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CAS No 5011-34-7 , 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine Search by region : Germany

  • Name: 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine
  • Synonyms: 5011-34-7;1-(2,3,4-Trimethoxybenzyl)piperazine;1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; Trimetazidina [INN-Spanish]; Trimetazidinum [INN-Latin];
  • CAS Registry Number:
  • Melting Point: 200 - 205
  • Flash Point: 174 ºC
  • Boiling Point: 364 ºC at 760 mmHg
  • Density: 1.092 g/cm3
  • Hazard Symbols: Xi
  • Flash Point: 174 ºC
  • EINECS: 225-690-2
  • Molecular Weight: 266.33608
  • InchiKey: UHWVSEOVJBQKBE-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H22N2O3/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-
    16/h4-5,15H,6-10H2,1-3H3
  • Molecular Formula: C14H22N2O3
  • Molecular Structure:CAS No:5011-34-7 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine

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References of 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine
Title: Trimetazidine
CAS Registry Number: 5011-34-7
CAS Name: 1-[(2,3,4-Trimethoxyphenyl)methyl]piperazine
Molecular Formula: C14H22N2O3
Molecular Weight: 266.34
Percent Composition: C 63.13%, H 8.33%, N 10.52%, O 18.02%
Literature References: Coronary vasodilator. Prepn: Regnier, Canevari, FR 1302958 (1962 to Sci. Union et Cie, Soc. Fran?. Rech. Med.); FR M805; J. Servier, US 3262852 (1961, 1966 to Biofarma). Pharmacology: Fujita, Jpn. J. Pharmacol. 17, 19 (1967); Nagata et al., ibid. 19, 628 (1969); 21, 337 (1971). GC-MS determn in biological fluids: L. Fay et al., J. Chromatogr. 490, 198 (1989). Review of pharmacology, toxicology and clinical studies: C. Harpey et al., Cardiovasc. Drug Rev. 6, 292-312 (1989).
Properties: bp2 200-205°.
Boiling point: bp2 200-205°
 
Derivative Type: Dihydrochloride
CAS Registry Number: 13171-25-0
Trademarks: Kyurinett (Zensei); Vastarel F (Kyoto); Yoshimilon (Kowa Yakuhin)
Molecular Formula: C14H22N2O3.2HCl
Molecular Weight: 339.26
Percent Composition: C 49.56%, H 7.13%, N 8.26%, O 14.15%, Cl 20.90%
Properties: Crystals, mp 225-228°. LD50 in male, female mice, rats (mg/kg): 91, 107, 124, 124 i.v.; 264, 245, 327, 288 i.p.; 528, 608, 1147, 987 orally (Harpey).
Melting point: mp 225-228°
Toxicity data: LD50 in male, female mice, rats (mg/kg): 91, 107, 124, 124 i.v.; 264, 245, 327, 288 i.p.; 528, 608, 1147, 987 orally (Harpey)
 
Therap-Cat: Antianginal.
Keywords: Vasodilator (Coronary).