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CAS No 50679-08-8 , 1-(4-tert-butylphenyl)-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]
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  • Name: 1-(4-tert-butylphenyl)-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]
    butan-1-ol
  • Synonyms: 1-(4-tert-butylphenyl)-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]
    butan-1-ol; Allerplus; Teldane; Ternadin; Cyater; Teldanex;Seldane; Triludan; Terdin; Aldaban;
  • CAS Registry Number:
  • Melting Point: 145-152 ºC
  • Density: 1.088 g/cm3
  • Water Solubility: 0.001 G/100 ML (30 ºC)
  • Safety Statements: Moderately toxic by intraperitoneal route. Human systemic effects: allergic reactions, allergic rhinitis, dermatitis, serum sickness, urticaria. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. Used as an antihistamine.
  • EINECS: 256-710-8
  • Molecular Weight: 471.67344
  • InchiKey: GUGOEEXESWIERI-UHFFFAOYSA-N
  • InChI: InChI=1S/C32H41NO2/c1-31(2,
    3)26-18-16-25(17-19-26)30(34)15-10-22-33-23-20-29(21-24-33)32(35,
    27-11-6-4-7-12-27)28-13-8-5-9-14-28/h4-9,11-14,16-19,29-30,34-35H,10,15,
    20-24H2,1-3H3
  • Risk Statements: S24/25
  • Molecular Formula: C32H41NO2
  • Molecular Structure:CAS No:50679-08-8 1-(4-tert-butylphenyl)-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]<br />butan-1-ol

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References of 1-(4-tert-butylphenyl)-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]
butan-1-ol
Title: Terfenadine
CAS Registry Number: 50679-08-8
CAS Name: a-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol
Synonyms: 1-(p-tert-butylphenyl)-4-[4￠-(a-hydroxydiphenylmethyl)-1￠-piperidyl]butanol; a-(p-tert-butylphenyl)-4-(a-hydroxy-a-phenylbenzyl)-1-piperidinebutanol
Manufacturers' Codes: MDL-9918
Trademarks: Allerplus (AstraZeneca); Cyater (Lederle); Seldane (Aventis); Teldane (Aventis); Teldanex (AstraZeneca); Terfex (Leiras); Ternadin (Cantabria); Triludan (Aventis)
Molecular Formula: C32H41NO2
Molecular Weight: 471.67
Percent Composition: C 81.49%, H 8.76%, N 2.97%, O 6.78%
Literature References: Nonsedating-type histamine H1-receptor antagonist. Prepn: A. A. Carr, C. R. Kinsolving, DE 2303306; eidem, US 3878217 (1973, 1975 both to Richardson-Merrell); A. A. Carr, D. R. Meyer, Arzneim.-Forsch. 32, 1157 (1982). Series of articles on chemistry, pharmacology, toxicology and clinical studies: ibid. 32, 1153-1218 (1982). Metabolism in human liver: M. Jurima-Romet et al., Drug Metab. Dispos. 22, 849 (1994). Comprehensive description: A. A. Badwan et al., Anal. Profiles Drug Subs. 19, 627-662 (1990). Review: H. C. Masheter, Clin. Rev. Allergy 11, 5-34 (1993).
Properties: Crystals from acetone, mp 146.5-148.5°; may exist in three polymorphic forms, mp 149-152°, 146-148°, 142-144°. Soly at 30° (g/100ml): water 0.001; ethanol 3.780; methanol 3.750; hexane 0.034; 0.1M HCl 0.012; 0.1M citric acid 0.110; 0.1M tartaric acid 0.045. uv max (methanol): 260 nm (A 660.4); (ethanol): 260 nm (A 671.4); (dichloromethane): 260 nm (A 762.2). LD50 orally in mice: >2000 mg/kg (Carr, Meyer).
Melting point: mp 146.5-148.5°; mp 149-152°, 146-148°, 142-144°
Absorption maximum: uv max (methanol): 260 nm (A 660.4); (ethanol): 260 nm (A 671.4); (dichloromethane): 260 nm (A 762.2)
Toxicity data: LD50 orally in mice: >2000 mg/kg (Carr, Meyer)
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic.