Home > Name List By c > Card-20(22)-enolide,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-,(3b,5b)- China

CAS No 508-75-8 , Card-20(22)-enolide,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-,(3b,5b)- Search by region : China

  • Name: Card-20(22)-enolide,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-,(3b,5b)-
  • Synonyms: Convallotoxin;Convallatoxin(6CI,7CI,8CI); NSC 407808; Corglykon;Strophanthidin a-L-rhamnoside; Korglykon;Card-20(22)-enolide,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-,(3b,5b)-; Corglycon; Convallatoxine; Convallatoxoside; Corglycone; Convallaotoxin; Convallaton;
  • CAS Registry Number:
  • Transport: 3249
  • Melting Point: 235-242 DEG C
  • Density: 1.41 g/cm3
  • Refractive index: 1.622
  • Safety Statements: Poison by subcutaneous, intravenous, intraduodenal, intraperitoneal, and possibly other routes. When heated to decomposition it emits acrid smoke and fumes.
  • EINECS: 208-086-3
  • Molecular Weight: 550.71
  • InChI: InChI=1/C29H42O10/c1-15-22(32)23(33)24(34)25(38-15)39-17-3-8-27(14-30)19-4-7-26(2)18(16-11-21(31)37-13-16)6-10-29(26,36)20(19)5-9-28(27,35)12-17/h11,14-15,17-20,22-25,32-36H,3-10,12-13H2,1-2H3/t15-,17-,18+,19?,20?,22-,23+,24+,25-,26+,27-,28-,29-/m0/s1
  • Molecular Formula: C29H42 O10
  • Molecular Structure:CAS No:508-75-8 Card-20(22)-enolide,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-,(3b,5b)-

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References of Card-20(22)-enolide,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-,(3b,5b)-
Title: Convallatoxin
CAS Registry Number: 508-75-8
CAS Name: (3b,5b)-3-[(6-Deoxy-a-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
Synonyms: strophanthidin a-L-rhamnoside
Trademarks: Convallaton; Corglykon; Korglykon
Molecular Formula: C29H42O10
Molecular Weight: 550.64
Percent Composition: C 63.26%, H 7.69%, O 29.06%
Literature References: From blossoms of lily of the valley (Convallaria majalis L., Liliaceae): Karrer, Helv. Chim. Acta 12, 506 (1929); from Ornithogalum umbellatum L., Liliaceae: Mrozik et al., ibid. 42, 683 (1959); from Antiaris toxicaria Lesch, Moraceae: Juslen et al., ibid. 46, 117 (1963). Structure: Tschesche, Haupt, Ber. 69, 459 (1936); Fieser, Jacobsen, J. Am. Chem. Soc. 59, 2335 (1937). Cleavage into L-rhamnose and strophanthidin: Reichstein, Katz, Pharm. Acta Helv. 18, 521 (1943); see also C.A. 38, 2046. Synthesis from strophanthidin and acetobromrhamnose: Reyle et al., Helv. Chim. Acta 33, 1541 (1950); Haede et al., DE 1933090 (1971 to Hoechst). Toxicity study: W. F?rster et al., Arch. Int. Pharmacodyn. 155, 165 (1965).
Properties: Prisms from methanol + ether. mp 235-242°. [a]D22 -1.7 ± 3° (c = 0.65 in methanol); [a]D25 -9.4 ± 3° (c = 0.72 in dioxane). Sol in alcohol, acetone; slightly sol in chloroform, ethyl acetate, and water (1:2000). Practically insol in ether, petr ether. Gives Legal's reaction. LD50 in mice, rats (mg/kg): 10.0 i.p., 16.0 i.v. (F?rster).
Melting point: mp 235-242°
Optical Rotation: [a]D22 -1.7 ± 3° (c = 0.65 in methanol); [a]D25 -9.4 ± 3° (c = 0.72 in dioxane)
Toxicity data: LD50 in mice, rats (mg/kg): 10.0 i.p., 16.0 i.v. (F?rster)
 
Derivative Type: Tri-O-acetyl-convallatoxin
Molecular Formula: C35H48O13
Molecular Weight: 676.75
Percent Composition: C 62.12%, H 7.15%, O 30.73%
Properties: Needles from acetone + ether, mp 215-238°. [a]D25 -5.5 ± 2° (c = 0.962 in chloroform).
Melting point: mp 215-238°
Optical Rotation: [a]D25 -5.5 ± 2° (c = 0.962 in chloroform)
 
Therap-Cat: Cardiotonic.
Keywords: Cardiotonic.