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CAS No 5051-62-7 , 2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine

  • Name: 2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine
  • Synonyms: Guanabenzum [INN-Latin];Wy 8678 base;2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine; Guanabenz(USAN); Guanabenz acetate; Wytensin; Guanabenz [USAN:INN]; Guanabenzo [INN-Spanish];
  • CAS Registry Number:
  • Transport: 3249
  • Melting Point: 227-229 deg C (decomposition)
  • Flash Point: 199.1°C
  • Boiling Point: 405.7°Cat760mmHg
  • Density: 1.49g/cm3
  • Refractive index: 1.645
  • Safety Statements: 22-36/37/39
  • Hazard Symbols: Xn
  • Flash Point: 199.1°C
  • EINECS: 225-750-8
  • Molecular Weight: 231.08192
  • InchiKey: WDZVGELJXXEGPV-YIXHJXPBSA-N
  • InChI: InChI=1S/C8H8Cl2N4/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12/h1-4H,(H4,11,12,
    14)/b13-4+
  • Risk Statements: 20/21/22-62
  • Molecular Formula: C8H8Cl2N4
  • Molecular Structure:CAS No:5051-62-7 2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine

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References of 2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine
Title: Guanabenz
CAS Registry Number: 5051-62-7
CAS Name: 2-[(2,6-Dichlorophenyl)methylene]hydrazinecarboximidamide
Synonyms: [(2,6-dichlorobenzylidene)amino]guanidine; N-(2,6-dichlorobenzylidene)-N￠-amidinohydrazine
Manufacturers' Codes: NSC-68982
Molecular Formula: C8H8Cl2N4
Molecular Weight: 231.08
Percent Composition: C 41.58%, H 3.49%, Cl 30.68%, N 24.25%
Literature References: a2-Adrenergic agonist. Prepn: J. Yates, E. Haddock, GB 1019120 (1966 to Shell), C.A. 64, 11132h (1966). Use as antihypertensive: W. J. Houlihan et al., DE 1804634 (1969 to Sandoz), C.A. 71, 89976j (1969). Pharmacology: T. Baum et al., J. Pharmacol. Exp. Ther. 171, 276 (1970); E. Lampa et al., Experientia 36, 228 (1980). Disposition of 14C-guanabenz in humans: R. H. Meacham et al., Clin. Pharmacol. Ther. 27, 44 (1980). Mechanism of action: G. F. DiBona, J. Cardiovasc. Pharmacol. 6, Suppl. 3, S543 (1984). Radioimmunoassay determn in plasma: H. Tatsumi, Arzneim.-Forsch. 34, 1704 (1984). Clinical studies: A. Reppelli et al., Boll. Soc. Ital. Cardiol. 23, 177 (1978); C. V. Ram et al., J. Clin. Pharmacol. 19, 148 (1979). Clinical studies in opiate withdrawal: F. S. Tennant, R. A. Rawson, NIDA Res. Monogr. Ser. 49, 338 (1984); J. T. Murphy, Drug Intell. Clin. Pharm. 19, 32 (1985). Review of pharmacodynamic properties and therapeutic efficacy: B. Holmes et al., Drugs 26, 212-229 (1983). Comprehensive description: C. M. Shearer, Anal. Profiles Drug Subs. 15, 319-336 (1986).
Properties: White solid from acetonitrile, mp 227-229° (dec).
Melting point: mp 227-229° (dec)
 
Derivative Type: Monoacetate
CAS Registry Number: 23256-50-0
Manufacturers' Codes: Wy-8678
Trademarks: Rexitene (LPD); Tenelid (Helsinn); Wytensin (Wyeth)
Molecular Formula: C10H12Cl2N4O2
Molecular Weight: 291.13
Percent Composition: C 41.26%, H 4.15%, Cl 24.36%, N 19.24%, O 10.99%
Properties: Solid, mp 192.5° (dec). Soly at 25° (mg/ml): water 11; alcohol 50; propylene glycol 100; chloroform 0.6; ethyl acetate 1.
Melting point: mp 192.5° (dec)
 
Therap-Cat: Antihypertensive.
Keywords: a-Adrenergic Agonist; Antihypertensive; Guanidine Derivatives.