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CAS No 503-49-1 , 3-hydroxy-3-methylpentanedioic acid

  • Name: 3-hydroxy-3-methylpentanedioic acid
  • Synonyms: Dicrotalic acid;3-hydroxy-3-methylpentanedioic acid;3-Hydroxy-3-methylglutaric acid; HMGA; 3-Hydroxy-3-methylpentanedioic acid; Lipoglutaren;
  • CAS Registry Number:
  • Density: 1.417 g/cm3
  • Refractive index: 1.512
  • Safety Statements: Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. Used as an antihyperlipoproteinemic agent. When heated to decomposition it emits acrid smoke and fumes.
  • Hazard Symbols: Xi
  • EINECS: 207-971-1
  • Molecular Weight: 162.1406
  • InchiKey: NPOAOTPXWNWTSH-UHFFFAOYSA-N
  • InChI: InChI=1S/C6H10O5/c1-6(11,2-4(7)8)3-5(9)10/h11H,2-3H2,1H3,(H,7,8)(H,9,10)
  • Risk Statements: 36/37/38
  • Molecular Formula: C6H10O5
  • Molecular Structure:CAS No:503-49-1 3-hydroxy-3-methylpentanedioic acid

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503-49-1 3-HYDROXY-3-METHYLGLUTARIC ACID

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503-49-1 Meglutol

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References of 3-hydroxy-3-methylpentanedioic acid
Title: Meglutol
CAS Registry Number: 503-49-1
CAS Name: 3-Hydroxy-3-methylpentanedioic acid
Synonyms: 3-hydroxy-3-methylglutaric acid; dicrotalic acid; medroglutaric acid; HMG; HMGA
Manufacturers' Codes: CB-337
Trademarks: Lipoglutaren (Ausonia); Mevalon (Guidotti)
Molecular Formula: C6H10O5
Molecular Weight: 162.14
Percent Composition: C 44.45%, H 6.22%, O 49.34%
Literature References: Hypolipidemic agent that decreases the rate of cholesterol synthesis. Prepn via Reformatsky reaction between ethyl acetoacetate and ethyl bromoacetate: R. Adams, B. L. Van Duuren, J. Am. Chem. Soc. 75, 2377 (1953). Synthesis via oxidation of diallylmethylcarbinol with ozone and hydrogen peroxide: H. J. Klosterman, F. Smith, ibid. 76, 1229 (1954); J. L. Rabinowitz, Biochem. Prep. 6, 25 (1958). Caution: attempts to increase batch size of the ozonolysis resulted in an explosion, cf. Chem. Eng. News 51(6), 29 (1973). Improved synthesis: A. Yavrouian et al., Synthesis 1981, 791. Hypocholesteremic properties: Z. H. Beg, M. Siddiqi, Experientia 23, 380 (1967); M. Siddiqi, Z. H. Beg, US 3629449 (1971); Z. H. Beg, P. J. Lupien, Biochim. Biophys. Acta 260, 439 (1972); A. N. K. Yusufi, M. Siddiqi, Atherosclerosis 20, 517 (1974); C. D. Padova et al., Life Sci. 30, 1907 (1982). Biosynthetic studies: L. W. White, H. Rudney, Biochemistry 9, 2713 (1970); L. Hagenfeldt, K. Hellstrom, Life Sci. 9, Pt. 2, 991 (1970). Organ distribution: L. L. Savoie, P. J. Lupien, Can. J. Physiol. Pharmacol. 53, 638 (1975). Effectiveness in familial hypercholesteremia: P. J. Lupien et al., J. Clin. Pharmacol. 19, 120 (1979). GC study in patients with organic acidurias: K. Tanaka, D. J. Hine, J. Chromatogr. 239, 301 (1982). Toxicological study: L. L. Savoie, P. J. Lupien, Arzneim.-Forsch. 25, 1284 (1975).
Properties: Cryst from ether/petr ether, mp 108-109°. Sol in water. Stable when stored dry. LD50 in mice (g/kg): 7.33 orally; 3.23 i.p. (Savoie, Lupien).
Melting point: mp 108-109°
Toxicity data: LD50 in mice (g/kg): 7.33 orally; 3.23 i.p. (Savoie, Lupien)
Therap-Cat: Antilipemic.
Keywords: Antilipemic.