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CAS No 50935-04-1 , Carminomicin I

  • Name: Carminomicin I
  • Synonyms: Carminomicin I;(8S-cis)-Acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-5,12-naphthacenedione;
  • CAS Registry Number:
  • Flash Point: 407.7°C
  • Boiling Point: 750.6°Cat760mmHg
  • Density: 1.63g/cm3
  • Refractive index: 1.726
  • Safety Statements: Deadly poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 407.7°C
  • Molecular Weight: 513.49
  • InChI: InChI=1/C26H27NO10/c1-9-21(30)13(27)6-16(36-9)37-15-8-26(35,10(2)28)7-12-18(15)25(34)20-19(23(12)32)22(31)11-4-3-5-14(29)17(11)24(20)33/h3-5,9,13,15-16,21,29-30,32,34-35H,6-8,27H2,1-2H3/t9-,13-,15-,16-,21+,26-/m0/s1
  • Molecular Formula: C26H27NO10
  • Molecular Structure:CAS No:50935-04-1 Carminomicin I

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1/1
References of Carminomicin I
Title: Carubicin
CAS Registry Number: 50935-04-1
CAS Name: (8S-cis)-Acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-5,12-naphthacenedione
Synonyms: (1S,3S)-3-acetyl-1,2,3,4,6,11-hexahydro-3,5,10,12-tetrahydroxy-6,11-dioxo-1-naphthacenyl 3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranoside; 4-O-demethyldaunorubicin; carminomycin; carminomycin I; karminomycin
Molecular Formula: C26H27NO10
Molecular Weight: 513.49
Percent Composition: C 60.81%, H 5.30%, N 2.73%, O 31.16%
Literature References: Anthracycline antitumor antibiotic, related to daunorubicin and doxorubicin, q.q.v. Isoln from Actinomadura carminata: G. F. Gauze et al., Antibiotiki 18, 675 (1973); M. G. Brazhnikova et al., ibid. 678. Antitumor activity: V. A. Shorin et al., ibid. 681. Physico-chemical characteristics, structure: M. G. Brazhnikova et al., J. Antibiot. 27, 254 (1974). Pharmacokinetics, pharmacodynamics, toxicity study: L. E. Goldberg et al., Antibiotiki 19, 57 (1974). Production: M. G. Brazhnikova et al., SU 508076 (1976 to Inst. Antibiot. Res., USSR), C.A. 86, 15215 (1977). Stereochemistry: eidem, J. Antibiot. 29, 469 (1976). Synthesis from daunomycinone: G. Cassinelli et al., ibid. 31, 178 (1978). Molecular pharmacology: V. H. DuVernay et al., Cancer Res. 40, 387 (1980). Analysis in human serum: S. E. Fandrich, K. A. Pittman, J. Chromatogr. 223, 155 (1981). Early clinical studies: L.H. Baker et al., Cancer Treat. Rep. 63, 899 (1979). Embryotoxicity and teratogenicity study: I. Damjanov, A. Celluzzi, Res. Commun. Chem. Pathol. Pharmacol. 28, 497 (1980).
 
Derivative Type: Hydrochloride
CAS Registry Number: 52794-97-5
Manufacturers' Codes: NSC-180024
Molecular Formula: C26H27NO10.HCl
Molecular Weight: 549.95
Percent Composition: C 56.78%, H 5.13%, N 2.55%, O 29.09%, Cl 6.45%
Properties: Crystals from ethanol/benzene. [a]D20 +289°. uv max (ethanol): 236, 255, 462, 478, 492 (E1%1cm 300), 510, 525 nm. pKa1 8.00; pKa2 10.16. Sol in water, methanol. Practically insol in other organic solvents. LD50 in mice (mg/kg): 7.3 orally; 1.3 i.v.; 3.7 s.c. (Goldberg).
pKa: pKa1 8.00; pKa2 10.16
Optical Rotation: [a]D20 +289°
Absorption maximum: uv max (ethanol): 236, 255, 462, 478, 492 (E1%1cm 300), 510, 525 nm
Toxicity data: LD50 in mice (mg/kg): 7.3 orally; 1.3 i.v.; 3.7 s.c. (Goldberg)
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antibiotics and Analogs; Anthracyclines.