schuerholz)
Molecular Formula: C15H24N2O4S.HCl
Molecular Weight: 364.89
Percent Composition: C 49.37%, H 6.91%, N 7.68%, O 17.54%, S 8.79%, Cl 9.72%
 
Therap-Cat: Antidyskinetic.
Keywords: Antidyskinetic.