Title: Niclosamide
CAS Registry Number: 50-65-7
CAS Name: 5-Chloro-
N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Synonyms: 2¢,5-dichloro-4¢-nitrosalicylanilide; 5-chloro-
N-(2¢-chloro-4¢-nitrophenyl)salicylamide; 5-chlorosalicyloyl-(
o-chloro-
p-nitranilide);
N-(2¢-chloro-4¢-nitrophenyl)-5-chlorosalicylamide
Manufacturers' Codes: Bayer 2353
Trademarks: Cestocide (Bayer); Niclocide (Miles); Ruby (Spencer); Trédémine (RPR); Yomesan (Bayer)
Molecular Formula: C13H8Cl2N2O4
Molecular Weight: 327.12
Percent Composition: C 47.73%, H 2.47%, Cl 21.68%, N 8.56%, O 19.56%
Literature References: Prepn:
GB 824345 (1959 to Bayer),
C.A. 54, 15822b (1960).
See also: E. Schraufst?tter, R. G?nnert,
US 3079297; R. Strufe
et al., US 3113067 (both 1963 to Bayer); Bekhli
et al., Med. Prom. SSSR 1965, 25.
Properties: Pale yellow crystals, mp 225-230°. Practically insol in water. Sparingly sol in ethanol, chloroform, ether.
Melting point: mp 225-230°
Derivative Type: Ethanolamine salt
CAS Registry Number: 1420-04-8
Synonyms: Clonitrilide
Trademarks: Bayluscid (Bayer)
Molecular Formula: C13H8Cl2N2O4.C2H7NO
Molecular Weight: 388.20
Percent Composition: C 46.41%, H 3.89%, Cl 18.27%, N 10.82%, O 20.61%
Properties: Yellow-brown solid, mp 204°.
Melting point: mp 204°
Use: The ethanolamine salt as a molluscicide.
Therap-Cat: Anthelmintic (Cestodes).
Therap-Cat-Vet: Anthelmintic (Cestodes).
Keywords: Anthelmintic (Cestodes).