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CAS No 50-81-7 , (2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one

  • Name: (2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one
  • Synonyms: Cebione; Ascorbicap; Cecon; Cevalin; ascorbate;(2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one; vitamin C; Ascoltin; Cevex;l-ascorbic acid;
  • CAS Registry Number:
  • Melting Point: 190-192 ºC
  • Density: 1,65 g/cm3
  • Refractive index: 21 ° (C=10, H2O)
  • Alpha: 20.5 º (C=10,H2O)
  • Water Solubility: 333 G/L (20 ºC)
  • Safety Statements: S24/25
  • Hazard Symbols: Xn
  • EINECS: 200-066-2
  • Molecular Weight: 176.12412
  • InchiKey: CIWBSHSKHKDKBQ-JLAZNSOCSA-N
  • InChI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,
    5+/m0/s1
  • Risk Statements: S24/25
  • Molecular Formula: C6H8O6
  • Molecular Structure:CAS No:50-81-7 (2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one
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50-81-7 ASCORBIC ACID (VITAMIN C)

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
  • Fax: +49-9231-9619-60
  • Address: Cfm Oskar Tropitzsch
    Waldershofer Str. 49-51
    95615 Marktredwitz
    Germany null,nullGermany
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50-81-7 L(+)-Ascorbic acid

  • China YiPeng Chemical [Manufacturers]
  • Tel: 571 85376369
  • Fax: 571 88233092
  • Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China null,ZheJiangChina
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50-81-7 Calcium Ascorbate

  • Calcium Ascorbate, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,nullChina
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50-81-7 Cevitamic Acid

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50-81-7 1-Ascorbic Acid

  • China Simag Chemicals [Manufacturer]
  • Tel: +86 592 2680277
  • Fax: +86 592 2680237
  • Address: Simag Chemicals
    A-9D Atlantic sea view city,
    No.9 Hubin West Rd.,
    Xiamen China. null,nullChina
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50-81-7 Ascorbic Acid

  • China Shanghai Xunxin Chemical Co., Ltd [Manufacturers]
  • Tel: +86-(21)-38218795
  • Fax: +86-(21)-38218795
  • Address: 580 Lane, Kanghong Road, Pudong New District, Shanghai 201315, Shanghai,ShanghaiChina
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50-81-7 l-Ascorbic acid

  • Min. Order: 10
  • India Ramsun Rasayanics [Trading Company, Agent, Distributor/Wholesaler]
  • Tel: 91-97424-75780
  • Address: #73, 3rd Main, Kalyan Nagar, Nagarbhavi Main Rd Bangalore,KarnatakaIndia
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50-81-7 Ascorbic Acid

  • China Ningbo Inno Pharmchem Co., Ltd. [Manufacturers]
  • Tel: +86-(574)-87319282
  • Fax: +86-(574)-56877908
  • Address: 5F, Building 4, 1035 Guangxian Rd., Ningbo Hi-Tech Park, Ningbo, Zhejiang 315040, Ningbo,ZhejiangChina
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50-81-7 L-Ascorbic acid (Vitamin C)

  • L-Ascorbic acid (Vitamin C), 98%
  • United Kingdom Cardiff Chemicals Limited [Manufacturer]
  • Tel: +44(0) 29 20 779612
  • Fax: +44(0) 29 20 779612
  • Address: Unit 10, CF3 0EF CardiffUNITED KINGDOM CF3 0EF Cardiff,nullUnited Kingdom
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50-81-7 Ascorbic Acid

