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CAS No 51-15-0 , 2-Pyridinealdoxime methochloride

  • Name: 2-Pyridinealdoxime methochloride
  • Synonyms: 2-Pyridinealdoxime methochloride; Pralidoxime chloride; N-Methylpyridinium-2-carboxaldoxime chloride~2-PAM chloride~Pralidoxime chloride~Pyridine-2-aldoxime methochloride; Pyridine-2-carbaldoxime methochloride;2-PAM chloride; Pyridine-2-carboxaldoxime methochloride; 2-PAM chloride;2-hydroxyiminomethyl-1-methylpyridinium chloride;
  • CAS Registry Number:
  • Melting Point: 215-225 ºC
  • Flash Point: 68.5 °C
  • Boiling Point: 189.7 °C at760mmHg
  • Water Solubility: 65.5 G/100 ML (25 ºC)
  • Safety Statements: R20/22;R36/37/38
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 68.5 °C
  • EINECS: 200-080-9
  • Molecular Weight: 172.61
  • InChI: InChI=1/C7H8N2O.ClH/c1-9-5-3-2-4-7(9)6-8-10;/h2-6H,1H3;1H
  • Risk Statements: S26;S37/39
  • Molecular Formula: C7H9ClN2O
  • Molecular Structure:CAS No:51-15-0 2-Pyridinealdoxime methochloride
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51-15-0 Pyraloxime Methylchloride

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51-15-0 2-PYRIDINEALDOXIME METHOCHLORIDE; 97%

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51-15-0 Pralidoxime Chloride

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51-15-0 PRALIDOXIME CHLORIDE

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51-15-0 PRALIDOXIME CHLORIDE

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51-15-0 PRALIDOXIME CHLORIDE

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51-15-0 Pralidoxime chloride

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51-15-0 2-Pyridinealdoxime methochloride

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51-15-0 2-Pyridinealdoxime methochloride

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References of 2-Pyridinealdoxime methochloride
Title: Pralidoxime Chloride
CAS Registry Number: 51-15-0
CAS Name: 2-[(Hydroxyimino)methyl]-1-methylpyridinium chloride
Synonyms: 2-formyl-1-methylpyridinium chloride oxime; 1-methyl-2-formylpyridinium chloride oxime; N-methylpyridinium-2-aldoxime chloride; 2-pyridine aldoxime methyl chloride; 2-PAM chloride
Trademarks: Protopam (Wyeth-Ayerst)
Molecular Formula: C7H9ClN2O
Molecular Weight: 172.61
Percent Composition: C 48.71%, H 5.26%, Cl 20.54%, N 16.23%, O 9.27%
Literature References: Cholinesterase reactivator. Prepn of salts: I. B. Wilson et al., US 2816113 (1957 to U.S. Sec'y. of Army); A. A. Kondritzer et al., J. Pharm. Sci. 50, 109 (1961). Manufacturing processes: R. I. Ellin et al., US 3140289 (1964 to U.S. Dept. of the Army); McDowell, US 3155674 (1964 to Olin Mathieson). Commercial prepn: R. I. Ellin, Ind. Eng. Chem. Prod. Res. Dev. 3 (1), 20 (1964). HPLC determn in serum: P. Houzé et al., J. Chromatogr. B 814, 149 (2005). Toxicology: Christensen, Richter, Arch. Environ. Health 15, 599 (1967). Toxicity data: Fleisher et al., Toxicol. Appl. Pharmacol. 16, 40 (1970); R. I. Ellin, J. H. Wills, J. Pharm. Sci. 53, 1143 (1964). Comprehensive description: U. V. Banakar, U. N. Patel, Anal. Profiles Drug Subs. 17, 533-569 (1988).
Properties: Crystals from alcohol + ether, mp 235-238° (dec). Soly (g/100 ml) 25°: acetone 0, isopropanol 0.09, ethanol 0.89, methanol 8.5, water 65.5. LD50 in rats (mg/kg): 96 i.v. (Fleisher). LD50 in rabbits (mg/kg): 95 i.v.; LD50 in mice (mg/kg): 115 i.v., 205 i.p., 4100 orally (Ellin, Wills).
Melting point: mp 235-238° (dec)
Toxicity data: LD50 in rats (mg/kg): 96 i.v. (Fleisher); LD50 in rabbits (mg/kg): 95 i.v.; LD50 in mice (mg/kg): 115 i.v., 205 i.p., 4100 orally (Ellin, Wills)
 
Derivative Type: Pralidoxime iodide
CAS Registry Number: 94-63-3
Synonyms: 2-Pyridine aldoxime methiodide; 2-PAM
Molecular Formula: C7H9IN2O
Molecular Weight: 264.06
Percent Composition: C 31.84%, H 3.44%, I 48.06%, N 10.61%, O 6.06%
Properties: Yellow crystals from alcohol, mp 225-226°. Soly at 25°: 48 mg/ml. Very sol in water, fairly sol in hot alcohol, poorly sol in cold alcohol. Insol in ether, acetone. LD50 in mice (mg/kg): 140-178 i.v., 136-260 i.p., 290-340 s.c., 1500-4000 orally (Ellin, Wills).
Melting point: mp 225-226°
Toxicity data: LD50 in mice (mg/kg): 140-178 i.v., 136-260 i.p., 290-340 s.c., 1500-4000 orally (Ellin, Wills)
 
Derivative Type: Pralidoxime mesylate
CAS Registry Number: 154-97-2
Trademarks: Contrathion (RPR)
Molecular Formula: C8H12N2O4S
Molecular Weight: 232.26
Percent Composition: C 41.37%, H 5.21%, N 12.06%, O 27.55%, S 13.81%
Properties: Very hygroscopic crystals from ethanol, mp 155°. pKa 8.0. Soly in water: 1 g in 2 ml. LD50 in mice (mg/kg): 118-122 i.v., 216 i.p., 3700 orally; in rats (mg/kg): 109 i.v., 262 i.p. (Ellis, Wills).
Melting point: mp 155°
pKa: pKa 8.0
Toxicity data: LD50 in mice (mg/kg): 118-122 i.v., 216 i.p., 3700 orally; in rats (mg/kg): 109 i.v., 262 i.p. (Ellis, Wills)
 
Therap-Cat: Antidote (nerve gases and organophosphate insecticide poisoning.)
Keywords: Cholinesterase Reactivator; Antidote (Organophosphate Poisoning).