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CAS No 50-35-1 , 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

  • Name: 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
  • Synonyms: Theophilcholine; Psychotablets; Talimol; Corronarobetin; Distaval;Thalomid; Algosediv; Sedoval; Softenon;2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;
  • CAS Registry Number:
  • Transport: UN 2811
  • Melting Point: 269-271 ºC
  • Density: 1.503 g/cm3
  • Refractive index: 1.646
  • Water Solubility: <0.1 G/100 ML AT 22 ºC
  • Safety Statements: R46;R61;R21;R25;R62
  • Hazard Symbols: T: Toxic;
  • EINECS: 200-031-1
  • Molecular Weight: 258.2295
  • InchiKey: UEJJHQNACJXSKW-UHFFFAOYSA-N
  • InChI: InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13
    (15)19/h1-4,9H,5-6H2,(H,14,16,17)
  • Risk Statements: S53;S22;S26;S36/37/39;S45
  • Molecular Formula: C13H10N2O4
  • Molecular Structure:CAS No:50-35-1 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

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References of 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Title: Thalidomide
CAS Registry Number: 50-35-1
CAS Name: 2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Synonyms: N-(2,6-dioxo-3-piperidyl)phthalimide; a-phthalimidoglutarimide; 3-phthalimidoglutarimide; 2,6-dioxo-3-phthalimidopiperidine; N-phthalylglutamic acid imide; N-phthaloylglutamimide
Manufacturers' Codes: K-17
Trademarks: Contergan; Neurosedyn; Softenon; Thalomid (Celgene)
Molecular Formula: C13H10N2O4
Molecular Weight: 258.23
Percent Composition: C 60.47%, H 3.90%, N 10.85%, O 24.78%
Literature References: Selective inhibitor of tumor necrosis factor a (TNF-a). Formerly used as sedative, hypnotic. Prepn: GB 768821 (1957 to Chemie Grünenthal). Teratogenicity studies: I. D. Fratta et al., Toxicol. Appl. Pharmacol. 7, 268 (1965). Review of proposed mechanisms of embryopathy: T. D. Stephens, Teratology 38, 229-239 (1988). HPLC determn in plasma: A. Delon et al., J. Liq. Chromatogr. 18, 297 (1995). Stereospecific determn and pharmacokinetics of enantiomers: T. Eriksson et al., Chirality 7, 44 (1995). Clinical trial in HIV wasting syndrome: G. Reyes-Terán et al., AIDS 10, 1501 (1996); in aphthous ulcers related to HIV infection: J. M. Jacobson et al., N. Engl. J. Med. 336, 1487 (1997). Review of chemistry, pharmacokinetics and clinical safety: V. Günzler, Drug Saf. 7, 116-134 (1992); of effect on TNF-a and clinical use in leprosy and tuberculosis: J. D. Klausner et al., Clin. Immunol. Immunopathol. 81, 219-223 (1996); of pharmacology, history and potential clinical uses: D. Stirling et al., J. Am. Pharm. Assoc. NS37, 307-313 (1997); of use in multiple myeloma: S. V. Rajkumar, Expert Rev. Anticancer Ther.1, 20-28 (2001); of pharmacology and toxicology: C. Meierhofer, C. J. Wiedermann, Curr. Opin. Drug Disc. Devel. 6, 92-99 (2003); of clinical experience: S. J. Matthews, C. McCoy, Clin. Ther. 25, 342-395 (2003).
Properties: Needles, mp 269-271°. uv max (neutral soln): 220, 300 nm. Soly in water: ~2 ′ 10-4 mol/L; 45-60 mg/L. Sparingly sol in water, methanol, ethanol, acetone, ethyl acetate, butyl acetate, glacial acetic acid. Very sol in dioxane, DMF, pyridine. Practically insol in ether, chloroform, benzene.
Melting point: mp 269-271°
Absorption maximum: uv max (neutral soln): 220, 300 nm
Therap-Cat: Immunomodulator.
Keywords: Sedative/Hypnotic; Piperidinediones; Immunomodulator.