Home > Name List By 3 > 3-(5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-ylidene)-N, N-dimethylpropan-1-amine China

CAS No 50-48-6 , 3-(5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-ylidene)-N,
N-dimethylpropan-1-amine Search by region : China

  • Name: 3-(5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-ylidene)-N,
    N-dimethylpropan-1-amine
  • Synonyms: Flavyl; Seroten; Tryptanol; Damitriptyline; Proheptadiene; Lantron; Triptanol;3-(5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-ylidene)-N,
    N-dimethylpropan-1-amine; Elavil;Damilen;
  • CAS Registry Number:
  • Melting Point: 196-197 ºC
  • Flash Point: 174°C
  • Boiling Point: 398.2°Cat760mmHg
  • Density: 1.076g/cm3
  • Water Solubility: 9.7 MG/ML
  • Safety Statements: Human poison by an unspecified route. Poison experimentally by ingestion, intraperitoneal, subcutaneous, intramuscular, and intravenous routes. Human systemic effects by ingestion and intramuscular routes: changes in sleep, headache, paresthesia, convulsions, excitement, somnolence, muscle contractions, change in heart rate, and other cardiac changes. An experimental teratogen. Other experimental reproductive effects. An antidepressant. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 174°C
  • EINECS: 200-041-6
  • Molecular Weight: 277.40332
  • InchiKey: KRMDCWKBEZIMAB-UHFFFAOYSA-N
  • InChI: InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-
    19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
  • Molecular Formula: C20H23N
  • Molecular Structure:CAS No:50-48-6 3-(5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-ylidene)-N,<br />N-dimethylpropan-1-amine

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References of 3-(5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-ylidene)-N,
N-dimethylpropan-1-amine
Title: Amitriptyline
CAS Registry Number: 50-48-6
CAS Name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
Synonyms: 10,11-dihydro-N,N-dimethyl-5H-dibenzo[a,d]cycloheptene-D5,g-propylamine; 5-(g-dimethylaminopropylidene)-5H-dibenzo[a,d]-10,11-dihydrocycloheptene; 10,11-dihydro-5-(g-dimethylaminopropylidene)-5H-dibenzo[a,d]cycloheptene; 5-(3-dimethylaminopropylidene)dibenzo[a,d][1,4]cycloheptadiene
Molecular Formula: C20H23N
Molecular Weight: 277.40
Percent Composition: C 86.59%, H 8.36%, N 5.05%
Literature References: Prepn: Hoffsommer et al., J. Org. Chem. 27, 4134 (1962); 28, 1751 (1963); J. Med. Chem. 8, 555 (1965); Engelhardt et al., BE 584061 (1960 to Merck & Co.); GB 858187; GB 858188 (both 1961 to Hoffmann-La Roche); Tristram, Tull, US 3205264 (1965 to Merck & Co.). Toxicity data: A. Tobe et al., Arzneim.-Forsch. 31, 1278 (1981). Comprehensive description: K. W. Blessel et al., Anal. Profiles Drug Subs. 3, 127-148 (1974).
 
Derivative Type: Hydrochloride
CAS Registry Number: 549-18-8
Manufacturers' Codes: Ro-4-1575
Trademarks: Adepril (Teofarma); Amineurin (Hexal); Domical (Berk); Elavil (AstraZeneca); Endep (Roche); Euplit (Desitin); Laroxyl (Roche); Lentizol (Lundbeck); Miketorin (Schering); Redomex (Lundbeck); Saroten (Bayer); Sarotex (Lundbeck); Triptizol (SIT); Tryptanol (Merck & Co.); Tryptizol (Merck & Co.)
Molecular Formula: C20H23N.HCl
Molecular Weight: 313.86
Percent Composition: C 76.54%, H 7.71%, N 4.46%, Cl 11.30%
Properties: Minute crystals, mp 196-197°. Freely sol in water, chloroform, alc. uv max (methanol): 240 nm (e 13800). pKa 9.4. LD50 in mice, rats (mg/kg): 350, 380 orally; 65, 75 i.p. (Tobe).
Melting point: mp 196-197°
pKa: pKa 9.4
Absorption maximum: uv max (methanol): 240 nm (e 13800)
Toxicity data: LD50 in mice, rats (mg/kg): 350, 380 orally; 65, 75 i.p. (Tobe)
 
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Tricyclics.