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CAS No 50847-11-5 , 2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one

  • Name: 2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one
  • Synonyms: Ketas (TN); KC-404; Ke Tas; Tocris-1694; 50847-11-5;Ketas; Ibudilastum [Latin]; Eyevinal; Ibudilastum;2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one;
  • CAS Registry Number:
  • Melting Point: 53-54 ºC
  • Density: 1.09
  • Refractive index: 1.57
  • Water Solubility: DMSO: 28 mg/mL, soluble
  • Safety Statements: R22;R36/37/38
  • Hazard Symbols: Xn: Harmful;
  • Molecular Weight: 230.30552
  • InchiKey: ZJVFLBOZORBYFE-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-
    10H,1-4H3
  • Risk Statements: S26;S36
  • Molecular Formula: C14H18N2O
  • Molecular Structure:CAS No:50847-11-5 2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one
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50847-11-5 Ibudilast

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50847-11-5 Ibudilast

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
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  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi ,ShanXiChina
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50847-11-5 lbudilast

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  • China PMIDA AGROCHEMICAL CO.,LTD [Manufacturer]
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  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone401121 ChongqingCHINA Chongqing,China
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50847-11-5 Lbudilast

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  • China Shanghai Rainbow Chemistry Co., Ltd. [Manufacturer]
  • Tel: +86-21-64968086
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  • Address: Room 128, Building B, No. 8 Lane 1305, Huajing Road, Xuhui District, Shanghai, P.R. China 200000 Shanghai CHINA Shanghai,China
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50847-11-5 Ibudilast

  • Ibudilast, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
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  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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50847-11-5 Ibudilast

  • China ORCHID CHEMICAL SUPPLIES LTD (OCS) [Importer/Exporter]
  • Tel: +86-571-85395792
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  • Address: 607, North Zhongshan Road, Hangzhou 310000 China ,ZhejiangChina
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50847-11-5 Ibudilast

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  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
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  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,China
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50847-11-5 Ibudilast

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  • Switzerland BIOTREND Chemicals AG [Manufacturer]
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  • Address: BIOTREND Chemicals AG
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50847-11-5 Ibudilast

  • United States Waterstone Technology LLC [Manufacturer]
  • Tel: 317-644-0862/ 317-218-7464
  • Fax: 317-569-8068
  • Address: Waterstone Technology LLC
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    Carmel, IN. 46032 ,United States
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References of 2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one
Title: Ibudilast
CAS Registry Number: 50847-11-5
CAS Name: 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone
Synonyms: 3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine
Manufacturers' Codes: KC-404
Trademarks: Ketas (Kyorin)
Molecular Formula: C14H18N2O
Molecular Weight: 230.31
Percent Composition: C 73.01%, H 7.88%, N 12.16%, O 6.95%
Literature References: Leukotriene D4 antagonist. Prepn: T. Irikura et al., DE 2315801; eidem, US 3850941 (1973, 1974 both to Kyorin). Pharmacology and antiallergic activity: K. Nishino et al., Jpn. J. Pharmacol. 33, 267 (1983); H. Nagai et al., ibid. 1215. In vitro cerebral vasodilating activity: M. Ohashi et al., Arch. Int. Pharmacodyn. 280, 216 (1986); in vivo activity: W. M. Armstead et al., J. Pharmacol. Exp. Ther. 244, 138 (1988). Bronchodilating activity in animals: S. Mue et al., Arch. Int. Pharmacodyn. 283, 153 (1986). Antiplatelet activity in animals: M. Ohashi et al., ibid. 321; M. Ohashi et al., Gen. Pharmacol. 17, 385 (1986).
Properties: Crystals from hexane, mp 53.5-54°. Slightly sol in water, freely sol in organic solvents. LD50 i.v. in mice: 260 mg/kg (Irikura, 1973).
Melting point: mp 53.5-54°
Toxicity data: LD50 i.v. in mice: 260 mg/kg (Irikura, 1973)
Therap-Cat: Antiallergic; antiasthmatic; vasodilator (cerebral).
Keywords: Antiallergic; Antiasthmatic (Nonbronchodilator); Leukotriene Antagonist; Vasodilator (Cerebral).