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References of (2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one
Title: Ascorbic Acid
CAS Registry Number: 50-81-7
CAS Name: L-Ascorbic acid
Synonyms: vitamin C; 3-oxo-L-gulofuranolactone; L-threo-hex-2-enonic acid g-lactone; L-3-keto-threo-hexuronic acid lactone; L-xylo-ascorbic acid; antiscorbutic vitamin; cevitamic acid
Trademarks: Ascorbicap (Valeant); Ascorbin (Montavit); Ascorvit (Jenapharm); Cantan (Aventis); Cebion (Merck KGaA); Cecon (Abbott); Celaskon (Leciva); Celin (GSK); Cetebe (GSK); Cevalin (Lilly); Ce-Vi-Sol (BMS); Cevitan (Aventis); Cewin (Sanofi-Synthelabo); C-Vimin (AstraZeneca); Hicee (Takeda); Hybrin (Pfizer); Laroscorbine (Roche); Redoxon (Roche); Ribena (GSK); Vitacimin (Takeda); Vitacin (Towa Yakuhin); Vitascorbol (Aventis)
Molecular Formula: C6H8O6
Molecular Weight: 176.12
Percent Composition: C 40.92%, H 4.58%, O 54.51%
Literature References: Physiological antioxidant. Coenzyme for a number of hydroxylation reactions; required for collagen synthesis. Widely distributed in plants and animals. Most primates (including humans), guinea pigs, and some birds and fish cannot synthesize ascorbic acid. Inadequate intake results in deficiency syndromes such as scurvy. Dietary sources include citrus fruits, potatoes, peppers, broccoli, cabbage, and rose hips. First isolated from the adrenal cortex of ox and later from lemons and paprika (originally called hexuronic acid): A. Szent-Gy?rgyi, Biochem. J. 22, 1387 (1928); W. N. Haworth, A. Szent-Gy?rgyi, Nature 131, 24 (1933). Structure studies: R. W. Herbert et al., J. Chem. Soc. 1933, 1270. Synthesis: R. G. Ault et al., ibid. 1419; T. Reichstein et al., Helv. Chim. Acta 16, 561, 1019 (1933); 17, 311, 510 (1934). Review of discovery, structure and synthesis: E. L. Hirst, Fortschr. Chem. Org. Naturst. 2, 132-159 (1939). Crystal structure: J. Hvoself, Acta Chem. Scand. 18, 841 (1964). Review of syntheses: T. C. Crawford, S. A. Crawford, Adv. Carbohydr. Chem. 37, 79-155 (1980). HPLC determn in plasma: J. Lykkesfeldt et al., Anal. Biochem. 229, 329 (1995). Discussion of use in the treatment of the common cold: L. Pauling, Proc. Natl. Acad. Sci. USA 68, 2678 (1971); H. Hemil?, Scand. J. Infect. Dis. 26, 1 (1994). Clinical applications in immunology, lipid metabolism and cancer: Int. J. Vitam. Nutr. Res. 1982, Suppl. 23, 294 pp. Comprehensive description: I. A. Al-Meshal, M. M. A. Hassan, Anal. Profiles Drug Subs. 11, 45-78 (1982). Reviews: G. M. Jaffe in Kirk-Othmer Encyclopedia of Chemical Technology vol. 24 (John Wiley & Sons, New York, 3rd Ed., 1984) pp 8-40; "Vitamin C" in Vitamins, W. Friedrich, Ed. (Walter de Gruyter, Berlin, 1988) pp 929-1001. Review of pharmacology and clinical applications: M. Levine, N. Engl. J. Med. 314, 892-902 (1986); H. E. Sauberlich, Annu. Rev. Nutr. 14, 371-391 (1994).
Properties: Crystals (usually plates, sometimes needles, monoclinic system). Pleasant, sharp acidic taste. mp 190-192° (some dec). d 1.65. [a]D25 +20.5 to +21.5° (c = 1 in water); [a]D23 +48° (c = 1 in methanol). pH = 3 (5 mg/ml); pH = 2 (50 mg/ml); pK1 = 4.17; pK2 = 11.57. uv max at pH 2: 245 nm (E1%1cm 695); at pH 6.4: 265 nm (E1%1cm 940). Redox potential (first stage): E10 +0.166 V (pH 4). One gram dissolves in about 3 ml water, 30 ml alc, 50 ml abs alc, 100 ml glycerol, 20 ml propylene glycol. Soly in water: 80.0% at 100°; 40.0% at 45°. Insol in ether, chloroform, benzene, petr ether, oils, fats, fat solvents. Strong reducing agent. Stable to air when dry; aq solns are rapidly oxidized by air.
Melting point: mp 190-192° (some dec)
pKa: pK1 = 4.17; pK2 = 11.57
Optical Rotation: [a]D25 +20.5 to +21.5° (c = 1 in water); [a]D23 +48° (c = 1 in methanol)
Absorption maximum: uv max at pH 2: 245 nm (E1%1cm 695); at pH 6.4: 265 nm (E1%1cm 940)
Density: d 1.65
 
Derivative Type: Calcium hypophosphite
Synonyms: Asphocalcium
Trademarks: Calscorbat (Aerocid)
Molecular Formula: C6H9CaO8P
Molecular Weight: 280.18
Percent Composition: C 25.72%, H 3.24%, Ca 14.30%, O 45.68%, P 11.05%
 
Derivative Type: Calcium salt
CAS Registry Number: 5743-27-1
Synonyms: Calcium ascorbate
Molecular Formula: C12H14CaO12
Molecular Weight: 390.31
Percent Composition: C 36.93%, H 3.62%, Ca 10.27%, O 49.19%
Literature References: Prepn: Ruskin, Merrill, Science 105, 504 (1947).
Properties: Dihydrate, triclinic crystals, [a]D20 +95.6° (c = 2.4). Freely sol in water. Practically insol in methanol, ethanol.
Optical Rotation: [a]D20 +95.6° (c = 2.4)
 
Derivative Type: Sodium salt
CAS Registry Number: 134-03-2
Synonyms: Sodium ascorbate
Trademarks: Cenolate (Abbott); Xitix (Woelm)
Molecular Formula: C6H7NaO6
Molecular Weight: 198.11
Percent Composition: C 36.38%, H 3.56%, Na 11.60%, O 48.46%
Literature References: Prepn: Holland, US 2442005 (1948).
Properties: Minute crystals, dec 218°. [a]D20 +104.4°. Soly in water: 62 g/100 ml at 25°; 78 g/100 ml at 75°.
Optical Rotation: [a]D20 +104.4°
 
Use: As antimicrobial and antioxidant in foodstuffs.
Therap-Cat: Vitamin (antiscorbutic).
Therap-Cat-Vet: Vitamin (antiscorbutic).
Keywords: Vitamin/Vitamin Source; Vitamin C.