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CAS No 50264-69-2 , 1-[(2,4-dichlorophenyl)methyl]indazole-3-carboxylic acid

  • Name: 1-[(2,4-dichlorophenyl)methyl]indazole-3-carboxylic acid
  • Synonyms: Lonidamina; Doridamina; Lonidamin;1-[(2,4-dichlorophenyl)methyl]indazole-3-carboxylic acid; DICA; Lonidaminum; 50264-69-2; 1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid;Diclondazolic acid;
  • CAS Registry Number:
  • Melting Point: 207-209 ºC
  • Density: 1.47 g/cm3
  • Refractive index: 1.678
  • Water Solubility: soluble in methanol or acetic acid
  • Safety Statements: R60;R22;R40
  • Hazard Symbols: T: Toxic;
  • EINECS: 256-510-0
  • Molecular Weight: 321.1581
  • InchiKey: WDRYRZXSPDWGEB-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H10Cl2N2O2/c16-10-6-5-9(12(17)7-10)8-19-13-4-2-1-3-11(13)14
    (18-19)15(20)21/h1-7H,8H2,(H,20,21)
  • Risk Statements: S53;S22;S36/37/39;S45
  • Molecular Formula: C15H10Cl2N2O2
  • Molecular Structure:CAS No:50264-69-2 1-[(2,4-dichlorophenyl)methyl]indazole-3-carboxylic acid
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50264-69-2 lonidamine

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50264-69-2 lonidamine

  • China Xilin Chemical Group Co., Ltd []
  • Tel: +86-(0)-15527136576
  • Fax: +86-(27)-83820093
  • Address: 16# Luojiashan, Wuchang District, Wuhan, Hubei 430071, ,China
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50264-69-2 lonidamine

  • China YiPeng Chemical [Manufacturers]
  • Tel: 571 85376369
  • Fax: 571 88233092
  • Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China ,ZheJiangChina
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50264-69-2 lonidamine

  • Hong kong Achemo Sientific cooperation [Manufacturers]
  • Tel: 00852-39711547
  • Fax: 00852-39711547
  • Address: 38 Plaza,38 Shantung street,MongKoK,kowloon,Hongkong Kowloon,KowloonHong kong
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50264-69-2 Lonidamine

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50264-69-2 LONIDAMINE

  • India JAI RADHE SALES []
  • Fax: 0091-79-26569884
  • Address: 309/310 HARIKRUPA TOWER,NR.OLD SHARDA MANDIR CHAR RASTA,ELLISBRIDGE ,AHMEDABAD,GUJRAT , INDIA. ,India
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50264-69-2 LONIDAMINE

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50264-69-2 Lonidamine

  • India Shreeji Pharma International [Manufacturers]
  • Tel: +91-265-3019110
  • Fax: +91-265-2465036
  • Address: FF/10, Narsinghdham Complex, Sangam Chararasta, Harni Road, Vadodara, Gujarat 390018, Vadodara,GujaratIndia
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50264-69-2 1-[(2,4- DICHLOROPHENYL)METHYL]-1H-INDAZOLE-3-CARBOXYLI C ACID 98.5% FW 321.16

  • United States RIA INTERNATIONAL [Manufacturer]
  • Tel: 973-581-1282
  • Fax: 973-581-1283
  • Address: RIA INTERNATIONAL
    11 Melanie Lane 17,
    East Hanover, NJ 07936, USA ,United States
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50264-69-2 lonidamine

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References of 1-[(2,4-dichlorophenyl)methyl]indazole-3-carboxylic acid
Title: Lonidamine
CAS Registry Number: 50264-69-2
CAS Name: 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid
Synonyms: 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid; diclondazolic acid; DICA
Manufacturers' Codes: AF-1890
Trademarks: Doridamina (Angelini)
Molecular Formula: C15H10Cl2N2O2
Molecular Weight: 321.16
Percent Composition: C 56.10%, H 3.14%, Cl 22.08%, N 8.72%, O 9.96%
Literature References: Antitumor agent with antispermatogenic activity; inhibits cellular respiration in neoplastic cells. Prepn: G. Palazzo, B. Silvestrini, DE 2310031; eidem, US 3895026 (1973, 1975 both to Angelini Francesco); G. Corsi, G. Palazzo, J. Med. Chem. 19, 778 (1976). Antispermatogenic activity: T. J. Lobl, Arch. Androl. 2, 353 (1979). In vitro and in vivo antitumor activity: B. Silvestrini et al., Br. J. Cancer 47, 221 (1983). Mechanism of action in neoplastic cells: A. Floridi et al., Exp. Mol. Pathol. 42, 293 (1985). Pharmacology: V. Cioli et al., Arzneim.-Forsch. 34, 455 (1984). HPLC determn in plasma and urine: R. Leclaire et al., J. Chromatogr. 277, 427 (1983). Toxicological study: R. Heywood et al., Chemotherapy (Basel) 27, Suppl. 2, 91 (1981). Series of articles on mechanism of action, pharmacokinetics and clinical applications in spermatogenesis and tumors: ibid. 5-120; on pharmacology and clinical evaluation in cancers: Oncology 41, Suppl. 1, 1-121 (1984). Symposium on clinical evaluations in cancers: Semin. Oncol. 18, Suppl 4, 1-72 (1991).
Properties: Crystals from ethanol, mp 207°. Sol in methanol, acetic acid. LD50 in mice, rats (mg/kg): 900, 1700 orally; 435, 525 i.p. (Heywood).
Melting point: mp 207°
Toxicity data: LD50 in mice, rats (mg/kg): 900, 1700 orally; 435, 525 i.p. (Heywood)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic.